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__NOTOC__
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{{Gangrene}}
{{Gangrene}}
{{CMG}}; {{AE}} [[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]]


{{CMG}}
==Overview==
 
[[Amputation]] and [[death]] are the most common consequence of [[critical limb ischemia]]/ [[chronic limb-threatening ischemia]]. <ref name="pmid25439329">{{cite journal| author=Elsayed S, Clavijo LC| title=Critical limb ischemia. | journal=Cardiol Clin | year= 2015 | volume= 33 | issue= 1 | pages= 37-47 | pmid=25439329 | doi=10.1016/j.ccl.2014.09.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25439329  }} </ref> [[Gas gangrene]] has a higher [[fatality rate]], ranging from 25% to 100%, if [[treatment]] is inadequate or delayed. Increased [[age]], several [[comorbidities]] present, and involvement of [[trunk]] lead to a poor [[prognosis]]. <ref name="pmid26631369">{{cite journal| author=Yang Z, Hu J, Qu Y, Sun F, Leng X, Li H | display-authors=etal| title=Interventions for treating gas gangrene. | journal=Cochrane Database Syst Rev | year= 2015 | volume= | issue= 12 | pages= CD010577 | pmid=26631369 | doi=10.1002/14651858.CD010577.pub2 | pmc=8652263 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26631369  }} </ref>
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==Complications==
==Complications==
 
*[[Amputation]] and [[death]] are the most common consequence of [[critical limb ischemia]]/ [[chronic limb-threatening ischemia]]. <ref name="pmid25439329">{{cite journal| author=Elsayed S, Clavijo LC| title=Critical limb ischemia. | journal=Cardiol Clin | year= 2015 | volume= 33 | issue= 1 | pages= 37-47 | pmid=25439329 | doi=10.1016/j.ccl.2014.09.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25439329  }} </ref>
Complications depend on where in the body the gangrene is, how much gangrene there is, the cause of the gangrene, and the person's overall condition. Complications can include:
*[[Below-the-knee amputations]] lead to a higher ambulatory rate than [[above-the-knee amputations]].<ref name="pmid17544035">{{cite journal| author=Landry GJ| title=Functional outcome of critical limb ischemia. | journal=J Vasc Surg | year= 2007 | volume= 45 Suppl A | issue=  | pages= A141-8 | pmid=17544035 | doi=10.1016/j.jvs.2007.02.052 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17544035  }} </ref>
 
Disability from [[amputation]] or removal of dead tissue
 
Prolonged wound healing or the need for reconstructive surgery, such as [[skin grafting]]


==Prognosis==
==Prognosis==
*There is a possibility of [[recurrence]] of [[critical limb ischemia]]/ [[chronic limb-threatening ischemia]].
*Follow-up after [[revascularization procedures]] is needed for at least two years.<ref name="pmid31159978">{{cite journal| author=Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R | display-authors=etal| title=Global vascular guidelines on the management of chronic limb-threatening ischemia. | journal=J Vasc Surg | year= 2019 | volume= 69 | issue= 6S | pages= 3S-125S.e40 | pmid=31159978 | doi=10.1016/j.jvs.2019.02.016 | pmc=8365864 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31159978  }} </ref>
*[[Gas gangrene]] has higher [[fatality rate]], ranging from 25% to 100%, if [[treatment]] is inadequate or delayed.
*Increased [[age]], several [[comorbidities]] present, and involvement of [[trunk]] lead to a poor [[prognosis]]. <ref name="pmid26631369">{{cite journal| author=Yang Z, Hu J, Qu Y, Sun F, Leng X, Li H | display-authors=etal| title=Interventions for treating gas gangrene. | journal=Cochrane Database Syst Rev | year= 2015 | volume=  | issue= 12 | pages= CD010577 | pmid=26631369 | doi=10.1002/14651858.CD010577.pub2 | pmc=8652263 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26631369  }} </ref>


What to expect depends on where the gangrene is in the body, how much gangrene there is, and the person's overall condition. If treatment is delayed, the gangrene is extensive, or the person has other significant medical problems, they may die.
==References==
==References==


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Latest revision as of 20:15, 28 April 2022

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

Overview

Amputation and death are the most common consequence of critical limb ischemia/ chronic limb-threatening ischemia. [1] Gas gangrene has a higher fatality rate, ranging from 25% to 100%, if treatment is inadequate or delayed. Increased age, several comorbidities present, and involvement of trunk lead to a poor prognosis. [2]

Complications

Prognosis

References

  1. ↑ 1.0 1.1 Elsayed S, Clavijo LC (2015). "Critical limb ischemia". Cardiol Clin. 33 (1): 37–47. doi:10.1016/j.ccl.2014.09.008. PMID 25439329.
  2. ↑ 2.0 2.1 Yang Z, Hu J, Qu Y, Sun F, Leng X, Li H; et al. (2015). "Interventions for treating gas gangrene". Cochrane Database Syst Rev (12): CD010577. doi:10.1002/14651858.CD010577.pub2. PMC 8652263 Check |pmc= value (help). PMID 26631369.
  3. ↑ Landry GJ (2007). "Functional outcome of critical limb ischemia". J Vasc Surg. 45 Suppl A: A141–8. doi:10.1016/j.jvs.2007.02.052. PMID 17544035.
  4. ↑ Conte MS, Bradbury AW, Kolh P, White JV, Dick F, Fitridge R; et al. (2019). "Global vascular guidelines on the management of chronic limb-threatening ischemia". J Vasc Surg. 69 (6S): 3S–125S.e40. doi:10.1016/j.jvs.2019.02.016. PMC 8365864 Check |pmc= value (help). PMID 31159978.
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