Hemorrhagic diathesis: Difference between revisions

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	Hemorrhagic diathesis;
DiseasesDB	1442

VisualWikitext

Latest revision as of 21:13, 10 January 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Bleeding tendency; haemostasis abnormality; hemorrhagic diathesis; bleeding diathesis

Overview

Bleeding diathesis is an unusual susceptibility to bleeding (hemorrhage) due to a defect in the system of coagulation. Several types are distinguished, ranging from mild to lethal.

Causes

Common Causes

Anticoagulation therapy
Hepatopathies
Hereditary coagulopathies
Thrombocyte impairment
Vitamin K deficiency

Causes by Organ System

Cardiovascular	Anaphylactic shock, Bacterial endocarditis, Cyanotic cardiac vitium, Diffuse intravascular coagulation, Large vascular prostheses, Marfan's syndrome, Myocardial infarction, Vascular hemostatic disorder, Vascular purpura, Vasculitis,
Chemical/Poisoning	Bothrop venom, Rattlesnake venom, Viper venom
Dental	No underlying causes
Dermatologic	Henoch-schonlein purpura, Measles, Nonthrombocytopenic purpura, Osler's disease, Scurvy, Senile-atrophic senilis
Drug Side Effect	Anti-aggregation with aspirin, Anticoagulation inhibitors, Cobimetinib, Epoprostenol, Factor viii inhibitors, Propylthiouracil, Ramucirumab, Therapy with cholestyramin, Warfarin
Ear Nose Throat	No underlying causes
Endocrine	Amyloidosis, Chronic hypercortisolism, Cushing's syndrome, Hermansky-pudlak syndrome,
Environmental	No underlying causes
Gastroenterologic	Acute pancreatitis, Biliary cirrhosis, Cirrhosis, Faulty intestinal flora, Liver failure, Severe gastrointestinal bleeding, Severe hepatopathy, Splenomegaly with portal hypertension
Genetic	Ehlers-danlos syndrome, Osteogenesis imperfecta, Pseudoxanthoma elasticum, Wiskott-aldrich syndrome
Hematologic	Ehlers-danlos syndrome, Osteogenesis imperfecta, Pseudoxanthoma elasticum, Wiskott-aldrich syndrome
Iatrogenic	Fibrinolysis therapy, Fibrinolytic fission products, Graft vs. host disease, Grey platelet syndrome, Large operations, Large vascular prostheses,
Infectious Disease	Bacterial endocarditis, Bacterial meningitis, Cephalosporins, Dengue hemorrhagic fever, Dengue shock syndrome, Diptheria, Influenza, Leptospirosis, Malaria, Measles, Rickettsia, Scarlet fever, Scurvy, Sepsis, Syphilis, Toxoplasmosis, Varicella
Musculoskeletal/Orthopedic	Myelodysplasia, Myeloproliferative syndrome
Neurologic	Bacterial meningitis, Cranio cerebral trauma, Large aneurysms, Osler's disease
Nutritional/Metabolic	Avitaminosis c, Cirrhosis, Dietary deficiencies, Malabsorption, Parenteral nutrition, Vitamin k deficiency
Obstetric/Gynecologic	Amniotic fluid embolism, Intrauterine embryo death, Parenteral nutrition, Premature placenta ablation, Septic abortion
Oncologic	Carcinomas, Leukemia, Myelodysplasia, Myeloproliferative syndrome
Ophthalmologic
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Anaphylactic shock
Renal/Electrolyte	Lactic acidosis, Renal failure, Uremia
Rheumatology/Immunology/Allergy	Cystic fibrosis, Dysfibrinogenemia
Sexual	Syphilis
Trauma	Burns, Cranio cerebral trauma, Hypothermia, Intrauterine embryo death
Urologic	Uremia
Miscellaneous	No underlying causes

Causes In Alphabetical Order. ^[1] ^[2]

References

↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

Template:WikiDoc Sources

[1] Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016

[2] Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

[1]

[2]

@@ Line 13: / Line 13: @@
 ==Causes==
+===Common Causes ===
-=== Most Common Causes ===
 * Anticoagulation therapy
 * Hepatopathies
@@ Line 22: / Line 20: @@
 * [[Vitamin K]] deficiency
-=== Causes of Hemorrhagic Diathesis In Alphabetical Order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>===
+===Causes by Organ System===
+{|style="width:80%; height:100px" border="1"
-* Activated blood clotting factors
+|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
-* [[Acute leukemias]]
+|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Anaphylactic shock]],  [[Bacterial endocarditis]],  [[Cyanotic cardiac vitium]],  [[Diffuse intravascular coagulation]],  [[Large vascular prostheses]],  [[Marfan's syndrome]],  [[Myocardial infarction]],  [[Vascular hemostatic disorder]],  [[Vascular purpura]],  [[Vasculitis]],
-* Acute [[Pancreatitis]]
+|-
-* [[Afibrinogenemia]]
+|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
-* [[Alcoholism]]
+|bgcolor="Beige"| [[Bothrop venom]],  [[Rattlesnake venom]],  [[Viper venom]]
-* Amniotic fluid embolism
+|-
-* [[Amyloidosis]]
+|-bgcolor="LightSteelBlue"
-* Anaphylactic shock
+| '''Dental'''
-* Anti-aggregation with aspirin
+|bgcolor="Beige"| No underlying causes
-* Aspirin-like defect
+|-
-* Avitaminosis C
+|-bgcolor="LightSteelBlue"
-* [[Bacterial Endocarditis]]
+| '''Dermatologic'''
-* [[Bacterial Meningitis]]
+|bgcolor="Beige"| [[Henoch-schonlein purpura]],  [[Measles]],  [[Nonthrombocytopenic purpura]],  [[Osler's disease]],  [[Scurvy]],  [[Senile-atrophic senilis]]
-* [[Bernard-Soulier Syndrome]] ([[BSS]])
+|-
-* [[Biliary Cirrhosis]]
+|-bgcolor="LightSteelBlue"
-* [[Burns]]
+| '''Drug Side Effect'''
-* [[Carcinoma]]s
+|bgcolor="Beige"| [[Anti-aggregation with aspirin]],  [[Anticoagulation inhibitors]],  [[Cobimetinib]],  [[Epoprostenol]],  [[Factor viii inhibitors]],  [[Propylthiouracil]],  [[Ramucirumab]],  [[Therapy with cholestyramin]],  [[Warfarin]]
-* [[Cephalosporins]]
+|-
-* [[Chediak-Higashi Syndrome]]
+|-bgcolor="LightSteelBlue"
-* Chronic hypercortisolism
+| '''Ear Nose Throat'''
-* [[Cirrhosis]]
+|bgcolor="Beige"| No underlying causes
-* Coagulation factor deficiency
+|-
-* Consumption coagulopathy
+|-bgcolor="LightSteelBlue"
-* Cranio cerebral trauma
+| '''Endocrine'''
-* [[Cryoglobulinemia]]
+|bgcolor="Beige"| [[Amyloidosis]],  [[Chronic hypercortisolism]],  [[Cushing's syndrome]],  [[Hermansky-pudlak syndrome]],
-* Cyanotic cardiac vitium
+|-
-* Dietary deficiencies
+|-bgcolor="LightSteelBlue"
-* [[Diffuse Intravascular Coagulation]]
+| '''Environmental'''
-* [[Diptheria]]
+|bgcolor="Beige"| No underlying causes
-* [[Disseminated Intravascular Coagulation]] (DIC)
+|-
-* [[Drug]]s
+|-bgcolor="LightSteelBlue"
-* Dysfibrinogenemia
+| '''Gastroenterologic'''
-* [[Ehlers-Danlos Syndrome]]
+|bgcolor="Beige"| [[Acute pancreatitis]],  [[Biliary cirrhosis]],  [[Cirrhosis]],  [[Faulty intestinal flora]],  [[Liver failure]],  [[Severe gastrointestinal bleeding]],  [[Severe hepatopathy]],  [[Splenomegaly with portal hypertension]]
-* Faulty intestinal flora
+|-
-* Fibrinogenolysis
+|-bgcolor="LightSteelBlue"
-* Fibrinolytic fission products
+| '''Genetic'''
-* Fibrinolysis therapy
+|bgcolor="Beige"| [[Ehlers-danlos syndrome]],  [[Osteogenesis imperfecta]],  [[Pseudoxanthoma elasticum]],  [[Wiskott-aldrich syndrome]]
-* [[Folic acid deficiency]]
+|-
-* [[Glanzmann thrombasthenia]]
+|-bgcolor="LightSteelBlue"
-* [[Graft vs. Host Disease]]
+| '''Hematologic'''
-* [[Grey platelet syndrome]]
+|bgcolor="Beige"| [[Ehlers-danlos syndrome]],  [[Osteogenesis imperfecta]],  [[Pseudoxanthoma elasticum]],  [[Wiskott-aldrich syndrome]]
-* Hegglin's anomaly
+|-
-* [[HELLP Syndrome]] ('''H'''emolysis, '''E'''levated '''L'''iver enzymes, '''L'''ow '''P'''latelet count)
+|-bgcolor="LightSteelBlue"
-* [[Hemophilia]] A & B
+| '''Iatrogenic'''
-* [[Henoch-Schonlein purpura]]
+|bgcolor="Beige"| [[Fibrinolysis therapy]],  [[Fibrinolytic fission products]],  [[Graft vs. host disease]],  [[Grey platelet syndrome]],  [[Large operations]],  [[Large vascular prostheses]],
-* [[Hereditary hemorrhagic telangiectasia]]
+|-
-* [[Hermansky-Pudlak Syndrome]]
+|-bgcolor="LightSteelBlue"
-* Hyperglobulinemia
+| '''Infectious Disease'''
-* [[Ddx:Hypothermia|Hypothermia]]
+|bgcolor="Beige"| [[Bacterial endocarditis]],  [[Bacterial meningitis]],  [[Cephalosporins]],  [[Dengue hemorrhagic fever]],  [[Dengue shock syndrome]],  [[Diptheria]],  [[Influenza]],  [[Leptospirosis]],  [[Malaria]],  [[Measles]],  [[Rickettsia]],  [[Scarlet fever]],  [[Scurvy]],  [[Sepsis]],  [[Syphilis]],  [[Toxoplasmosis]],  [[Varicella]]
-* [[Influenza]]
+|-
-* Intrauterine embryo death
+|-bgcolor="LightSteelBlue"
-* [[Lactic acidosis]]
+| '''Musculoskeletal/Orthopedic'''
-* [[Large aneurysms]]
+|bgcolor="Beige"| [[Myelodysplasia]],  [[Myeloproliferative syndrome]]
-* Large operations
+|-
-* Large vascular prostheses
+|-bgcolor="LightSteelBlue"
-* [[Leptospirosis]]
+| '''Neurologic'''
-* [[Leukemia]]
+|bgcolor="Beige"| [[Bacterial meningitis]],  [[Cranio cerebral trauma]],  [[Large aneurysms]],  [[Osler's disease]]
-* [[Malabsorption]]
+|-
-* [[Malaria]]
+|-bgcolor="LightSteelBlue"
-* [[Marfan's Syndrome]]
+| '''Nutritional/Metabolic'''
-* [[Measles]]
+|bgcolor="Beige"| [[Avitaminosis c]],  [[Cirrhosis]],  [[Dietary deficiencies]],  [[Malabsorption]],  [[Parenteral nutrition]],  [[Vitamin k deficiency]]
-* [[Metastases]]
+|-
-* Miscellaneous heritable disorders of connective tissue
+|-bgcolor="LightSteelBlue"
-* [[Myeloproliferative syndrome]]
+| '''Obstetric/Gynecologic'''
-* [[Myelodysplasia]]
+|bgcolor="Beige"| [[Amniotic fluid embolism]],  [[Intrauterine embryo death]],  [[Parenteral nutrition]],  [[Premature placenta ablation]],  [[Septic abortion]]
-* [[Myocardial Infarction]]
+|-
-* Nonthrombocytopenic purpura
+|-bgcolor="LightSteelBlue"
-* [[Osler's Disease]]
+| '''Oncologic'''
-* [[Osteogenesis imperfecta]]
+|bgcolor="Beige"| [[Carcinomas]],  [[Leukemia]],  [[Myelodysplasia]],  [[Myeloproliferative syndrome]]
-* Pachymeningeosis haemorrhagica interna
+|-
-* [[Paraproteinemia]]
+|-bgcolor="LightSteelBlue"
-* Parenteral nutrition
+| '''Ophthalmologic'''
-* [[Pernicious anemia]]
+|bgcolor="Beige"|
-* Plasminogen activators
+|-
-* Pocks
+|-bgcolor="LightSteelBlue"
-* Premature placenta ablation
+| '''Overdose/Toxicity'''
-* Pseudoxanthoma elasticum
+|bgcolor="Beige"| No underlying causes
-* Pupura fulminans
+|-
-* [[Rickettsia]]
+|-bgcolor="LightSteelBlue"
-* [[Scarlet Fever]]
+| '''Psychiatric'''
-* [[Scurvy]]
+|bgcolor="Beige"| No underlying causes
-* Senile-atrophic/purpura senilis
+|-
-* [[Sepsis]]
+|-bgcolor="LightSteelBlue"
-* Septic abortion
+| '''Pulmonary'''
-* Severe gastrointestinal bleeding
+|bgcolor="Beige"| [[Anaphylactic shock]]
-* Severe hepatopathy
+|-
-* [[Ddx:Shock|Shock]]
+|-bgcolor="LightSteelBlue"
-* State after circulatory arrest
+| '''Renal/Electrolyte'''
-* [[Ddx:Splenomegaly|Splenomegaly with portal hypertension]]
+|bgcolor="Beige"| [[Lactic acidosis]],  [[Renal failure]],  [[Uremia]]
-* [[Syphilis]]
+|-
-* [[Telangiectasia]]
+|-bgcolor="LightSteelBlue"
-* Therapy with cholestyramin
+| '''Rheumatology/Immunology/Allergy'''
-* Thrombopathic thrombopenia
+|bgcolor="Beige"| [[Cystic fibrosis]],  [[Dysfibrinogenemia]]
-* [[Thrombasthenia]]
+|-
-* [[Toxoplasmosis]]
+|-bgcolor="LightSteelBlue"
-* [[Uremia]]
+| '''Sexual'''
-* [[Varicella]]
+|bgcolor="Beige"| [[Syphilis]]
-* [[Vasculitis]]
+|-
-* [[Vitamin K deficiency]]
+|-bgcolor="LightSteelBlue"
-* [[Von Willenbrand's Disease]]
+| '''Trauma'''
-* [[Warfarin]]
+|bgcolor="Beige"| [[Burns]],  [[Cranio cerebral trauma]],  [[Hypothermia]],  [[Intrauterine embryo death]]
-* [[Wiskott-Aldrich Syndrome]]
+|-
+|-bgcolor="LightSteelBlue"
-====Contraindicated medications====
+| '''Urologic'''
+|bgcolor="Beige"| [[Uremia]]
-{{MedCondContrAbs
+|-
+|-bgcolor="LightSteelBlue"
-|MedCond = Hemorrhagic diathesis|Ketorolac tromethamine}}
+| '''Miscellaneous'''
+|bgcolor="Beige"| No underlying causes
+|-
+|}
+===Causes In Alphabetical Order. <ref>Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016</ref> <ref>Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X</ref>===
+{{columns-list|
+*[[Activated blood clotting factors]]
+*[[Acute pancreatitis]]
+*[[Afibrinogenemia]]
+*[[Amniotic fluid embolism]]
+*[[Amyloidosis]]
+*[[Anaphylactic shock]]
+*[[Anti-aggregation with aspirin]]
+*[[Anticoagulation inhibitors]]
+*[[Antiphospholipid syndrome]]
+*[[Avitaminosis c]]
+*[[Bacterial endocarditis]]
+*[[Bacterial meningitis]]
+*[[Bernard-soulier syndrome ]]
+*[[Biliary cirrhosis]]
+*[[Bothrop venom]]
+*[[Burns]]
+*[[Carcinomas]]
+*[[Cephalosporins]]
+*[[Chediak-higashi syndrome]]
+*[[Chronic hypercortisolism]]
+*[[Cirrhosis]]
+*[[Coagulation factor deficiency]]
+*[[Cobimetinib]]
+*[[Congenital disorder of glycosylation type 1k]]
+*[[Consumption coagulopathy]]
+*[[Cranio cerebral trauma]]
+*[[Cryoglobulinemia]]
+*[[Cushing's syndrome]]
+*[[Cyanotic cardiac vitium]]
+*[[Cystic fibrosis]]
+*[[Dengue hemorrhagic fever]]
+*[[Dengue shock syndrome]]
+*[[Dextran plasma volume expander]]
+*[[Dietary deficiencies]]
+*[[Diffuse intravascular coagulation]]
+*[[Diptheria]]
+*[[Disseminated intravascular coagulation]]
+*[[Dysfibrinogenemia]]
+*[[Ehlers-danlos syndrome]]
+*[[Epoprostenol]]
+*[[Factor viii inhibitors]]
+*[[Faulty intestinal flora]]
+*[[Fibrinogenolysis]]
+*[[Fibrinolysis therapy]]
+*[[Fibrinolytic fission products]]
+*[[Folic acid deficiency]]
+*[[Glanzmann thrombasthenia]]
+*[[Graft vs. host disease]]
+*[[Grey platelet syndrome]]
+*[[Hegglin's anomaly]]
+*[[Hellp syndrome ]]
+*[[Hemophilia ]]
+*[[Henoch-schonlein purpura]]
+*[[Hereditary hemorrhagic telangiectasia]]
+*[[Hermansky-pudlak syndrome]]
+*[[Hyperglobulinemia]]
+*[[Hyperviscosity]]
+*[[Hypothermia]]
+*[[Influenza]]
+*[[Intrauterine embryo death]]
+*[[Lactic acidosis]]
+*[[Large aneurysms]]
+*[[Large operations]]
+*[[Large vascular prostheses]]
+*[[Leptospirosis]]
+*[[Leukemia]]
+*[[Liver failure]]
+*[[Malabsorption]]
+*[[Malaria]]
+*[[Marfan's syndrome]]
+*[[Measles]]
+*[[Miscellaneous heritable disorders of connective tissue]]
+*[[Myelodysplasia]]
+*[[Myeloproliferative syndrome]]
+*[[Myocardial infarction]]
+*[[Nonthrombocytopenic purpura]]
+*[[Osler's disease]]
+*[[Osteogenesis imperfecta]]
+*[[Pachymeningeosis haemorrhagica interna]]
+*[[Paraproteinemia]]
+*[[Parenteral nutrition]]
+*[[Pernicious anemia]]
+*[[Plasminogen activators]]
+*[[Platelet dysfunction ]]
+*[[Pocks]]
+*[[Premature placenta ablation]]
+*[[Propylthiouracil]]
+*[[Pseudoxanthoma elasticum]]
+*[[Pupura fulminans]]
+*[[Ramucirumab]]
+*[[Rattlesnake venom]]
+*[[Renal failure]]
+*[[Rickettsia]]
+*[[Scarlet fever]]
+*[[Scurvy]]
+*[[Senile-atrophic senilis]]
+*[[Sepsis]]
+*[[Septic abortion]]
+*[[Severe gastrointestinal bleeding]]
+*[[Severe hepatopathy]]
+*[[Shock]]
+*[[Splenomegaly with portal hypertension]]
+*[[Syphilis]]
+*[[Telangiectasia]]
+*[[Therapy with cholestyramin]]
+*[[Thrombasthenia]]
+*[[Thrombocytopenia]]
+*[[Thrombopathic thrombopenia]]
+*[[Toxoplasmosis]]
+*[[Uremia]]
+*[[Varicella]]
+*[[Vascular hemostatic disorder]]
+*[[Vascular purpura]]
+*[[Vasculitis]]
+*[[Viper venom]]
+*[[Vitamin k deficiency]]
+*[[Von willenbrand's disease]]
+*[[Waldenström macroglobulinaemia]]
+*[[Warfarin]]
+*[[Wiskott-aldrich syndrome]]
+}}
 == References ==