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'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{CMG}}
{{CMG}}; {{AE}} {{YD}}, {{Hudakarman}} {{RT}}, {{Tamar}}


{{SK}} American trypanosomiasis; Trypanosoma cruzi infection
{{SK}} Chagas' disease; American trypanosomiasis; Trypanosoma cruzi infection


==[[Chagas disease overview|Overview]]==
==[[Chagas disease overview|Overview]]==


==[[Chagas disease historical perspective|Historical Perspective]]==
==[[Chagas disease historical perspective|Historical Perspective]]==
==[[Chagas disease classification|Classification]]==


==[[Chagas disease pathophysiology|Pathophysiology]]==
==[[Chagas disease pathophysiology|Pathophysiology]]==
Line 27: Line 29:


==[[Chagas disease risk factors|Risk Factors]]==
==[[Chagas disease risk factors|Risk Factors]]==
=[[Chagas disease screening|Screening]]==


==[[Chagas disease natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
==[[Chagas disease natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


==Diagnosis==
==[[Diagnosis]]==
[[Chagas disease history and symptoms|History and Symptoms]] | [[Chagas disease physical examination|Physical Examination]] | [[Chagas disease laboratory findings|Laboratory Findings]] | [[Chagas disease electrocardiogram|Electrocardiogram]] | [[Chagas disease other diagnostic studies|Other Diagnostic Studies]]
 
[[Chagas disease diagnostic criteria|Diagnostic Criteria]] | [[Chagas disease history and symptoms|History and Symptoms]] | [[Chagas disease physical examination | Physical Examination]] | [[Chagas disease laboratory findings | Laboratory findings]] | [[Chagas disease electrocardiogram | Electrocardiogram]] | [[Chagas disease x ray|X-ray]] | [[Chagas disease electrocardiogram | Electrocardiogram]] | [[Chagas disease  echocardiography and ultrasound|Echocardiography and Ultrasound]] |[[Chagas disease CT scan | CT scan]] | [[Chagas disease MRI | MRI]] | [[Chagas disease other imaging findings|Other Imaging Findings]] | [[Chagas disease other diagnostic studies|Other diagnostic studies]]
 
==[[Treatment]]==


==Treatment==
[[Chagas disease medical therapy|Medical Therapy]] | [[Chagas disease surgery|Surgery]] | [[Chagas disease primary prevention|Primary Prevention]] | [[Chagas disease secondary prevention|Secondary Prevention]] | [[Chagas disease cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Chagas disease future or investigational therapies|Future or Investigational Therapies]]
[[Chagas disease medical therapy|Medical Therapy]] | [[Chagas disease surgery|Surgery]] | [[Chagas disease primary prevention|Primary Prevention]] | [[Chagas disease secondary prevention|Secondary Prevention]] | [[Chagas disease cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Chagas disease future or investigational therapies|Future or Investigational Therapies]]


==Case Studies==
==Case Studies==
[[Chagas disease case study one|Case #1]]
[[Chagas disease case study one|Case #1]]
==Life Cycle==
<gallery widths=400px>
AmerTryp_LifeCycle.gif | An infected triatomine insect vector (or "kissing" bug) takes a blood meal and releases trypomastigotes in its feces near the site of the bite wound. Trypomastigotes enter the host through the wound or through intact mucosal membranes, such as the conjunctiva (1). Common triatomine vector species for trypanosomiasis belong to the genera Triatoma, Rhodnius, and Panstrongylus. Inside the host, the trypomastigotes invade cells near the site of inoculation, where they differentiate into intracellular amastigotes (2). The amastigotes multiply by binary fission (3) and differentiate into trypomastigotes, and then are released into the circulation as bloodstream trypomastigotes (4). Trypomastigotes infect cells from a variety of tissues and transform into intracellular amastigotes in new infection sites. Clinical manifestations can result from this infective cycle. The bloodstream trypomastigotes do not replicate (different from the African trypanosomes). Replication resumes only when the parasites enter another cell or are ingested by another vector. The "kissing" bug becomes infected by feeding on human or animal blood that contains circulating parasites (5). The ingested trypomastigotes transform into epimastigotes in the vector's midgut (6). The parasites multiply and differentiate in the midgut (7) and differentiate into infective metacyclic trypomastigotes in the hindgut (8). Trypanosoma cruzi can also be transmitted through blood transfusions, organ transplantation, transplacentally, and in laboratory accidents. <br> [http://www.cdc.gov/dpdx/trypanosomiasisAmerican/index.html <font size="-2">''Adapted from CDC''</font>]
</gallery>
==Related Chapters==
*[[Tropical disease]]
*[[Drugs for Neglected Diseases Initiative]]
* Distinguish from: [[Chaga mushroom]]


{{Protozoal diseases}}
{{Protozoal diseases}}
{{Link FA|pl}}
[[ar:شاجاس]]
[[ca:Malaltia de Chagas]]
[[de:Chagas-Krankheit]]
[[es:Enfermedad de Chagas]]
[[fr:Maladie de Chagas]]
[[it:Malattia di Chagas]]
[[lt:Čagaso liga]]
[[ms:Penyakit Cagas]]
[[nl:Ziekte van Chagas]]
[[ja:シャーガス病]]
[[pt:Doença de Chagas]]
[[sv:Chagas sjukdom]]
[[pl:Choroba Chagasa]]


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[[Category:Mature chapter]]
[[Category:Gastroenterology]]
[[Category:Cardiology]]

Latest revision as of 23:25, 15 October 2020

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Chagas disease
Photomicrograph of Giemsa-stained Trypanosoma cruzi crithidia (CDC)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D., Huda A. Karman, M.D. Raviteja Guddeti, M.B.B.S. [2], Tamar Sifri [3]

Synonyms and keywords: Chagas' disease; American trypanosomiasis; Trypanosoma cruzi infection

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Chagas disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening=

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria | History and Symptoms | Physical Examination | Laboratory findings | Electrocardiogram | X-ray | Electrocardiogram | Echocardiography and Ultrasound | CT scan | MRI | Other Imaging Findings | Other diagnostic studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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