Angiostrongylus cantonensis: Difference between revisions

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{{Angiostrongyliasis}}
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==Overview==
==Overview==


'''''Angiostrongylus cantonensis''''' is a [[Tapeworm infection|parasitic]] [[nematode]] (roundworm) that causes [[Angiostrongyliasis]], the most common cause of [[eosinophilic meningitis]] in [[Southeast Asia]] and the [[Pacific Basin]].<ref name=Baheti2008>{{Cite doi|10.1136/jnnp.2007.122093}}</ref> The nematode commonly resides in the pulmonary arteries of rats, giving it the nickname the '''rat lungworm'''. [[Snail]]s are the primary intermediate hosts, where larvae develop until they are infective.   
'''''Angiostrongylus cantonensis''''' is a [[Tapeworm infection|parasitic]] [[nematode]] (roundworm) that causes [[Angiostrongyliasis]], the most common cause of [[eosinophilic meningitis]] in [[Southeast Asia]] and the [[Pacific Basin]]. The nematode commonly resides in the pulmonary arteries of rats, giving it the nickname the '''rat lungworm'''. [[Snail]]s are the primary intermediate hosts, where larvae develop until they are infective.   


Humans are incidental hosts of this roundworm, and may become infected through ingestion of larvae in raw or undercooked snails or other vectors, or from contaminated water and vegetables. The larvae are then transported via the blood to the [[central nervous system]] (CNS), where they are the most common cause of [[eosinophilic meningitis]], a serious condition that can lead to death or permanent brain and nerve damage.<ref name=HuaLi2008>{{Cite pmid|18840746}}</ref> Identified in 1964, Angiostrongyliasis is an infection of increasing public health importance as [[globalization]] contributes to the geographic spread of the disease.
Humans are incidental hosts of this roundworm, and may become infected through ingestion of larvae in raw or undercooked snails or other vectors, or from contaminated water and vegetables. The larvae are then transported via the blood to the [[central nervous system]] (CNS), where they are the most common cause of [[eosinophilic meningitis]], a serious condition that can lead to death or permanent brain and nerve damage. Identified in 1964, Angiostrongyliasis is an infection of increasing public health importance as [[globalization]] contributes to the geographic spread of the disease.


==History==
==Infectious agent==


Nematodes suspected to be ''Angiostrongylus cantonensis'' were first identified in the [[cerebrospinal fluid]] of a patient with eosinophilic meningitis by Nomura and Lim in [[Taiwan]] in 1944. They called the parasite ''Haemostrongylus ratti'', and noted that raw food eaten by the patient may have been contaminated by rats. Their paper, however, was not translated from the original Japanese into English until just after the parasite had been recognized in 1964, so their discovery was not widely recognized.
''Angiostrongylus cantonensis'' is a [[parasitic worm|helminth]] of the [[phylum]] [[nematode|Nematoda]], [[order (biology)|order]] [[Strongylida]], and [[superfamily (zoology)|superfamily]] [[Metastrongyloidea]]. Nematodes are roundworms characterized by a tough outer cuticle, unsegmented bodies, and a fully developed [[Human gastrointestinal tract|gastrointestinal tract]]. The order Strongylida includes hookworms and lungworms. Metastrongyloidea are characterized as long, slender, threadlike worms that reside in the lungs of the definitive host.<ref name=Cambridge>[http://www.path.cam.ac.uk/~schisto/helminth_taxonomy/taxonomy_nematoda.html "Helminth Taxonomy - Phylum Nematoda"], Schistosomiasis Research Group, accessed 26 February 2009.</ref> ''[[Angiostrongylus costaricensis]]'' is a closely related worm that causes intestinal Angiostrongyliasis in Central and South America.


In 1955, Mackerass and Sanders identified the life cycle of the worm in rats, defining snails and slugs as the intermediate host and noting the path of transmission through the blood, brain, and lungs in rats.
''A. cantonensis'' is a nematode roundworm with 3 outer protective collagen layers, and a simple stomal opening or mouth with no lips or buccal cavity leading to a fully developed gastrointestinal tract. Males have a small copulatory bursa at the posterior.  Females have a “[[barber pole]]” shape down the middle of the body, which is created by the twisting together of the intestine and uterine tubules. The worms are long and slender - males are 15.9-19&nbsp;mm in length, and females are 21-25&nbsp;mm in length.<ref name="Michigan">http://animaldiversity.ummz.umich.edu/site/accounts/information/Angiostrongylus_cantonensis.html, Accessed 2/26/09</ref>


==Infectious agent==
==Life cycle==
 
The adult form of ''A. cantonensis'' resides in the pulmonary arteries of rodents, where it reproduces.  After the eggs hatch in the arteries, larvae migrate up the pharynx and are then swallowed again by the rodent and passed in the stool. These first stage larvae then penetrate or are swallowed by snail intermediate hosts, where they transform into second stage larvae and then into third stage infective larvae.  Humans and rats acquire the infection when they ingest contaminated snails or paratenic (transport) hosts including prawns, crabs, and frogs, or raw vegetables containing material from these intermediate and paratenic hosts.  After passing through the gastrointestinal tract, the worms enter circulation.  In rats, the larvae then migrate to the meninges and develop for about a month before migrating to the pulmonary arteries, where they fully develop into adults.
 
Humans are incidental hosts; the larvae cannot reproduce in humans and therefore humans do not contribute to the ''A. cantonensis'' life cycle.  In humans, the circulating larvae migrate to the meninges, but do not move on to the lungs. Sometimes the larvae will develop into the adult form in the brain and CSF, but  they quickly die, inciting the inflammatory reaction that causes symptoms of infection.
 
<gallery widths=200px>


[[File:Angiostrongylus cantonensis 2.png|thumb|Tail of adult male of ''Angiostrongylus cantonensis'', showing copulatory bursa and long spicules (arrows). Scale bar is 85 µm.]]
Angiostrong_LifeCycle.gif | Angiostrongyliasis Life Cycle <br> [http://www.cdc.gov/dpdx/angiostrongyliasis/index.html <font size="-2">''Adapted from CDC''</font>]
''Angiostrongylus cantonensis'' is a [[parasitic worm|helminth]] of the [[phylum]] [[nematode|Nematoda]], [[order (biology)|order]] [[Strongylida]], and [[superfamily (zoology)|superfamily]] [[Metastrongyloidea]]. Nematodes are roundworms characterized by a tough outer cuticle, unsegmented bodies, and a fully developed [[Human gastrointestinal tract|gastrointestinal tract]]. The order Strongylida includes hookworms and lungworms. Metastrongyloidea are characterized as long, slender, threadlike worms that reside in the lungs of the definitive host.<ref name=Cambridge>[http://www.path.cam.ac.uk/~schisto/helminth_taxonomy/taxonomy_nematoda.html "Helminth Taxonomy - Phylum Nematoda"], Schistosomiasis Research Group, accessed 26 February 2009.</ref> ''[[Angiostrongylus costaricensis]]'' is a closely related worm that causes intestinal Angiostrongyliasis in Central and South America.


==Epidemiology==
</gallery>


Following World War II, ''A. cantonensis'' spread throughout Southeast Asia and Western Pacific Islands including [[Australia]], [[Melanesia]], [[Micronesia]], and [[Polynesia]]. Cases were soon reported in the following nations: [[New Caledonia]], the [[Philippines]],  [[Rarotonga]], [[Saipan]], [[Sumatra]], Taiwan and [[Tahiti]]. In the 1960s even more cases were reported from the region from locations such as: [[Cambodia]], [[Guam]], [[Hawaii]], [[Java]], [[Thailand]], [[Sarawak]], [[Vietnam]] and the New Hebrides ([[Vanuatu]]).<ref name="urlwww.dhh.louisiana.gov">[http://www.dhh.louisiana.gov/offices/miscdocs/docs-249/Manual/MeningitisEosinophilicManual.pdf "EOSINOPHILIC MENINGITIS"]. Revised 28 February 2006, accessed 1 June 2011.</ref>
==Reservoirs==


In 1961, an epidemiological study of eosinophilic meningitis in humans was conducted by Rosen, Laigret, and Bories, who hypothesized that the parasite causing these infections was carried by fish. However Alicata noted that raw fish was consumed by large numbers of people in Hawaii without apparent consequences, and patients presenting with meningitis symptoms had a history of eating raw snails or prawns in the weeks before presenting with symptoms.  This observation along with epidemiology and autopsy of infected brains confirmed ''A. cantonensis'' infection in humans as the cause of the majority of eosinophilic meningitis cases in Southeast Asia and the Pacific Islands.<ref name=Alicata1991>Alicata J. E. (1991). "The Discovery of ''Angiostrongylus cantonensis'' as a Cause of Human Eosinophilic Meningitis". ''[[Parasitology Today]]'' '''7'''(6): 151-153.</ref>
Rats are the definitive host and the main reservoir for ''A. cantonensis,'' though other small mammals may also become infected. While ''angiostrongylus'' can infect humans, humans do not act as reservoirs since the worm cannot reproduce in humans and therefore humans cannot contribute to their life cycle.


Since then, cases of ''A. cantonensis'' infestations have appeared in  [[American Samoa]], [[Australia]], [[Hong Kong]], [[Bombay]], [[Fiji]], [[Hawaii]], [[Honshu]], [[India]], [[Kyushu]], [[New Britain]], [[Okinawa]], [[Ryukyu Islands]], [[Western Samoa]] and most recently mainland [[China]]. Other sporadic occurrences of the parasite in its rat hosts have been reported in [[Cuba]], [[Egypt]], [[Louisiana]], [[Madagascar]], [[Nigeria]], [[New Orleans]] and [[Puerto Rico]]<ref name="urlwww.dhh.louisiana.gov"/>
==Vectors==


In recent years, the parasite has been shown to be proliferating at an alarming rate due to modern food consumption trends and global transportation of food products. Scientists are calling for a more thorough study of the epidemiology of ''A. cantonensis'', stricter food safety policies, and the increase of knowledge on how to properly consume products commonly infested by the parasite.<ref name="Lv 2008">Lv S., Zhang Y., Steinmann P. &, Zhou X.-N. (2008). "Emerging angiostrongyliasis in mainland China". ''[[Emerging Infectious Diseases]]'' '''14'''(1): 161-164. [http://www.cdc.gov/EID/content/14/1/161.htm HTM].</ref>
''A. cantonensis'' has many vectors, with the most common being several species of snails, including the giant African land snail (''Achatina fulica'') in the Pacific islands and snails of the genus ''Pila'' in Thailand and Malaysia.  The golden apple snail, ''A. canaliculatus'', is the most important vector in areas of China. Freshwater prawns, crabs, or other [[paratenic]], or transport, hosts can also act as vectors.


==Hosts==
==Hosts==
Intermediate hosts of larvae of for ''Angiostrongylus cantonensis'' include:
Intermediate hosts of larvae of for ''Angiostrongylus cantonensis'' include:
* land snails: ''[[Thelidomus aspera]]'' from Jamaica,<ref name="Lindo">Lindo J. F., Waugh C., Hall J., Cunningham-Myrie C., Ashley D., Eberhard M. L., Sullivan J. J.,  Bishop H. S., Robinson D. G., Holtz T. & Robinson R. D. (2002). "Enzootic ''Angiostrongylus cantonensis'' in Rats and Snails after an Outbreak of Human Eosinophilic Meningitis, Jamaica". ''[[Emerging Infectious Diseases]]'' '''8'''(3): 324-326. [http://www.cdc.gov/ncidod/eid/vol8no3/01-0316.htm HTM].</ref> ''[[Achatina fulica]]'',<ref name="Lv 2008"/><ref name="Lv2009"/><ref name="Asaro"/><ref name="airforcemedicine 2001"/> ''[[Satsuma mercatoria]]'',<ref name="Asaro"/><ref name="airforcemedicine 2001"/> ''[[Acusta despecta]]'',<ref name="Asaro"/><ref name="airforcemedicine 2001"/> ''[[Bradybaena brevispira]]'',<ref name="Lv 2008"/> ''[[Bradybaena circulus]]''<ref name="Asaro"/> ''[[Bradybaena ravida]]'',<ref name="Lv 2008"/> ''[[Bradybaena similaris]]'',<ref name="Lv 2008"/> ''[[Plectotropis appanata]]''<ref name="Lv 2008"/> and ''[[Parmarion martensi]]'' from Okinawa<ref name="Asaro"/> and from Hawaii,<ref name="Hollingsworth">{{Cite doi| 10.2984/1534-6188(2007)61[457:DOPCMP]2.0.CO;2}}.</ref> ''[[Camaena cicatricosa]]'',<ref name="Lv 2008"/> ''[[Trichochloritis rufopila]]'',<ref name="Lv 2008"/> ''[[Trichochloritis hungerfordianus]]''<ref name="Lv 2008"/> and ''[[Cyclophorus (gastropod)|Cyclophorus]]'' spp.<ref name="airforcemedicine 2001">(20 June 2001). "Land snail infection rates for the human parasitic nematode, ''Angiostrongylus cantonensis'' (rat lung worm) with notes on snail and parasite biology and distribution on Kadena AB, Okinawa Japan. Consultative Letter, IERA-DO-BR-CL-2001-0049." ''MEMORANDUM FOR 18 MDG/SGPM'', [[Department of the Air Force]], 11 pp. [http://airforcemedicine.afms.mil/idc/groups/public/documents/afms/ctb_020408.pdf PDF].</ref>
* land snails: ''[[Thelidomus aspera]]'' from Jamaica,<ref name="Lindo">Lindo J. F., Waugh C., Hall J., Cunningham-Myrie C., Ashley D., Eberhard M. L., Sullivan J. J.,  Bishop H. S., Robinson D. G., Holtz T. & Robinson R. D. (2002). "Enzootic ''Angiostrongylus cantonensis'' in Rats and Snails after an Outbreak of Human Eosinophilic Meningitis, Jamaica". ''[[Emerging Infectious Diseases]]'' '''8'''(3): 324-326. [http://www.cdc.gov/ncidod/eid/vol8no3/01-0316.htm HTM].</ref> ''[[Achatina fulica]]'',<ref name="Lv2009"/><ref name="Asaro"/><ref name="airforcemedicine 2001"/> ''[[Satsuma mercatoria]]'',<ref name="Asaro"/><ref name="airforcemedicine 2001"/> ''[[Acusta despecta]]'',<ref name="Asaro"/><ref name="airforcemedicine 2001"/> ''[[Bradybaena brevispira]]'', ''[[Bradybaena circulus]]''<ref name="Asaro"/> ''[[Bradybaena ravida]]'', ''[[Bradybaena similaris]]'', ''[[Plectotropis appanata]]'' and ''[[Parmarion martensi]]'' from Okinawa<ref name="Asaro"/> and from Hawaii,<ref name="Hollingsworth">{{Cite doi| 10.2984/1534-6188(2007)61[457:DOPCMP]2.0.CO;2}}.</ref> ''[[Camaena cicatricosa]]'', ''[[Trichochloritis rufopila]]'', ''[[Trichochloritis hungerfordianus]]'' and ''[[Cyclophorus (gastropod)|Cyclophorus]]'' spp.<ref name="airforcemedicine 2001">(20 June 2001). "Land snail infection rates for the human parasitic nematode, ''Angiostrongylus cantonensis'' (rat lung worm) with notes on snail and parasite biology and distribution on Kadena AB, Okinawa Japan. Consultative Letter, IERA-DO-BR-CL-2001-0049." ''MEMORANDUM FOR 18 MDG/SGPM'', [[Department of the Air Force]], 11 pp. [http://airforcemedicine.afms.mil/idc/groups/public/documents/afms/ctb_020408.pdf PDF].</ref>
* freshwater snails: ''[[Pila (gastropod)|Pila]]'' spp.,<ref name="Lv2009"/> ''[[Pomacea canaliculata]]'',<ref name="Lv 2008"/><ref name="Lv2009">{{Cite PMID|19771154}}</ref> ''[[Cipangopaludina chinensis]]'',<ref name="Lv 2008"/> ''[[Bellamya aeruginosa]]''<ref name="Lv 2008"/> and ''[[Bellamya quadrata]]''<ref name="Lv 2008"/>
* freshwater snails: ''[[Pila (gastropod)|Pila]]'' spp.,<ref name="Lv2009"/> ''[[Pomacea canaliculata]]'',<ref name="Lv2009">{{Cite PMID|19771154}}</ref> ''[[Cipangopaludina chinensis]]'', ''[[Bellamya aeruginosa]]'' and ''[[Bellamya quadrata]]''
* slugs: ''[[Limax maximus]]'',<ref>{{Cite pmid|14558868}}</ref> ''[[Limax flavus]]''<ref name="Lv 2008"/> ''[[Deroceras laeve]]'',<ref name="Lv 2008"/><ref name="Högger 2003"/> ''[[Deroceras reticulatum]]'',<ref name="Högger 2003"/> ''[[Veronicella alte]]'',<ref name="Asaro"/> =? ''[[Laevicaulis alte]]'',<ref name="Lv 2008"/><ref name="Högger 2003"/> ''[[Sarasinula plebeia]]''<!-- listed as Vaginulus plebeius-->,<ref name="Högger 2003">Högger C. H. (update 25 March 2003). "Antagonists of Slugs and Snails. A Bibliography of Sources and a List of Citations grouped according to Taxon of the Antagonists". [http://web.archive.org/web/20071214020100/http://homepage.sunrise.ch/mysunrise/choegger/Slugs/Antagonists.html in web Archive].</ref> ''[[Vaginulus yuxjsjs]]'',<ref name="Lv 2008"/> ''[[Lehmannia valentiana]]'',<ref name="Asaro"/> ''[[Phiolomycus bilineatus]]'',<ref name="Lv 2008"/> ''[[Macrochlamys loana]]'',<ref name="Lv 2008"/> ''[[Meghimatium bilineatum]]''<ref name="Lv 2008"/> and probably other species of slugs.
* slugs: ''[[Limax maximus]]'',<ref>{{Cite pmid|14558868}}</ref> ''[[Limax flavus]]'' ''[[Deroceras laeve]]'',<ref name="Högger 2003"/> ''[[Deroceras reticulatum]]'',<ref name="Högger 2003"/> ''[[Veronicella alte]]'',<ref name="Asaro"/> =? ''[[Laevicaulis alte]]'',<ref name="Högger 2003"/> ''[[Sarasinula plebeia]]''<!-- listed as Vaginulus plebeius-->,<ref name="Högger 2003">Högger C. H. (update 25 March 2003). "Antagonists of Slugs and Snails. A Bibliography of Sources and a List of Citations grouped according to Taxon of the Antagonists". [http://web.archive.org/web/20071214020100/http://homepage.sunrise.ch/mysunrise/choegger/Slugs/Antagonists.html in web Archive].</ref> ''[[Vaginulus yuxjsjs]]'', ''[[Lehmannia valentiana]]'',<ref name="Asaro"/> ''[[Phiolomycus bilineatus]]'', ''[[Macrochlamys loana]]'', ''[[Meghimatium bilineatum]]'' and probably other species of slugs.


Definitive host of ''Angiostrongylus cantonensis'' include wild rodents, especially the brown rat (''[[Rattus norvegicus]]'')<ref name="Lindo"/> and the black rat (''[[Rattus rattus]]'').<ref name="Lindo"/>
Definitive host of ''Angiostrongylus cantonensis'' include wild rodents, especially the brown rat (''[[Rattus norvegicus]]'')<ref name="Lindo"/> and the black rat (''[[Rattus rattus]]'').<ref name="Lindo"/>
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Paratenic hosts of ''Angiostrongylus cantonensis'' include: predatory land flatworm ''[[Platydemus manokwari]]''<ref name="Asaro">Asato R., Taira K., Nakamura M., Kudaka J., Itokazu K. & Kawanaka M. (2004) "[http://www.nih.go.jp/niid/JJID/57/184.pdf Changing Epidemiology of Angiostrongyliasis Cantonensis in Okinawa Prefecture, Japan]". ''[[Japanese Journal of Infectious Diseases]]'' '''57''': 184-186. [http://www.nih.go.jp/JJID/57/184.html article] </ref> and amphibians ''[[Bufo asiaticus]]'',<ref name="Asaro"/> ''[[Rana catesbeiana]]'',<ref name="Asaro"/> ''[[Rhacophorus leucomystax]]''<ref name="Asaro"/> and ''[[Rana limnocharis]]''.<ref name="Asaro"/>
Paratenic hosts of ''Angiostrongylus cantonensis'' include: predatory land flatworm ''[[Platydemus manokwari]]''<ref name="Asaro">Asato R., Taira K., Nakamura M., Kudaka J., Itokazu K. & Kawanaka M. (2004) "[http://www.nih.go.jp/niid/JJID/57/184.pdf Changing Epidemiology of Angiostrongyliasis Cantonensis in Okinawa Prefecture, Japan]". ''[[Japanese Journal of Infectious Diseases]]'' '''57''': 184-186. [http://www.nih.go.jp/JJID/57/184.html article] </ref> and amphibians ''[[Bufo asiaticus]]'',<ref name="Asaro"/> ''[[Rana catesbeiana]]'',<ref name="Asaro"/> ''[[Rhacophorus leucomystax]]''<ref name="Asaro"/> and ''[[Rana limnocharis]]''.<ref name="Asaro"/>


In 2004, a captive [[Yellow-tailed Black Cockatoo]] (''Calyptorhynchus funereus'') and two free-living [[Tawny Frogmouth]]s (''Podargus strigoides'') suffering neurological symptoms were shown to have the parasite. They were the first non-mammalian hosts discovered for the organism.<ref>{{Cite doi|10.1647/2004-024.1}}</ref>
In 2004, a captive [[Yellow-tailed Black Cockatoo]] (''Calyptorhynchus funereus'') and two free-living [[Tawny Frogmouth]]s (''Podargus strigoides'') suffering neurological symptoms were shown to have the parasite. They were the first non-mammalian hosts discovered for the organism.


==Pathogenesis of human angiostrongylosis==
==Transmission==


The presence of parasitic worms burrowed in the neural tissue of the human CNS will cause obvious complications. All of the following will result in damage to the CNS:
Transmission of the parasite is usually from eating raw or undercooked snails or other vectors. Infection is also frequent from ingestion of contaminated water or unwashed salad that may contain small snail and slugs, or have been contaminated by them. Therefore it is very important to avoid raw snails, wash and cook vegetables thoroughly, and avoid open water sources that may be contaminated.


# Direct mechanical damage to neural tissue from the worms' motion
==Incubation period==
# Toxic by-products such as nitrogenous waste
 
# Antigens released by dead and living parasites
The incubation period in humans is usually from 1 week to 1 month after infection, and can be as long as 47 days.  This interval varies, since humans are intermediate hosts and, the life cycle does not continue predictably as it would in a rat.


==Eosinophilic meningitis==
==Eosinophilic meningitis==
{{See also|Eosinophilic meningitis}}


Although the clinical disease caused by Angiostrongylus invasion into the central nervous system is commonly referred to as "eosinophilic meningitis" the actual pathophysiology is of a meningoencephalitis with invasion not just of the meninges, or superficial lining of the brain, but also deeper brain tissue.  Initial invasion through the lining of the brain, the meninges, may cause a typical inflammation of the meninges and a classic meningitis picture of headache, stiff neck and often fever.  The parasites subsequently invade deeper into the brain tissue, causing specific localizing neurologic symptoms depending on where in the brain [[parenchyma]] they migrate. Neurologic findings and symptoms wax and wane as initial damage is done by the physical in-migration of the worms and secondary damage is done by the inflammatory response to the presence of dead and dying worms. This inflammation can lead in the short term to paralysis, bladder dysfunction, visual disturbance and coma and in the long term to permanent nerve damage, mental retardation, nerve damage, permanent brain damage or death.  
Although the clinical disease caused by Angiostrongylus invasion into the central nervous system is commonly referred to as "eosinophilic meningitis" the actual pathophysiology is of a meningoencephalitis with invasion not just of the meninges, or superficial lining of the brain, but also deeper brain tissue.  Initial invasion through the lining of the brain, the meninges, may cause a typical inflammation of the meninges and a classic meningitis picture of headache, stiff neck and often fever.  The parasites subsequently invade deeper into the brain tissue, causing specific localizing neurologic symptoms depending on where in the brain [[parenchyma]] they migrate. Neurologic findings and symptoms wax and wane as initial damage is done by the physical in-migration of the worms and secondary damage is done by the inflammatory response to the presence of dead and dying worms. This inflammation can lead in the short term to paralysis, bladder dysfunction, visual disturbance and coma and in the long term to permanent nerve damage, mental retardation, nerve damage, permanent brain damage or death.  


Eosinophilic meningitis is commonly defined by the increased number of eosinophils in the cerebrospinal fluid (CSF). In most cases, Eosinophil levels rise to 10 or more eosinophils per μL in the cerebrospinal fluid, accounting for at least 10% of the total CSF leukocyte count.<ref name="urlwww.dhh.louisiana.gov"/> The chemical analysis of the CSF typically resembles the findings in "[[aseptic meningitis]]" with slightly elevated protein levels, normal glucose levels and negative bacterial cultures.  Presence of a significantly decreased glucose on CSF analysis is an indicator of severe meningoencephalitis and may indicate a poor prognosis.  Initial CSF analysis early in the disease process may occasionally show no increase of eosinophils only to have classical increases in eosinophils in subsequest spinal fluid analysis. Caution should be advised in using eosinophilic meningitis as the only criteria for diagnosing angiostrongylus infestation in someone with classic symptoms as the disease evolves with the migration of the worms into the central nervous system.  
Eosinophilic meningitis is commonly defined by the increased number of eosinophils in the cerebrospinal fluid (CSF). In most cases, Eosinophil levels rise to 10 or more eosinophils per μL in the cerebrospinal fluid, accounting for at least 10% of the total CSF leukocyte count. The chemical analysis of the CSF typically resembles the findings in "[[aseptic meningitis]]" with slightly elevated protein levels, normal glucose levels and negative bacterial cultures.  Presence of a significantly decreased glucose on CSF analysis is an indicator of severe meningoencephalitis and may indicate a poor prognosis.  Initial CSF analysis early in the disease process may occasionally show no increase of eosinophils only to have classical increases in eosinophils in subsequest spinal fluid analysis. Caution should be advised in using eosinophilic meningitis as the only criteria for diagnosing angiostrongylus infestation in someone with classic symptoms as the disease evolves with the migration of the worms into the central nervous system.  


Eosinophils are specialized white blood cells of the granulocytic cell line which contain granules in their cytoplasm. These granules contain proteins that are toxic to parasites. When these granules degranulate, or break down, chemicals are released that combat parasites such as ''A. cantonensis''. Eosinophils, which are located throughout the body, are guided to sites of inflammation by chemokines when the body is infested with parasites such as ''A. cantonensis''. Once at the site of inflammation, Type 2 cytokines are released from helper T cells, which communicate with the Eosinophils, signaling them to activate. Once activated, eosinophils can begin the process of degranulation, releasing their toxic proteins in the fight against the foreign parasite.
Eosinophils are specialized white blood cells of the granulocytic cell line which contain granules in their cytoplasm. These granules contain proteins that are toxic to parasites. When these granules degranulate, or break down, chemicals are released that combat parasites such as ''A. cantonensis''. Eosinophils, which are located throughout the body, are guided to sites of inflammation by chemokines when the body is infested with parasites such as ''A. cantonensis''. Once at the site of inflammation, Type 2 cytokines are released from helper T cells, which communicate with the Eosinophils, signaling them to activate. Once activated, eosinophils can begin the process of degranulation, releasing their toxic proteins in the fight against the foreign parasite.


===Clinical symptoms===
==References==
 
The clinical symptoms of eosinophilic meningitis are as follows:
* fever is often minor or absent but the presence of high fever suggests severe disease.
* headaches- a bitemporal character in the frontal or occipital lobe
* meningismus - neck stiffness
* photophobia - sensitivity to light
* nausea with or without vomiting
* paresthesias - tingling, prickling, or numbing of skin
* hyperesthesia - severe sensitivity to touch
* bladder dysfunction with urinary retention
* vertigo
* blindness<ref name="urlwww.dhh.louisiana.gov"/>
* paralysis localized to one area
* general paralysis often ascending in nature starting with the feet and progressing upwards to involve the entire body.
* coma
* death
 
===Treatment===
 
The severity and clinical course of Angiostrongylus disease depends significantly on the ingested load of third stage larvae <ref>{{Cite pmid|    11498063}}</ref> creating great variability from case to case making it difficult to design clinical trials and to judge the effectiveness of treatments.  Typical conservative medical management including analgesics and sedatives provide minimal relief the headaches and hyperesthesias. Removing Cerebrospinal fluid at regular 3 to 7-day intervals is the only proven method of significantly reducing intracranial pressure and can be used for symptomatic treatment of headaches. This process may be repeated until improvement is shown.<ref name="urlwww.dhh.louisiana.gov"/>  Recent studies have shown that treatment with an antihelminthic such as mebendazole or albendazole combined with prednisone or prednisolone can reduce the severity and duration of headaches  but have not been shown to improve long term neurologic outcomes.
 
====Antimicrobial Regimen====
*'''1. Angiostrongylus cantonensis'''<ref>{{cite book | last = Gilbert | first = David | title = The Sanford guide to antimicrobial therapy | publisher = Antimicrobial Therapy | location = Sperryville, Va | year = 2015 | isbn = 978-1930808843 }}</ref>
:*Preferred: Symptomatic therapy, serial lumber puncture and analgesics
:*Alternative regimen: [[Albendazole]] 400 mg PO (once daily or bid) for 21 days
 
:*Preferred: Symptomatic therapy, serial lumber puncture, corticosteroids (prednisone 60mg qd for 2 weeks) and analgesics<ref>{{cite book | last = Gilbert | first = David | title = The Sanford guide to antimicrobial therapy | publisher = Antimicrobial Therapy | location = Sperryville, Va | year = 2015 | isbn = 978-1930808843 }}</ref>
:*Note: [[Albendazole]] and [[Mebendazole]] are generally not recommended due to the risk of exacerbation of neurological symptoms following anthelminthic therapy.<ref name="pmid19706911">{{cite journal| author=Chotmongkol V, Kittimongkolma S, Niwattayakul K, Intapan PM, Thavornpitak Y| title=Comparison of prednisolone plus albendazole with prednisolone alone for treatment of patients with eosinophilic meningitis. | journal=Am J Trop Med Hyg | year= 2009 | volume= 81 | issue= 3 | pages= 443-5 | pmid=19706911 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19706911  }} </ref>
 
===Diagnosis===
 
The diagnosis of disease caused by ''Angiostrongylus cantonensis'' infestation is often difficult and relies heavily on the history of a likely ingestion of a commonly infested host and the presence of typical features of the disease. The presumptive diagnosis is particularly strong when eospinophilic meningoencephalitis can be confirmed.  The diagnosis of Eosinophilic Meningitis can be arrived at through detection of elevated cranial pressure and increased numbers of eosinophils. The diagnosis of the cause of eosinophilic meningitis and the presence of ''A. cantonensis'' is remarkably more difficult. A spinal tap, or a sample of CSF, must be taken to search for ''A. cantonensis'' worms or larvae. ''A. cantonensis'' is undetectable in the CSF of more than half of the infected individuals. Current methods of detecting specific antigens associated with ''A. cantonensis'' are also unreliable. Consequently, alternative approaches to detect antigen-antibody reactions are being explored, such as Immuno-PCR.<ref name="urlImmuno-PCR for Detection of Antigen to Angiostrongylus cantonensis Circulating Fifth-Stage Worms -- Chye et al. 50 (1): 51 -- Clinical Chemistry">{{cite doi|10.1373/clinchem.2003.020867 }}</ref>
 
== References ==
 
{{Reflist|2}}
{{Reflist|2}}


== External links ==
== External links ==
{{commons category|Angiostrongylus cantonensis}}
*[http://www.cdc.gov/ncidod/dpd/parasites/angiostrongylus/factsht_angiostrongylus.htm Division of Parasitic Diseases], Centers for Disease Control and Prevention, ''Angiostrongylus cantonensis'' Infection
*[http://www.cdc.gov/ncidod/dpd/parasites/angiostrongylus/factsht_angiostrongylus.htm Division of Parasitic Diseases], Centers for Disease Control and Prevention, ''Angiostrongylus cantonensis'' Infection
**[http://www.dpd.cdc.gov/DPDx/HTML/Angiostrongyliasis.htm Laboratory Identification of Parasites of Public Health Concern], Parasites and Health, Angiostrongyliasis
**[http://www.dpd.cdc.gov/DPDx/HTML/Angiostrongyliasis.htm Laboratory Identification of Parasites of Public Health Concern], Parasites and Health, Angiostrongyliasis
Line 121: Line 91:
*[http://entnemdept.ufl.edu/creatures/nematode/rat_lungworm.htm ''Angiostronglyus cantonensis''] on the [[UF]] / [[Institute of Food and Agricultural Sciences|IFAS]] Featured Creatures website.
*[http://entnemdept.ufl.edu/creatures/nematode/rat_lungworm.htm ''Angiostronglyus cantonensis''] on the [[UF]] / [[Institute of Food and Agricultural Sciences|IFAS]] Featured Creatures website.


{{Helminthiases}}
[[Category:Parasitic diseases]]
 
[[Category:Infectious diseases]]
[[Category:Strongylida]]
[[Category:Parasitic nematodes]]
[[Category:Global health]]

Latest revision as of 16:01, 10 August 2015

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style="background:#Template:Taxobox colour;"|Template:Taxobox name
Adult female worm of Angiostrongylus cantonensis with characteristic barber-pole appearance (anterior end of worm is to the top). Scale bar is 1 mm.
Adult female worm of Angiostrongylus cantonensis with characteristic barber-pole appearance (anterior end of worm is to the top). Scale bar is 1 mm.
style="background:#Template:Taxobox colour;" | Scientific classification
Kingdom: Animalia
Phylum: Nematoda
Class: Secernentea
Order: Strongylida
Family: Metastrongylidae
Genus: Angiostrongylus
Species: A. cantonensis
Binomial name
Angiostrongylus cantonensis
(Chen, 1935)
This page is about microbiologic aspects of the organism(s).  For clinical aspects of the disease, see Angiostrongyliasis.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Angiostrongylus cantonensis is a parasitic nematode (roundworm) that causes Angiostrongyliasis, the most common cause of eosinophilic meningitis in Southeast Asia and the Pacific Basin. The nematode commonly resides in the pulmonary arteries of rats, giving it the nickname the rat lungworm. Snails are the primary intermediate hosts, where larvae develop until they are infective.

Humans are incidental hosts of this roundworm, and may become infected through ingestion of larvae in raw or undercooked snails or other vectors, or from contaminated water and vegetables. The larvae are then transported via the blood to the central nervous system (CNS), where they are the most common cause of eosinophilic meningitis, a serious condition that can lead to death or permanent brain and nerve damage. Identified in 1964, Angiostrongyliasis is an infection of increasing public health importance as globalization contributes to the geographic spread of the disease.

Infectious agent

Angiostrongylus cantonensis is a helminth of the phylum Nematoda, order Strongylida, and superfamily Metastrongyloidea. Nematodes are roundworms characterized by a tough outer cuticle, unsegmented bodies, and a fully developed gastrointestinal tract. The order Strongylida includes hookworms and lungworms. Metastrongyloidea are characterized as long, slender, threadlike worms that reside in the lungs of the definitive host.[1] Angiostrongylus costaricensis is a closely related worm that causes intestinal Angiostrongyliasis in Central and South America.

A. cantonensis is a nematode roundworm with 3 outer protective collagen layers, and a simple stomal opening or mouth with no lips or buccal cavity leading to a fully developed gastrointestinal tract. Males have a small copulatory bursa at the posterior. Females have a “barber pole” shape down the middle of the body, which is created by the twisting together of the intestine and uterine tubules. The worms are long and slender - males are 15.9-19 mm in length, and females are 21-25 mm in length.[2]

Life cycle

The adult form of A. cantonensis resides in the pulmonary arteries of rodents, where it reproduces. After the eggs hatch in the arteries, larvae migrate up the pharynx and are then swallowed again by the rodent and passed in the stool. These first stage larvae then penetrate or are swallowed by snail intermediate hosts, where they transform into second stage larvae and then into third stage infective larvae. Humans and rats acquire the infection when they ingest contaminated snails or paratenic (transport) hosts including prawns, crabs, and frogs, or raw vegetables containing material from these intermediate and paratenic hosts. After passing through the gastrointestinal tract, the worms enter circulation. In rats, the larvae then migrate to the meninges and develop for about a month before migrating to the pulmonary arteries, where they fully develop into adults.

Humans are incidental hosts; the larvae cannot reproduce in humans and therefore humans do not contribute to the A. cantonensis life cycle. In humans, the circulating larvae migrate to the meninges, but do not move on to the lungs. Sometimes the larvae will develop into the adult form in the brain and CSF, but they quickly die, inciting the inflammatory reaction that causes symptoms of infection.

Reservoirs

Rats are the definitive host and the main reservoir for A. cantonensis, though other small mammals may also become infected. While angiostrongylus can infect humans, humans do not act as reservoirs since the worm cannot reproduce in humans and therefore humans cannot contribute to their life cycle.

Vectors

A. cantonensis has many vectors, with the most common being several species of snails, including the giant African land snail (Achatina fulica) in the Pacific islands and snails of the genus Pila in Thailand and Malaysia. The golden apple snail, A. canaliculatus, is the most important vector in areas of China. Freshwater prawns, crabs, or other paratenic, or transport, hosts can also act as vectors.

Hosts

Intermediate hosts of larvae of for Angiostrongylus cantonensis include:

Definitive host of Angiostrongylus cantonensis include wild rodents, especially the brown rat (Rattus norvegicus)[3] and the black rat (Rattus rattus).[3]

Paratenic hosts of Angiostrongylus cantonensis include: predatory land flatworm Platydemus manokwari[5] and amphibians Bufo asiaticus,[5] Rana catesbeiana,[5] Rhacophorus leucomystax[5] and Rana limnocharis.[5]

In 2004, a captive Yellow-tailed Black Cockatoo (Calyptorhynchus funereus) and two free-living Tawny Frogmouths (Podargus strigoides) suffering neurological symptoms were shown to have the parasite. They were the first non-mammalian hosts discovered for the organism.

Transmission

Transmission of the parasite is usually from eating raw or undercooked snails or other vectors. Infection is also frequent from ingestion of contaminated water or unwashed salad that may contain small snail and slugs, or have been contaminated by them. Therefore it is very important to avoid raw snails, wash and cook vegetables thoroughly, and avoid open water sources that may be contaminated.

Incubation period

The incubation period in humans is usually from 1 week to 1 month after infection, and can be as long as 47 days. This interval varies, since humans are intermediate hosts and, the life cycle does not continue predictably as it would in a rat.

Eosinophilic meningitis

Although the clinical disease caused by Angiostrongylus invasion into the central nervous system is commonly referred to as "eosinophilic meningitis" the actual pathophysiology is of a meningoencephalitis with invasion not just of the meninges, or superficial lining of the brain, but also deeper brain tissue. Initial invasion through the lining of the brain, the meninges, may cause a typical inflammation of the meninges and a classic meningitis picture of headache, stiff neck and often fever. The parasites subsequently invade deeper into the brain tissue, causing specific localizing neurologic symptoms depending on where in the brain parenchyma they migrate. Neurologic findings and symptoms wax and wane as initial damage is done by the physical in-migration of the worms and secondary damage is done by the inflammatory response to the presence of dead and dying worms. This inflammation can lead in the short term to paralysis, bladder dysfunction, visual disturbance and coma and in the long term to permanent nerve damage, mental retardation, nerve damage, permanent brain damage or death.

Eosinophilic meningitis is commonly defined by the increased number of eosinophils in the cerebrospinal fluid (CSF). In most cases, Eosinophil levels rise to 10 or more eosinophils per μL in the cerebrospinal fluid, accounting for at least 10% of the total CSF leukocyte count. The chemical analysis of the CSF typically resembles the findings in "aseptic meningitis" with slightly elevated protein levels, normal glucose levels and negative bacterial cultures. Presence of a significantly decreased glucose on CSF analysis is an indicator of severe meningoencephalitis and may indicate a poor prognosis. Initial CSF analysis early in the disease process may occasionally show no increase of eosinophils only to have classical increases in eosinophils in subsequest spinal fluid analysis. Caution should be advised in using eosinophilic meningitis as the only criteria for diagnosing angiostrongylus infestation in someone with classic symptoms as the disease evolves with the migration of the worms into the central nervous system.

Eosinophils are specialized white blood cells of the granulocytic cell line which contain granules in their cytoplasm. These granules contain proteins that are toxic to parasites. When these granules degranulate, or break down, chemicals are released that combat parasites such as A. cantonensis. Eosinophils, which are located throughout the body, are guided to sites of inflammation by chemokines when the body is infested with parasites such as A. cantonensis. Once at the site of inflammation, Type 2 cytokines are released from helper T cells, which communicate with the Eosinophils, signaling them to activate. Once activated, eosinophils can begin the process of degranulation, releasing their toxic proteins in the fight against the foreign parasite.

References

  1. "Helminth Taxonomy - Phylum Nematoda", Schistosomiasis Research Group, accessed 26 February 2009.
  2. http://animaldiversity.ummz.umich.edu/site/accounts/information/Angiostrongylus_cantonensis.html, Accessed 2/26/09
  3. 3.0 3.1 3.2 Lindo J. F., Waugh C., Hall J., Cunningham-Myrie C., Ashley D., Eberhard M. L., Sullivan J. J., Bishop H. S., Robinson D. G., Holtz T. & Robinson R. D. (2002). "Enzootic Angiostrongylus cantonensis in Rats and Snails after an Outbreak of Human Eosinophilic Meningitis, Jamaica". Emerging Infectious Diseases 8(3): 324-326. HTM.
  4. 4.0 4.1 4.2 Template:Cite PMID
  5. 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 Asato R., Taira K., Nakamura M., Kudaka J., Itokazu K. & Kawanaka M. (2004) "Changing Epidemiology of Angiostrongyliasis Cantonensis in Okinawa Prefecture, Japan". Japanese Journal of Infectious Diseases 57: 184-186. article
  6. 6.0 6.1 6.2 6.3 (20 June 2001). "Land snail infection rates for the human parasitic nematode, Angiostrongylus cantonensis (rat lung worm) with notes on snail and parasite biology and distribution on Kadena AB, Okinawa Japan. Consultative Letter, IERA-DO-BR-CL-2001-0049." MEMORANDUM FOR 18 MDG/SGPM, Department of the Air Force, 11 pp. PDF.
  7. Template:Cite doi.
  8. PMID 14558868 (PMID 14558868)
    Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
  9. 9.0 9.1 9.2 9.3 Högger C. H. (update 25 March 2003). "Antagonists of Slugs and Snails. A Bibliography of Sources and a List of Citations grouped according to Taxon of the Antagonists". in web Archive.

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