Acute monocytic leukemia pathophysiology: Difference between revisions
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M5 is associated with characteristic chromosomal abnormalities, often involving 11q23 or t(9;11)affecting the MLL locus, however the MLL translocation is also found in other AML subtypes. MLL is believed to be prognostically unfavorable in AML-M5 compared to other genetic alterations involving MLL such as t(9;11) The t(8;16) translocation in MLL is associated with hemophagocytosis. | M5 is associated with characteristic chromosomal abnormalities, often involving 11q23 or t(9;11)affecting the MLL locus, however the MLL translocation is also found in other AML subtypes. MLL is believed to be prognostically unfavorable in AML-M5 compared to other genetic alterations involving MLL such as t(9;11) The t(8;16) translocation in MLL is associated with hemophagocytosis. | ||
===Immunology=== | ===Immunology=== | ||
Immunophenotypically, M5-AML variably express myeloid ([[CD13]], [[CD33]]) and monocytic ([[CD11b]], [[CD11c]]) markers. Cells may aberrantly express B | Immunophenotypically, M5-AML variably express myeloid ([[CD13]], [[CD33]]) and monocytic ([[CD11b]], [[CD11c]]) markers. Cells may aberrantly express B cells marker [[CD20]] and the NK marker [[CD56]]. Monoblasts may be positive for [[CD34]]. | ||
==Risk Factors== | ==Risk Factors== | ||
Latest revision as of 15:04, 14 August 2015
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Acute monocytic leukemia Microchapters |
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Differentiating Acute monocytic leukemia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Genetics
M5 is associated with characteristic chromosomal abnormalities, often involving 11q23 or t(9;11)affecting the MLL locus, however the MLL translocation is also found in other AML subtypes. MLL is believed to be prognostically unfavorable in AML-M5 compared to other genetic alterations involving MLL such as t(9;11) The t(8;16) translocation in MLL is associated with hemophagocytosis.
Immunology
Immunophenotypically, M5-AML variably express myeloid (CD13, CD33) and monocytic (CD11b, CD11c) markers. Cells may aberrantly express B cells marker CD20 and the NK marker CD56. Monoblasts may be positive for CD34.
Risk Factors
AML-M5 is thought to be associated with exposure to epidophyllotoxins.