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{{Langerhans cell histiocytosis}}
{{Langerhans cell histiocytosis}}
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{{CMG}} {{AE}} {{HL}}
 
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==Overview==
==Overview==
Features can be non-specific from generalized inflammatory response e.g fever, lethargy, weight loss or can be due to specific organ involvement.
Common symptoms of Langerhans cell histiocytosis include [[bone]] pain, [[rash]], [[fever]], and [[failure to thrive]].<ref name="wiki">Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016</ref><ref name="radio"> Langerhans cell histiocytosis. Radiopeadia (2015) http://radiopaedia.org/articles/langerhans-cell-histiocytosis Accessed on February, 3 2016</ref><ref name="PDQ">Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version.  National Cancer Institute (2015) http://www.cancer.gov/types/langerhans/hp/langerhans-treatment-pdq Accessed on February, 3 2016</ref>
 
==History==
==History and Symptoms==
* When evaluating a patient for Langerhans cell histiocytosis, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below:<ref name="PDQ">Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version.  National Cancer Institute (2015) http://www.cancer.gov/types/langerhans/hp/langerhans-treatment-pdq Accessed on February, 3 2016</ref>
*Histiocytosis X often affects the whole body. A disease that affects the whole body is called a systemic disorder.
** Review family history for members with positive history of the disease
 
** Growth velocity chart
*Symptoms can vary between children and adults, although there can be some overlap. Tumors in weight-bearing bones, such as the legs or spine, may cause the bones to fracture without apparent reason.
** Any history of excessive thirst and urination
 
==Symptoms==
*Symptoms in children may include:
* '''Common symptoms of Langerhans cell histiocytosis among children include:'''<ref name="wiki">Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016</ref><ref name="radio"> Langerhans cell histiocytosis. Radiopeadia (2015) http://radiopaedia.org/articles/langerhans-cell-histiocytosis Accessed on February, 3 2016</ref><ref name="PDQ">Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version. National Cancer Institute (2015) http://www.cancer.gov/types/langerhans/hp/langerhans-treatment-pdq Accessed on February, 3 2016</ref>
:*[[Abdominal pain]]
:*[[Abdominal pain]]
:*[[Bone pain]] (possibly)
:*[[Bone pain]]  
:*[[Delayed puberty]]
:*[[Delayed puberty]]
:*[[Dizziness]]
:*[[Dizziness]]
:*Ear drainage that continues long-term
:*Eyes that appear to stick out (protrude) more and more
:*Irritability
:*Irritability
:*[[Failure to thrive]]
:*[[Failure to thrive]]
:*[[Fever]]
:*[[Fever]]
:*Frequent urination
:*[[Polyurea]]
:*[[Headache]]
:*[[Headache]]
:*[[Jaundice]]
:*Limping
:*Limping
:*Mental deterioration
:*Mental deterioration
:*[[Rash]] ([[petechiae]] or [[purpura]])
:*[[Rash]]  
:*[[Seborrheic dermatitis]] of the scalp
:*[[Seizures]]
:*[[Seizures]]
:*[[Short stature]]
:*[[Short stature]]
:*Swollen lymph glands
:*Thirst
:*Thirst
:*[[Vomiting]]
:*[[Vomiting]]
:*[[Weight loss]]
:*[[Weight loss]]
 
* '''Common symptoms of Langerhans cell histiocytosis among adults include:''' <ref>{{Cite journal
''Note: Children over 5 years old often have only bone involvement.''
| author = [[Elena Gkrouzman]], [[Rene H. Cuadra]] & [[Jason Jacob]]
 
| title = Langerhans Cell Histiocytosis of the Bone Presenting as Back Pain: An Unusual Diagnosis for a Common Complaint
*Symptoms in adults may include:
| journal = [[Connecticut medicine]]
| volume = 79
| issue = 7
| pages = 409–414
| year = 2015
| month = August
| pmid = 26411178
}}</ref><ref>{{Cite journal
| author = [[Hiroyuki Tsuchie]], [[Kyoji Okada]], [[Hiroyuki Nagasawa]], [[Michihiro Yano]], [[Hiroshi Nanjyo]] & [[Yoichi Shimada]]
| title = Langerhans cell histiocytosis of the sternum
| journal = [[Upsala journal of medical sciences]]
| volume = 114
| issue = 2
| pages = 121–125
| year = 2009
| month =
| doi = 10.1080/03009730802642360
| pmid = 19396700
}}</ref><ref>{{Cite journal
| author = [[Koray Aydogdu]], [[Ersin Gunay]], [[Gokturk Findik]], [[Sibel Gunay]], [[Yetkin Agackiran]], [[Sadi Kaya]], [[Nurettin Karaoglanoglu]] & [[Irfan Tastepe]]
| title = Pulmonary Langerhans cell histiocytosis; characteristics of 11 cases
| journal = [[Tuberkuloz ve toraks]]
| volume = 61
| issue = 4
| pages = 333–341
| year = 2013
| month =
| pmid = 24506750
}}</ref><ref>{{Cite journal
| author = [[A. Artigues Barcelo]], [[P. Guiscafre Fontirroig]], [[P. de Miguel Sebastian]], [[R. M. Salgado]] & [[M. T. Albiol Varella]]
| title = &#91;Fever and hyperprolactinaemia as the onset of Langerhans cell histiocytosis&#93;
| journal = [[Anales de medicina interna (Madrid, Spain : 1984)]]
| volume = 22
| issue = 11
| pages = 535–537
| year = 2005
| month = November
| pmid = 16454588
}}</ref>
:*[[Bone pain]]
:*[[Bone pain]]
:*[[Chest pain]]
:*[[Chest pain]]
:*[[Cough]]
:*[[Cough]]
:*[[Fever]]
:*[[Fever]]
:*General discomfort, uneasiness, or ill feeling (malaise)
:*[[Malaise]]
:*Increased amount of urine
:*[[Polyurea]]
:*[[Rash]]
:*[[Rash]]
:*[[Shortness of breath]]
:*[[Shortness of breath]]
:*Thirst and increased drinking of fluids
:*[[Polydipsia]]
:*[[Weight loss]]
:*[[Weight loss]]


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Latest revision as of 00:01, 26 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Common symptoms of Langerhans cell histiocytosis include bone pain, rash, fever, and failure to thrive.[1][2][3]

History

  • When evaluating a patient for Langerhans cell histiocytosis, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below:[3]
    • Review family history for members with positive history of the disease
    • Growth velocity chart
    • Any history of excessive thirst and urination

Symptoms

  • Common symptoms of Langerhans cell histiocytosis among children include:[1][2][3]
  • Common symptoms of Langerhans cell histiocytosis among adults include: [4][5][6][7]

References

  1. ↑ 1.0 1.1 Langerhans cell histiocytosis. Wikipedia (2015) https://en.wikipedia.org/wiki/Langerhans_cell_histiocytosis Accessed on February, 2 2016
  2. ↑ 2.0 2.1 Langerhans cell histiocytosis. Radiopeadia (2015) http://radiopaedia.org/articles/langerhans-cell-histiocytosis Accessed on February, 3 2016
  3. ↑ 3.0 3.1 3.2 Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version. National Cancer Institute (2015) http://www.cancer.gov/types/langerhans/hp/langerhans-treatment-pdq Accessed on February, 3 2016
  4. ↑ Elena Gkrouzman, Rene H. Cuadra & Jason Jacob (2015). "Langerhans Cell Histiocytosis of the Bone Presenting as Back Pain: An Unusual Diagnosis for a Common Complaint". Connecticut medicine. 79 (7): 409–414. PMID 26411178. Unknown parameter |month= ignored (help)
  5. ↑ Hiroyuki Tsuchie, Kyoji Okada, Hiroyuki Nagasawa, Michihiro Yano, Hiroshi Nanjyo & Yoichi Shimada (2009). "Langerhans cell histiocytosis of the sternum". Upsala journal of medical sciences. 114 (2): 121–125. doi:10.1080/03009730802642360. PMID 19396700.
  6. ↑ Koray Aydogdu, Ersin Gunay, Gokturk Findik, Sibel Gunay, Yetkin Agackiran, Sadi Kaya, Nurettin Karaoglanoglu & Irfan Tastepe (2013). "Pulmonary Langerhans cell histiocytosis; characteristics of 11 cases". Tuberkuloz ve toraks. 61 (4): 333–341. PMID 24506750.
  7. ↑ A. Artigues Barcelo, P. Guiscafre Fontirroig, P. de Miguel Sebastian, R. M. Salgado & M. T. Albiol Varella (2005). "[Fever and hyperprolactinaemia as the onset of Langerhans cell histiocytosis]". Anales de medicina interna (Madrid, Spain : 1984). 22 (11): 535–537. PMID 16454588. Unknown parameter |month= ignored (help)


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