Linitis plastica causes: Difference between revisions
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{{Linitis plastica}} | {{Linitis plastica}} | ||
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==Overview== | |||
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in [[CDH1 (gene)|CDH1]] gene. [[CDH1 (gene)|CDH1]] gene codes for [[Cadherin|E-cadherin]] adhesion protein. Secondarily, linitis plastica may be caused by [[metastasis]] to the [[stomach]] or by the [[Lye|ingestion of lye]]. | |||
==Causes== | |||
===Primary Causes=== | |||
*Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.<ref name="pmid14630673">{{cite journal |vauthors=Graziano F, Humar B, Guilford P |title=The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice |journal=Ann. Oncol. |volume=14 |issue=12 |pages=1705–13 |year=2003 |pmid=14630673 |doi= |url=}}</ref> | |||
* [[Somatic]] [[mutations]] in the ''CDH1'' [[gene]] can occur by: | |||
**Hypermethylation | |||
**[[Loss of heterozygosity]] | |||
**Silencing mutations | |||
===Secondary causes=== | |||
*[[Lye]] ingestion | |||
*[[Metastasis|Metastatic]] infiltration of the stomach by: | |||
**[[Lung cancer]] | |||
**[[Breast cancer]] | |||
**[[Non-Hodgkin lymphoma]]<ref name="pmid8888226">{{cite journal |vauthors=Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC |title=Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica |journal=Radiology |volume=201 |issue=2 |pages=375–8 |year=1996 |pmid=8888226 |doi=10.1148/radiology.201.2.8888226 |url=}}</ref> | |||
==References== | ==References== | ||
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[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
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Latest revision as of 17:07, 8 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by metastasis to the stomach or by the ingestion of lye.
Causes
Primary Causes
- Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.[1]
- Somatic mutations in the CDH1 gene can occur by:
- Hypermethylation
- Loss of heterozygosity
- Silencing mutations
Secondary causes
- Lye ingestion
- Metastatic infiltration of the stomach by:
References
- ↑ Graziano F, Humar B, Guilford P (2003). "The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice". Ann. Oncol. 14 (12): 1705–13. PMID 14630673.
- ↑ Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC (1996). "Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica". Radiology. 201 (2): 375–8. doi:10.1148/radiology.201.2.8888226. PMID 8888226.