|
|
| (30 intermediate revisions by the same user not shown) |
| Line 19: |
Line 19: |
|
| |
|
|
| |
|
| ==Laboratory Findings==
| |
| The diagnosis is easily established on histological grounds, but immunophenotyping is encouraged to distinguish follicular lymphoma from a nodular MCL or SLL.
| |
| *Diagnosis is established by immunophenotyping using IHC and/or flow cytometry for cell surface marker analysis.
| |
| *Follicular lymphoma has a characteristic immunophenotype, which includes CD20+, CD10+, BCL2+, CD23+/-, CD43-, CD5-, CCND1- and BCL6+. Occasional cases of FL may be CD10- or BCL2-.*In patients with BCL2-negative localized disease, the diagnosis of pediatric-type follicular lymphoma may be considered.
| |
| *Low-grade follicular lymphoma with a high proliferation index (as determined by Ki-67 immunostaining) has been shown to be associated with an aggressive clinical behavior.
| |
| :*There is no evidence, however, that high Ki-67 should guide the selection of therapy.
| |
| :*Molecular genetic analysis to detect BCL2 rearrangement, cytogenetics or FISH to identify t(14;18), and immunohistochemistry for Ki-67 may be useful under certain circumstances.
| |
|
| |
|
| ===Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Neoplasms=== | | ===Use of Immunophenotyping/Genetic Testing in Differential Diagnosis of Mature B-Cell and NK/T-Cell Neoplasms=== |
| Line 45: |
Line 38: |
| {{Familytree/end}} | | {{Familytree/end}} |
| </div> | | </div> |
|
| |
| ===Classification of large cells based on Immunophenotypic/Genetic testing <ref>{{cite web | title = Non-Hodgkin's Lymphomas (NCCN.org) | url = http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf }}</ref>===
| |
| *Diffuse large B-cell lymphoma (DLBCL),NOS
| |
| :*T-cell/histocyte-rich large B-cell lymphoma (THRLBCL)
| |
| :*Primary DLBCL of the CNS
| |
| :*Primary cutaneous DLBCL, leg type
| |
| :*EBV-positive DLBCL of the elderly (EBV + DLBCL)
| |
| *DLBCL associated with chronic inflammation
| |
| *Lymphoid granulomatosis
| |
| *Primary mediastinal (thymic) large B-cell Lymphoma (PMBL)
| |
| *Intravascular large B-cell lymphoma
| |
| *ALK-positive large B-cell lymphoma
| |
| *Plasmablastic lymphoma
| |
| *Large B-cell lymphoma arising in HHV8-assciated multicentric Castleman disease (LBCL in HHV8 + MCD)
| |
| *Primary effusion lymphoma
| |
| *B-cell lymphoma unclassifiable, intermediate between DLBCL(U-DLBCL) and classical Hodgkins lymphoma(CHL)
| |
| *Mantle cell Lymphoma(MCL),pleomorphic variant
| |