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__NOTOC__ | __NOTOC__ | ||
{{Wilms' tumor}} | {{Wilms' tumor}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{SSW}},{{SC}} | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of wilms tumor include familial wilms tumor, [[congenital anomalies]], [[WT1|WT-1]] related syndromes and WT2-related [[Syndrome|syndromes]]. Less common risk factors in the development of wilms tumor include perlman syndrome, simpson-golabi-ehemel syndrome, [[Sotos syndrome]], 9q22.3 microdeletion syndrome, [[Bloom syndrome]], li-fraumeni syndrome and [[Alagille syndrome]]. | |||
==Risk factors== | == Risk factors == | ||
=== Common Risk Factors === | |||
* Common risk factors in the development of wilms tumor include: | |||
** Familial Wilms tumor <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq </ref> | |||
** Congenital anomaly | |||
*** Hemihyperplasia | |||
*** Urinary tract anomalies, including [[cryptorchidism]] and [[hypospadias]] | |||
*** [[Aniridia]] | |||
** WT1-related syndromes include the following:<ref name="cancergov2">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq</ref> | |||
*** [[WAGR syndrome|WAGR]] syndrome | |||
*** [[Denys-Drash syndrome]] and [[Frasier syndrome]] | |||
** WT2-related syndromes include the following: | |||
*** [[Beckwith-Wiedemann syndrome]]<ref name="pmid9441738">{{cite journal |vauthors=Crider-Miller SJ, Reid LH, Higgins MJ, Nowak NJ, Shows TB, Futreal PA, Weissman BE |title=Novel transcribed sequences within the BWS/WT2 region in 11p15.5: tissue-specific expression correlates with cancer type |journal=Genomics |volume=46 |issue=3 |pages=355–63 |date=December 1997 |pmid=9441738 |doi=10.1006/geno.1997.5061 |url=}}</ref> | |||
=== Less Common Risk Factors === | |||
*Less common risk factors in the development of wilms tumor include: | |||
** Other syndromes include the following: | |||
*** Perlman syndrome<ref name="pmid23613427">{{cite journal |vauthors=Morris MR, Astuti D, Maher ER |title=Perlman syndrome: overgrowth, Wilms tumor predisposition and DIS3L2 |journal=Am J Med Genet C Semin Med Genet |volume=163C |issue=2 |pages=106–13 |date=May 2013 |pmid=23613427 |doi=10.1002/ajmg.c.31358 |url=}}</ref> | |||
*** Simpson-Golabi-Behemel syndrome<ref name="pmid1219">{{cite journal |vauthors=Alton KB, Patrick JE, Shaw C, McGuire JL |title=Comparative biotransformation of triflubazam in rats, dogs, and monkeys |journal=Drug Metab. Dispos. |volume=3 |issue=6 |pages=445–52 |date=1975 |pmid=1219 |doi= |url=}}</ref> | |||
*** [[Sotos syndrome]]<ref name="pmid1479">{{cite journal |vauthors=Heller BR, Walsh FJ |title=Changing nursing students' attitudes toward the aged: an experimental study |journal=J Nurs Educ |volume=15 |issue=1 |pages=9–17 |date=January 1976 |pmid=1479 |doi= |url=}}</ref> | |||
*** 9q22.3 microdeletion syndrome | |||
*** [[Bloom syndrome]]<ref name="pmid8998536">{{cite journal |vauthors=Berger C, Frappaz D, Leroux D, Blez F, Vercherat M, Bouffet E, Jalbert P, Brunat-Mentigny M |title=[Wilms tumor and Bloom syndrome] |language=French |journal=Arch Pediatr |volume=3 |issue=8 |pages=802–5 |date=August 1996 |pmid=8998536 |doi= |url=}}</ref> | |||
*** Li-Fraumeni syndrome<ref name="pmid83924352">{{cite journal |vauthors=Hartley AL, Birch JM, Tricker K, Wallace SA, Kelsey AM, Harris M, Jones PH |title=Wilms' tumor in the Li-Fraumeni cancer family syndrome |journal=Cancer Genet. Cytogenet. |volume=67 |issue=2 |pages=133–5 |date=June 1993 |pmid=8392435 |doi= |url=}}</ref> | |||
*** [[Alagille syndrome]]<ref name="pmid17584876">{{cite journal |vauthors=Bourdeaut F, Guiochon-Mantel A, Fabre M, Martelli H, Patte C, Porta G, Bernard O, Delattre O, Jacquemin E |title=Alagille syndrome and nephroblastoma: Unusual coincidence of two rare disorders |journal=Pediatr Blood Cancer |volume=50 |issue=4 |pages=908–11 |date=April 2008 |pmid=17584876 |doi=10.1002/pbc.21255 |url=}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Kidney diseases]] | |||
[[Category:Types of cancer]] | |||
[[Category:Urology]] | |||
[[Category:Pediatrics]] | |||
[[Category:Hematology]] | |||
Latest revision as of 21:26, 11 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2],Shanshan Cen, M.D. [3]
Overview
Common risk factors in the development of wilms tumor include familial wilms tumor, congenital anomalies, WT-1 related syndromes and WT2-related syndromes. Less common risk factors in the development of wilms tumor include perlman syndrome, simpson-golabi-ehemel syndrome, Sotos syndrome, 9q22.3 microdeletion syndrome, Bloom syndrome, li-fraumeni syndrome and Alagille syndrome.
Risk factors
Common Risk Factors
- Common risk factors in the development of wilms tumor include:
- Familial Wilms tumor [1]
- Congenital anomaly
- Hemihyperplasia
- Urinary tract anomalies, including cryptorchidism and hypospadias
- Aniridia
- WT1-related syndromes include the following:[2]
- WAGR syndrome
- Denys-Drash syndrome and Frasier syndrome
- WT2-related syndromes include the following:
Less Common Risk Factors
- Less common risk factors in the development of wilms tumor include:
- Other syndromes include the following:
- Perlman syndrome[4]
- Simpson-Golabi-Behemel syndrome[5]
- Sotos syndrome[6]
- 9q22.3 microdeletion syndrome
- Bloom syndrome[7]
- Li-Fraumeni syndrome[8]
- Alagille syndrome[9]
- Other syndromes include the following:
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
- ↑ Crider-Miller SJ, Reid LH, Higgins MJ, Nowak NJ, Shows TB, Futreal PA, Weissman BE (December 1997). "Novel transcribed sequences within the BWS/WT2 region in 11p15.5: tissue-specific expression correlates with cancer type". Genomics. 46 (3): 355–63. doi:10.1006/geno.1997.5061. PMID 9441738.
- ↑ Morris MR, Astuti D, Maher ER (May 2013). "Perlman syndrome: overgrowth, Wilms tumor predisposition and DIS3L2". Am J Med Genet C Semin Med Genet. 163C (2): 106–13. doi:10.1002/ajmg.c.31358. PMID 23613427.
- ↑ Alton KB, Patrick JE, Shaw C, McGuire JL (1975). "Comparative biotransformation of triflubazam in rats, dogs, and monkeys". Drug Metab. Dispos. 3 (6): 445–52. PMID 1219.
- ↑ Heller BR, Walsh FJ (January 1976). "Changing nursing students' attitudes toward the aged: an experimental study". J Nurs Educ. 15 (1): 9–17. PMID 1479.
- ↑ Berger C, Frappaz D, Leroux D, Blez F, Vercherat M, Bouffet E, Jalbert P, Brunat-Mentigny M (August 1996). "[Wilms tumor and Bloom syndrome]". Arch Pediatr (in French). 3 (8): 802–5. PMID 8998536.
- ↑ Hartley AL, Birch JM, Tricker K, Wallace SA, Kelsey AM, Harris M, Jones PH (June 1993). "Wilms' tumor in the Li-Fraumeni cancer family syndrome". Cancer Genet. Cytogenet. 67 (2): 133–5. PMID 8392435.
- ↑ Bourdeaut F, Guiochon-Mantel A, Fabre M, Martelli H, Patte C, Porta G, Bernard O, Delattre O, Jacquemin E (April 2008). "Alagille syndrome and nephroblastoma: Unusual coincidence of two rare disorders". Pediatr Blood Cancer. 50 (4): 908–11. doi:10.1002/pbc.21255. PMID 17584876.