Urethral cancer classification: Difference between revisions

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==Overview==
==Overview==
Urethral cancer may be classified according to cell types into 3 subtypes: [[transitional cell carcinoma]], [[squamous cell carcinoma]], and [[adenocarcinoma]]. It may also be classified into distal urethral cancer, proximal urethral cancer and urethral cancer associated with invasive [[bladder cancer]].
[[Urethral cancer|Urethra]]<nowiki/>l [[cancer]] may be classified based on histology into 3 sub types which include [[transitional cell carcinoma]], [[squamous cell carcinoma]], and [[adenocarcinoma]]. It may also be classified based on anatomical location of cancer into [[distal]] [[urethral]] [[cancer]], [[proximal]] [[Urethral cancer|urethral]] [[cancer]].


==Classification==
==Classification==
===Based on histology===
===Based on histology===
In an analysis of Surveillance, Epidemiology, and End Results data from 1973 to 2002, the most common histologic types of urethral cancer were:
Urethral cancer can be classified based on histology into:


* [[Transitional cell]] (55%)
* [[Transitional cell]] (55%)
* [[Squamous cell]] (21.5%)
* [[Squamous cell]] (21.5%)
* [[Adenocarcinoma]] (16.4%)
* [[Adenocarcinoma]] (16.4%)
* Melanoma


Other cell types, such as [[melanoma]], were extremely rare.
===Based on anatomical location===
Urethral cancer can also be classified based on anatomical location into:
* '''Distal Urethral Cancer:''' <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq </ref>
** Female: Distal third of the [[urethra]]
** Males: Anterior, or penile portion of the [[urethra]]
* '''Proximal Urethral Cancer:'''
** Females: Not limited to distal third
** [[Male]]: Bulbomembranous and [[prostatic]] [[urethra]]
{| class="wikitable"
!Distal
!Proximal
|-
|
* Superficial lesions
* Distal third of the [[urethra]] in females
* In males:
** Anterior, or penile portion of the [[urethra]]
|
* Deeply invasive.


===Based on location===
* Not limited to distal third in females.
'''Distal Urethral Cancer''' <ref name="cancergov"> National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq </ref>
* [[Male]]: Bulbomembranous and [[prostatic]] [[urethra]]
 
|}
These lesions are often superficial.
 
* Female: Lesions of the distal third of the urethra.
* Male: Anterior, or penile, portion of the urethra, including the meatus and pendulous urethra.
 
'''Proximal Urethral Cancer'''
 
These lesions are often deeply invasive.
 
* Female: Lesions not clearly limited to the distal third of the urethra.
* Male: Bulbomembranous and prostatic urethra.
 
'''Urethral Cancer Associated with Invasive Bladder Cancer'''
 
Approximately 5% to 10% of men with [[cystectomy]] for bladder cancer may have or may develop urethral cancer distal to the urogenital diaphragm.


==References==
==References==
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[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category:Urologic Surgery]]
[[Category:Urologic Surgery]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Urology]]
[[Category:Nephrology]]
[[Category:Surgery]]

Latest revision as of 14:44, 3 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Urethral cancer may be classified based on histology into 3 sub types which include transitional cell carcinoma, squamous cell carcinoma, and adenocarcinoma. It may also be classified based on anatomical location of cancer into distal urethral cancer, proximal urethral cancer.

Classification

Based on histology

Urethral cancer can be classified based on histology into:

Based on anatomical location

Urethral cancer can also be classified based on anatomical location into:

  • Distal Urethral Cancer: [1]
    • Female: Distal third of the urethra
    • Males: Anterior, or penile portion of the urethra
  • Proximal Urethral Cancer:
Distal Proximal
  • Superficial lesions
  • Distal third of the urethra in females
  • In males:
    • Anterior, or penile portion of the urethra
  • Deeply invasive.

References

  1. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq