Glioma medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Treatment for | Treatment for glioma depends on the location and grade. The predominant therapy for glioma is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[radiation]] may be required.<ref name=ddd>Treatment of glioma. SurgWiki.com. http://www.surgwiki.com/wiki/Intracranial_tumours,_infection_and_aneurysms#Astrocytoma</ref> | ||
==Medical Therapy== | ==Medical Therapy== | ||
The predominant therapy for glioma is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[radiation]] may be required.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | Treatment for glioma depends on the location and grade. The predominant therapy for glioma is [[surgical resection]]. Adjunctive [[chemotherapy]] and [[radiation]] may be required.<ref name=ddd>Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref> | ||
===Radiotherapy=== | ===Radiotherapy=== | ||
* | *Post-operative [[radiation therapy]] is often used as an adjunct to [[surgery]] in the treatment of high-grade gliomas as it has shown to double the median survival for high-grade gliomas to 37 weeks (versus 17 weeks with surgery alone). | ||
*Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence. | *Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence. | ||
*Targeted three-dimensional conformal [[radiotherapy]] is preferred to whole brain radiotherapy. | *Targeted three-dimensional conformal [[radiotherapy]] is preferred to whole brain radiotherapy. | ||
===Chemotherapy=== | ===Chemotherapy=== | ||
*[[Chemotherapy]] is indicated as adjuvant therapy for glioma. | *[[Chemotherapy]] is indicated as adjuvant therapy for glioma. | ||
*[[Temozolomide]] ([[Temodar]]) is the preferred drug for the treatment of glioma as it easily penetrates the blood brain barrier. | *[[Temozolomide]] ([[Temodar]]) is the preferred drug for the treatment of high-grade and recurring low-grade glioma, as it easily penetrates the blood brain barrier. | ||
*Other chemotherapeutic drugs that may be used for the treatment of | *Other chemotherapeutic drugs that may be used for the treatment of glioma include: | ||
**[[Carmustine]] | **[[Carmustine]] | ||
**[[Lomustine]] | **[[Lomustine]] | ||
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Latest revision as of 23:38, 26 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Sujit Routray, M.D. [3]
Overview
Treatment for glioma depends on the location and grade. The predominant therapy for glioma is surgical resection. Adjunctive chemotherapy and radiation may be required.[1]
Medical Therapy
Treatment for glioma depends on the location and grade. The predominant therapy for glioma is surgical resection. Adjunctive chemotherapy and radiation may be required.[1]
Radiotherapy
- Post-operative radiation therapy is often used as an adjunct to surgery in the treatment of high-grade gliomas as it has shown to double the median survival for high-grade gliomas to 37 weeks (versus 17 weeks with surgery alone).
- Radiotherapy may not cure the cancer, but can control the tumor and delay recurrence.
- Targeted three-dimensional conformal radiotherapy is preferred to whole brain radiotherapy.
Chemotherapy
- Chemotherapy is indicated as adjuvant therapy for glioma.
- Temozolomide (Temodar) is the preferred drug for the treatment of high-grade and recurring low-grade glioma, as it easily penetrates the blood brain barrier.
- Other chemotherapeutic drugs that may be used for the treatment of glioma include:
References
- ↑ 1.0 1.1 Treatment of glioma. SurgWiki.com. http://www.surgwiki.com/wiki/Intracranial_tumours,_infection_and_aneurysms#Astrocytoma