Tumor lysis syndrome laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Tumor lysis syndrome}} | {{Tumor lysis syndrome}} | ||
{{CMG}} {{AE}} {{MJK}} | {{CMG}} {{shyam}} {{AE}} {{MJK}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum [[uric acid]], [[potassium]], [[phosphorus]], and low [[calcium]].<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum [[uric acid]], [[potassium]], [[phosphorus]], and [[lactate dehydrogenase]]. Another laboratory abnormality is low [[calcium]].<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref><ref name="pmid18509186">{{cite journal| author=Coiffier B, Altman A, Pui CH, Younes A, Cairo MS| title=Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. | journal=J Clin Oncol | year= 2008 | volume= 26 | issue= 16 | pages= 2767-78 | pmid=18509186 | doi=10.1200/JCO.2007.15.0177 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18509186 }} </ref> | ||
*Blood: | *Blood: | ||
:*[[Hyperuricemia]] ≥ 476 μmol/l | :*[[Hyperuricemia]] ≥ 476 μmol/l | ||
| Line 12: | Line 12: | ||
:*[[Hyperkalemia]] ≥ 6·0 mmol/l | :*[[Hyperkalemia]] ≥ 6·0 mmol/l | ||
:*[[Hypocalcemia]] ≤ 1·75 mmol/l | :*[[Hypocalcemia]] ≤ 1·75 mmol/l | ||
:*[[Creatinine]] ≥1.5 x ULN | |||
:*[[Lactate dehydrogenase]] > ULN | |||
:*Metabolic acidosis | |||
*[[Urinalysis]]: | *[[Urinalysis]]: | ||
:*Low urine output | :*Low urine output | ||
| Line 26: | Line 29: | ||
[[Category:Blood]] | [[Category:Blood]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
Latest revision as of 03:19, 21 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [3]
Overview
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum uric acid, potassium, phosphorus, and lactate dehydrogenase. Another laboratory abnormality is low calcium.[1]
Laboratory Findings
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:[1][2]
- Blood:
- Hyperuricemia ≥ 476 μmol/l
- Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults)
- Hyperkalemia ≥ 6·0 mmol/l
- Hypocalcemia ≤ 1·75 mmol/l
- Creatinine ≥1.5 x ULN
- Lactate dehydrogenase > ULN
- Metabolic acidosis
- Low urine output
- Uric acid crystals or amorphous urates
- High uric acid-creatinine ratio > 1.0
References
- ↑ 1.0 1.1 Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.
- ↑ Coiffier B, Altman A, Pui CH, Younes A, Cairo MS (2008). "Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review". J Clin Oncol. 26 (16): 2767–78. doi:10.1200/JCO.2007.15.0177. PMID 18509186.