Medulloblastoma epidemiology and demographics: Difference between revisions
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{{Medulloblastoma}} | {{Medulloblastoma}} | ||
{{CMG}} {{AE}}{{HL}} | {{CMG}} {{AE}}{{HL}}{{sali}} | ||
==Overview== | ==Overview== | ||
Medulloblastoma is the second most common brain tumor among the pediatric population.<ref name="wiki">Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015</ref> The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828 }} </ref> The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.<ref name="pmid23245832">{{cite journal| author=Bartlett F, Kortmann R, Saran F| title=Medulloblastoma. | journal=Clin Oncol (R Coll Radiol) | year= 2013 | volume= 25 | issue= 1 | pages= 36-45 | pmid=23245832 | doi=10.1016/j.clon.2012.09.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23245832 }} </ref> Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828 }} </ref> | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
=== | ===Prevalence=== | ||
* Medulloblastoma is the second most common brain tumor among the [[pediatric]] population.<ref name="wiki">Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015</ref> | |||
* Medulloblastoma is considered a rare [[tumor]] among adults, as it comprises fewer than 2% of all brain tumors among that age group. | |||
===Incidence=== | ===Incidence=== | ||
* The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828 }} </ref> | |||
===Age=== | ===Age=== | ||
* The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.<ref name="pmid23245832">{{cite journal| author=Bartlett F, Kortmann R, Saran F| title=Medulloblastoma. | journal=Clin Oncol (R Coll Radiol) | year= 2013 | volume= 25 | issue= 1 | pages= 36-45 | pmid=23245832 | doi=10.1016/j.clon.2012.09.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23245832 }} </ref> | |||
* The [[molecular]] subgroup of medulloblastoma has an influence on the age of presentation such as:<ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref> | |||
:* WNT medulloblastoma subgroup presents among older children | |||
:* SHH medulloblastoma subgroup presents among infants and adults | |||
:* Group 3 medulloblastoma presents among younger children | |||
:* Group 4 medulloblastoma presents among younger children | |||
===Gender=== | ===Gender=== | ||
* The overall age adjusted incidence rate of medulloblastoma among males is approximately 0.84 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828 }} </ref> | |||
* The overall age adjusted incidence rate of medulloblastoma among females is approximately 0.58 per 100,000 individuals in the United States. | |||
* Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1. | |||
===Race=== | ===Race=== | ||
* There is no racial predilection to medulloblastoma.<ref name="pmid2010773">{{cite journal| author=Roberts RO, Lynch CF, Jones MP, Hart MN| title=Medulloblastoma: a population-based study of 532 cases. | journal=J Neuropathol Exp Neurol | year= 1991 | volume= 50 | issue= 2 | pages= 134-44 | pmid=2010773 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2010773 }} </ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Syed Musadiq Ali M.B.B.S.[3]
Overview
Medulloblastoma is the second most common brain tumor among the pediatric population.[1] The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.[2] The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.[3] Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.[2]
Epidemiology and Demographics
Prevalence
- Medulloblastoma is the second most common brain tumor among the pediatric population.[1]
- Medulloblastoma is considered a rare tumor among adults, as it comprises fewer than 2% of all brain tumors among that age group.
Incidence
- The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.[2]
Age
- The incidence of medulloblastoma decreases with age; the median age at diagnosis is between 5 to 7 years.[3]
- The molecular subgroup of medulloblastoma has an influence on the age of presentation such as:[4]
- WNT medulloblastoma subgroup presents among older children
- SHH medulloblastoma subgroup presents among infants and adults
- Group 3 medulloblastoma presents among younger children
- Group 4 medulloblastoma presents among younger children
Gender
- The overall age adjusted incidence rate of medulloblastoma among males is approximately 0.84 per 100,000 individuals in the United States.[2]
- The overall age adjusted incidence rate of medulloblastoma among females is approximately 0.58 per 100,000 individuals in the United States.
- Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.
Race
- There is no racial predilection to medulloblastoma.[5]
References
- ↑ 1.0 1.1 Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015
- ↑ 2.0 2.1 2.2 2.3 McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M; et al. (2013). "Trends in childhood brain tumor incidence, 1973-2009". J Neurooncol. 115 (2): 153–60. doi:10.1007/s11060-013-1212-5. PMC 4056769. PMID 23925828.
- ↑ 3.0 3.1 Bartlett F, Kortmann R, Saran F (2013). "Medulloblastoma". Clin Oncol (R Coll Radiol). 25 (1): 36–45. doi:10.1016/j.clon.2012.09.008. PMID 23245832.
- ↑ Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
- ↑ Roberts RO, Lynch CF, Jones MP, Hart MN (1991). "Medulloblastoma: a population-based study of 532 cases". J Neuropathol Exp Neurol. 50 (2): 134–44. PMID 2010773.