B-cell prolymphocytic leukemia: Difference between revisions

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	B-cell prolymphocytic leukemia
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Latest revision as of 16:33, 1 April 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Carlos A Lopez, M.D. [3]

Synonyms and keywords: B-PLL, Prolymphocytic leukemia, B-cell type

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating B-cell prolymphocytic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

References

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Template:WikiDoc Sources

@@ Line 2: / Line 2: @@
 {{B-cell prolymphocytic leukemia}}
 {{SI}}
-{{CMG}} {{CLG}}
+{{CMG}}; {{AE}}{{Qurrat}}, {{CLG}}
-{{SK}} B-PLL
+{{SK}} B-PLL, Prolymphocytic leukemia, B-cell type
 ==[[B-cell prolymphocytic leukemia overview|Overview]]==
@@ Line 13: / Line 13: @@
 ==[[B-cell prolymphocytic leukemia pathophysiology|Pathophysiology]]==
+==[[B-cell prolymphocytic leukemia causes|Causes]]==
 ==[[B-cell prolymphocytic leukemia differential diagnosis|Differentiating B-cell prolymphocytic leukemia from other Diseases]]==
@@ Line 24: / Line 26: @@
 ==[[B-cell prolymphocytic leukemia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-==Overview==
+==Diagnosis==
-'''B-cell prolymphocytic leukemia''' is a more aggressive but still treatable form of [[leukemia]]. The malignant [[B cells]] are larger than average.
-==Prognosis==
+[[B-cell prolymphocytic leukemia history and symptoms|History and Symptoms ]] | [[ B-cell prolymphocytic leukemia physical examination|Physical Examination]] | [[B-cell prolymphocytic leukemia laboratory findings|Laboratory Findings]] | [[ B-cell prolymphocytic leukemia biopsy|Biopsy]] | [[B-cell prolymphocytic leukemia CT|CT ]] | [[B-cell prolymphocytic leukemia MRI|MRI]] | [[B-cell prolymphocytic leukemia other imaging findings|Other Imaging Findings]] | [[B-cell prolymphocytic leukemia other diagnostic studies|Other Diagnostic Studies]]
-It has a relatively poor prognosis.<ref name="pmid16642047">{{cite journal |author=Del Giudice I, Davis Z, Matutes E, ''et al'' |title=IgVH genes mutation and usage, [[ZAP-70]] and [[CD38]] expression provide new insights on B-cell prolymphocytic leukemia (B-PLL) |journal=Leukemia |volume=20 |issue=7 |pages=1231-7 |year=2006 |pmid=16642047 |doi=10.1038/sj.leu.2404238}}</ref>. But usually has a better prognosis than T-cell prolymphocytic leukemia.<ref name=T-PLL>{{cite web | title = Canadian Cancer Society| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/prolymphocytic-leukemias/?region=on }}</ref>
-==Symptoms==
-* [[Anemia]]<ref name=B-PLL>{{cite web | title = National cancer institute| url = http://seer.cancer.gov/seertools/hemelymph/51f6cf58e3e27c3994bd53f9/ }}</ref>
-* Massive splenomegaly
-* Rapidly rising lymphocyte count
-* [[Thrombocytopenia]]
-* Peripheral lymphadenopathy (minimal)
-==Differential diagnosis==
-* [[Hairy cell leukemia]]<ref name="pmid19110524">{{cite journal |author=Nakashima H, Saito B, Ariizumi H, Matsuda I, Nakamaki T, Tomoyasu S |title=Splenic irradiation as a successful treatment for an elderly patient with B-cell prolymphocytic leukemia |journal=Rinsho Ketsueki |volume=49 |issue=12 |pages=1619–22 |date=December 2008 |pmid=19110524 |doi=10.11406/rinketsu.49.1619}}</ref>
-* [[Waldenström macroglobulinemia]]<ref name="pmid19110524">{{cite journal |author=Nakashima H, Saito B, Ariizumi H, Matsuda I, Nakamaki T, Tomoyasu S |title=Splenic irradiation as a successful treatment for an elderly patient with B-cell prolymphocytic leukemia |journal=Rinsho Ketsueki |volume=49 |issue=12 |pages=1619–22 |date=December 2008 |pmid=19110524 |doi=10.11406/rinketsu.49.1619}}</ref>
-==Epidemiology and demographics==
-* Age: 65-69 years median age<ref name=B-PLL>{{cite web | title = National cancer institute| url = http://seer.cancer.gov/seertools/hemelymph/51f6cf58e3e27c3994bd53f9/ }}</ref>
-* Incidence: ~1% of lymphocytic leukemias
-* Sex: no male or female predominance
-* Survival: 30-50 months median survival
-==Diagnosis exam==
-* Blood chemistry studies
-* Bone marrow aspiration and biopsy
-*Complete blood count (CBC)
-*CT (CAT) scan
-*Cytogenetic analysis
-*Immunophenotyping
-*Peripheral blood smear
-*Physical exam and history (H&P)
 ==Treatment==
-B-cell prolymphocytic leukemia responds better when combinations of [[chemotherapy]] drugs are used. Some combinations that may be used are:<ref name=T-PLL>{{cite web | title = Canadian Cancer Society| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/prolymphocytic-leukemias/?region=on }}</ref>
+[[B-cell prolymphocytic leukemia medical therapy|Medical Therapy]] | [[B-cell prolymphocytic leukemia surgery|Surgery]] | [[B-cell prolymphocytic leukemia primary prevention|Primary Prevention]] | [[B-cell prolymphocytic leukemia secondary prevention|Secondary Prevention]] | [[B-cell prolymphocytic leukemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[B-cell prolymphocytic leukemia future or investigational therapies|Future or Investigational Therapies]]
-* CVP – [[Cyclophosphamide]], [[vincristine]] and [[prednisone]].
-* CHOP – [[Cyclophosphamide]], [[doxorubicin]], [[vincristine]] and [[prednisone]].
-Other chemotherapy drugs (purine analogues) are often used to treat T-cell prolymphocytic leukemia are:
-* [[Fludarabine]]
-* [[Cladribine]]
-* [[Pentostatin]]
-===Biological therapy===
-Monoclonal antibodies are a type of [[biological therapy]] that has been effective in treating certain types of [[leukemias]]. These drugs may be used alone or in combination with chemotherapy to treat prolymphocytic leukemia.
-* [[Alemtuzumab]] seems to be particularly effective in treating T-cell prolymphocytic leukemia. It may be used in people whose [[lymphoma]] is no longer responding to chemotherapy drugs like [[fludarabine]].
-===Splenectomy or radiation therapy to the spleen===
-[[Splenectomy]] and external beam radiation therapy to the spleen may be used in some people with Prolymphocytic leukemia.
-===Stem cell trasplant===
-A [[stem cell transplant]] is sometimes used to treat people with aggressive prolymphocytic leukemia. Many people with prolymphocytic leukemia are older or may not be in good health, so a stem cell trasplant is often not a suitable option for them. However, it may be an effective option for younger people with prolymphocytic leukemia.
 ==References==

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy

B-cell prolymphocytic leukemia: Difference between revisions

Latest revision as of 16:33, 1 April 2019

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