Optic nerve glioma epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
There is no racial predilection to the optic nerve glioma.<ref name="radio"> Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 2 2015</ref> | Optic nerve gliomas affects females and males equally. Optic nerve gliomas commonly affects individuals younger than twenty years of age. There is no racial predilection to the optic nerve glioma.<ref name="radio"> Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 2 2015</ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Optic nerve gliomas typically present in children, and often in the setting of [[NF1]] (10-63%). In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found.<ref name="Medline Plus">Optic glioma. Medline Plus(2015) https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm Accessed on October 5 2015</ref> 5 % of all childhood brain [[tumors]] account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas.<ref name="pmid8009427">{{cite journal| author=Dutton JJ| title=Gliomas of the anterior visual pathway. | journal=Surv Ophthalmol | year= 1994 | volume= 38 | issue= 5 | pages= 427-52 | pmid=8009427 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8009427 }} </ref> It is most common in children who have the [[genetic]] condition [[neurofibromatosis]] 1 (NF1). | *Optic nerve gliomas typically present in children, and often in the setting of [[NF1]] (10-63%). | ||
*In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found.<ref name="Medline Plus">Optic glioma. Medline Plus(2015) https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm Accessed on October 5 2015</ref> | |||
*Five percentage (5%) of all childhood brain [[tumors]] account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas.<ref name="pmid8009427">{{cite journal| author=Dutton JJ| title=Gliomas of the anterior visual pathway. | journal=Surv Ophthalmol | year= 1994 | volume= 38 | issue= 5 | pages= 427-52 | pmid=8009427 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8009427 }} </ref> It is most common in children who have the [[genetic]] condition [[neurofibromatosis]] 1 (NF1). | |||
===Incidence=== | ===Incidence=== | ||
The [[incidence]] of NF-1 among patients of optic nerve glioma is 10-70% and the incidence of optic nerve glioma in patients with NF-1 varies from 8 to 31 %.<ref name="pmid24736941">{{cite journal| author=Nair AG, Pathak RS, Iyer VR, Gandhi RA| title=Optic nerve glioma: an update. | journal=Int Ophthalmol | year= 2014 | volume= 34 | issue= 4 | pages= 999-1005 | pmid=24736941 | doi=10.1007/s10792-014-9942-8 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi? | The [[incidence]] of NF-1 among patients of optic nerve glioma is 10-70% and the incidence of optic nerve glioma in patients with NF-1 varies from 8% to 31%.<ref name="pmid24736941">{{cite journal| author=Nair AG, Pathak RS, Iyer VR, Gandhi RA| title=Optic nerve glioma: an update. | journal=Int Ophthalmol | year= 2014 | volume= 34 | issue= 4 | pages= 999-1005 | pmid=24736941 | doi=10.1007/s10792-014-9942-8 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi? | ||
dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24736941 }} </ref> | dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24736941 }} </ref> | ||
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===Age=== | ===Age=== | ||
The mean age of presentation of optic nerve glioma is 8.8 years. | The mean age of presentation of optic nerve glioma is 8.8 years.<ref name="pmid3275755">{{cite journal| author=Alvord EC, Lofton S| title=Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment. | journal=J Neurosurg | year= 1988 | volume= 68 | issue= 1 | pages= 85-98 | pmid=3275755 | doi=10.3171/jns.1988.68.1.0085 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3275755 }} </ref> The majority of optic nerve gliomas occur in children. They are usually slow-growing and noncancerous and almost always occur before age 20.<ref name="Medline Plus">Optic glioma. Medline Plus(2015) https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm Accessed on October 5 2015</ref> | ||
<ref name="pmid3275755">{{cite journal| author=Alvord EC, Lofton S| title=Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment. | journal=J Neurosurg | year= 1988 | volume= 68 | issue= 1 | pages= 85-98 | pmid=3275755 | doi=10.3171/jns.1988.68.1.0085 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3275755 }} </ref> | {| style="border: 0px; font-size: 90%; margin: 3px; width: 300px" align=center | ||
{| style="border: 0px; font-size: 90%; margin: 3px; width: | |||
|valign=top| | |valign=top| | ||
|+ | |+ | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:Before the age 18 months | :Before the age 18 months | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | | ||
25% | 25% | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | | ||
:Before the age of 5 | :Before the age of 5 | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | | ||
50% | 50% | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | ||
:Before the age of 10 | :Before the age of 10 | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | | ||
75% | 75% | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | | ||
:Before the age of 20 | :Before the age of 20 | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="text-align: center; padding: 5px 5px; background: #F5F5F5;" | | ||
90% | 90% | ||
|- | |- | ||
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===Race=== | ===Race=== | ||
There | There is no racial predilection to the development of optic nerve glioma. | ||
==References== | ==References== | ||
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[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Ophthalmology]] | [[Category:Ophthalmology]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Ophthalmology]] | |||
[[Category:Neurosurgery]] | |||
Latest revision as of 14:47, 27 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Optic nerve gliomas affects females and males equally. Optic nerve gliomas commonly affects individuals younger than twenty years of age. There is no racial predilection to the optic nerve glioma.[1]
Epidemiology and Demographics
- Optic nerve gliomas typically present in children, and often in the setting of NF1 (10-63%).
- In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found.[2]
- Five percentage (5%) of all childhood brain tumors account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas.[3] It is most common in children who have the genetic condition neurofibromatosis 1 (NF1).
Incidence
The incidence of NF-1 among patients of optic nerve glioma is 10-70% and the incidence of optic nerve glioma in patients with NF-1 varies from 8% to 31%.[4]
Gender
Males and females are equally affected.
Age
The mean age of presentation of optic nerve glioma is 8.8 years.[5] The majority of optic nerve gliomas occur in children. They are usually slow-growing and noncancerous and almost always occur before age 20.[2]
| Age of onset of optic nerve glioma | Percentage of optic nerve glioma diagnosed |
|---|---|
|
25% |
|
50% |
|
75% |
|
90% |
Race
There is no racial predilection to the development of optic nerve glioma.
References
- ↑ Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 2 2015
- ↑ 2.0 2.1 Optic glioma. Medline Plus(2015) https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm Accessed on October 5 2015
- ↑ Dutton JJ (1994). "Gliomas of the anterior visual pathway". Surv Ophthalmol. 38 (5): 427–52. PMID 8009427.
- ↑ Nair AG, Pathak RS, Iyer VR, Gandhi RA (2014). [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?
dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24736941 "Optic nerve glioma: an update"] Check
|url=value (help). Int Ophthalmol. 34 (4): 999–1005. doi:10.1007/s10792-014-9942-8. PMID 24736941. line feed character in|url=at position 54 (help) - ↑ Alvord EC, Lofton S (1988). "Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment". J Neurosurg. 68 (1): 85–98. doi:10.3171/jns.1988.68.1.0085. PMID 3275755.