Ependymoma medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
The predominant therapy for ependymoma is surgical resection. Adjunctive chemoradiation may be required. | |||
== | ==Chemotherapy== | ||
* | *There is no evidence to date that adjuvant chemotherapy, including the use of myeloablative chemotherapy, improves the outcome for patients with totally resected, nondisseminated ependymoma.<ref name="pmid16874765">{{cite journal| author=Zacharoulis S, Levy A, Chi SN, Gardner S, Rosenblum M, Miller DC et al.| title=Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue. | journal=Pediatr Blood Cancer | year= 2007 | volume= 49 | issue= 1 | pages= 34-40 | pmid=16874765 | doi=10.1002/pbc.20935 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16874765 }} </ref> | ||
*Current treatment approaches do not include chemotherapy as a standard component of primary therapy for children with newly diagnosed ependymomas that are completely resected. | |||
*[[Etoposide]] may be used in recurrent cases. | |||
==Radiation Therapy== | ==Radiation Therapy== | ||
* | *Radiation therapy consisting of 54 [[gray]] to 55.8 [[gray]] is recommended for children aged 3 years and older who are diagnosed with well-differentiated ependymomas.<ref name=Cancergov> Ependymoma treatment. http://www.cancer.gov/types/brain/hp/child-ependymoma-treatment-pdq#section/_48 URL Accessed on 10/13/2015.</ref> | ||
*It is not necessary to treat the entire [[CNS]] (whole [[brain]] and [[spine]]) because these tumors usually recur initially at the local site. | |||
*When possible, patients should be treated in a center experienced with the delivery of highly conformal [[radiation therapy]] (including intensity-modulated radiation therapy or charged-particle radiation therapy) to pediatric patients with [[brain tumor]]s. | |||
==References== | ==References== | ||
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Latest revision as of 22:19, 26 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
The predominant therapy for ependymoma is surgical resection. Adjunctive chemoradiation may be required.
Chemotherapy
- There is no evidence to date that adjuvant chemotherapy, including the use of myeloablative chemotherapy, improves the outcome for patients with totally resected, nondisseminated ependymoma.[1]
- Current treatment approaches do not include chemotherapy as a standard component of primary therapy for children with newly diagnosed ependymomas that are completely resected.
- Etoposide may be used in recurrent cases.
Radiation Therapy
- Radiation therapy consisting of 54 gray to 55.8 gray is recommended for children aged 3 years and older who are diagnosed with well-differentiated ependymomas.[2]
- It is not necessary to treat the entire CNS (whole brain and spine) because these tumors usually recur initially at the local site.
- When possible, patients should be treated in a center experienced with the delivery of highly conformal radiation therapy (including intensity-modulated radiation therapy or charged-particle radiation therapy) to pediatric patients with brain tumors.
References
- ↑ Zacharoulis S, Levy A, Chi SN, Gardner S, Rosenblum M, Miller DC; et al. (2007). "Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue". Pediatr Blood Cancer. 49 (1): 34–40. doi:10.1002/pbc.20935. PMID 16874765.
- ↑ Ependymoma treatment. http://www.cancer.gov/types/brain/hp/child-ependymoma-treatment-pdq#section/_48 URL Accessed on 10/13/2015.