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| __NOTOC__ | | __NOTOC__ |
| {{Anaplastic large cell lymphoma}} | | [[Image:Home_logo1.png|right|250px|link=http://www.wikidoc.org/index.php/Anaplastic_large_cell_lymphoma]] |
| {{CMG}} | | {{CMG}}; {{AE}} {{AS}} |
| ==Differential diagnosis== | | ==Overview== |
| *As the appearance of the hallmark cells, pattern of growth (nesting within lymph nodes) and positivity for EMA may mimic [[metastatic]] [[carcinoma]], it is important to include markers for [[cytokeratin]] in any diagnostic panel (these will be negative in the case of anaplastic lymphoma).
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| *Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas). These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV.
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| *Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution. ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in [[rhabdomyosarcoma]]s.
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| *[[ALCL ALK negative]]
| | ==Differential Diagnosis== |
| *Primary cutaneous ALCL
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| *Diffuse large B-cell lymphoma, anaplastic type
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| *Diffuse large B-cell lymphoma, plasmablastic type
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| *[[Hodgkin lymphoma]]
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| == Differential Diagnosis==
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| *Peripheral T-cell lymphoma-not otherwise specified (PTCL-NOS)<ref name="pmid22789917">{{cite journal| author=Ferreri AJ, Govi S, Pileri SA, Savage KJ| title=Anaplastic large cell lymphoma, ALK-negative. | journal=Crit Rev Oncol Hematol | year= 2013 | volume= 85 | issue= 2 | pages= 206-15 | pmid=22789917 | doi=10.1016/j.critrevonc.2012.06.004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22789917 }} </ref><ref name="ALK+/ALK-">{{cite web|url=http://www.bloodjournal.org/content/111/12/5496?sso-checked=true|title=ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project}}</ref>
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| *Classical [[Hodgkin's lymphoma]]<ref name="pmid22789917">{{cite journal| author=Ferreri AJ, Govi S, Pileri SA, Savage KJ| title=Anaplastic large cell lymphoma, ALK-negative. | journal=Crit Rev Oncol Hematol | year= 2013 | volume= 85 | issue= 2 | pages= 206-15 | pmid=22789917 | doi=10.1016/j.critrevonc.2012.06.004 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22789917 }} </ref>
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| *Primary cutaneous anaplastic large cell lymphoma<ref name=Swerdlow>{{cite book | last = Swerdlow | first = Steven | title = WHO classification of tumours of haematopoietic and lymphoid tissues | publisher = International Agency for Research on Cancer | location = Lyon, France | year = 2008 | isbn = 9789283224310 }}</ref>
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| *[[Anaplastic large cell lymphoma, ALK positive]]<ref name="ALK+/ALK-">{{cite web|url=http://www.bloodjournal.org/content/111/12/5496?sso-checked=true|title=ALK- anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project}}</ref>
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| ==References== | | ==References== |
| {{reflist|2}} | | {{reflist|2}} |
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| {{WH}} | | {{WH}} |
| {{WS}} | | {{WS}} |
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| [[Category:Hematology]] | | [[Category:Hematology]] |
| [[Category:Types of cancer]] | | [[Category:Types of cancer]] |
| | [[Category:Up-To-Date]] |
| | [[Category:Oncology]] |
| | [[Category:Medicine]] |
| | [[Category:Hematology]] |
| | [[Category:Immunology]] |
