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| __NOTOC__ | | __NOTOC__ |
| {{Chronic lymphocytic leukemia}} | | [[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Chronic_lymphocytic_leukemia]] |
| {{CMG}} {{AE}}{{HL}} | | {{CMG}} {{AE}}{{HL}} {{HK}} |
| ==Overview== | | ==Overview== |
| * Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.<ref>Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
| | Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]]. |
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| ==Differenting Chronic lymphocytic leukemia from other Diseases== | | ==Differenting Chronic lymphocytic leukemia from other Diseases== |
| * Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss, night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
| | Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]]. |
| * The table below summarizes how to differentiate chronic lymphocytic leukemia from other conditions that cause similar presentation:<ref>Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
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| <br>
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| {| style="cellpadding=0; cellspacing= 0; width: 1100px;"
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| ! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''Surface Immunoglobulin'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD5'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD22/FMC7'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD23'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD79b'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD103'''}}
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Chronic lymphocytic leukaemia'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center |
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| '''Weakly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center |
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center |
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive/Negative'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Prolymphocytic leukaemia'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Hairy cell leukaemia'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive/Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Mantle cell lymphoma'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| Negative
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Follicular lymphoma'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| |}
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| <br>
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| * Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:<ref name="wiki>Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015</ref>
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| :* Splenic marginal zone lymphoma
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| :* Nodal marginal zone lymphoma
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| :* Lymphoplasmacytic lymphoma
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| :* Sézary syndrome
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| :* Smoldering adult T cell leukemia
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| ==References== | | ==References== |
| {{reflist|2}} | | {{reflist|2}} |
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| [[Category:Disease]]
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| [[Category:Hematology]]
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| [[Category:Mature chapter]]
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| {{Hematology}}
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| {{Hematological malignancy histology}}
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