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{{Hepatocellular adenoma}}
{{Hepatocellular adenoma}}


{{CMG}}; {{AE}} {{NM}}
{{CMG}}; {{AE}} {{ZAS}}
==Overview==
Hepatocellular adenoma was first described in 1958 by Edmondson as an encapsulated [[liver tumor]] that does not contain [[Bile duct|bile ducts]]. Baum reported the important relationship between [[Oral contraceptive|oral contraceptive use]] and hepatocellular adenoma development in 1973. Edmondson, in 1976, published a [[case control study]] giving further [[evidence]] of this [[Association (statistics)|association]].


==Overview==
==Historical Perspective==
==Historical perspective==
* In 1958, hepatocellular adenoma was first described by Edmondson as an encapsulated [[liver tumor]] that does not contain [[Bile duct|bile ducts]], when he identified two such [[Lesion|lesions]] in 50,000 [[Autopsy|autopsies]].<ref>{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188  }}</ref><ref>{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188  }}</ref>
Liver cell adenoma was first discovered by Edmondson in 1958 following 50 000 autopsies. He described it as an encapsulated liver tumour that does not contain bile ducts, when he identified two such lesions.<ref name="pmid18333188">{{cite journal| author=Barthelmes L, Tait IS| title=Liver cell adenoma and liver cell adenomatosis. | journal=HPB (Oxford) | year= 2005 | volume= 7 | issue= 3 | pages= 186-96 | pmid=18333188 | doi=10.1080/13651820510028954 | pmc=PMC2023950 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18333188  }} </ref>
* In 1973, Baum reported the important relationship between [[Oral contraceptive|oral contraceptive use]] and development of hepatocellular adenomas in seven [[Patient|patients]].<ref>{{Cite journal
| author = [[G. Klatskin]]
| title = Hepatic tumors: possible relationship to use of oral contraceptives
| journal = [[Gastroenterology]]
| volume = 73
| issue = 2
| pages = 386–394
| year = 1977
| month = August
| pmid = 194813
}}</ref><ref>{{Cite journal
| author = [[J. K. Baum]], [[J. J. Bookstein]], [[F. Holtz]] & [[E. W. Klein]]
| title = Possible association between benign hepatomas and oral contraceptives
| journal = [[Lancet (London, England)]]
| volume = 2
| issue = 7835
| pages = 926–929
| year = 1973
| month = October
| pmid = 4126557
}}</ref>
* In the 1970s, several subsequent [[case series]] supported the [[hypothesis]] of an [[Association (statistics)|association]] between [[oral contraceptive pill|oral contraceptive pills]] and hepatocellular adenoma.<ref>{{Cite journal
| author = [[E. Horvath]], [[K. Kovacs]] & [[R. C. Ross]]
| title = Letter: Benign hepatoma in a young woman on contraceptive steroids
| journal = [[Lancet (London, England)]]
| volume = 1
| issue = 7853
| pages = 357–358
| year = 1974
| month = March
| pmid = 4131203
}}</ref>
* In 1976, Edmondson published a [[case control study]] giving further [[evidence]] of this [[Association (statistics)|association]]. <ref>{{Cite journal
| author = [[H. A. Edmondson]], [[B. Henderson]] & [[B. Benton]]
| title = Liver-cell adenomas associated with use of oral contraceptives
| journal = [[The New England journal of medicine]]
| volume = 294
| issue = 9
| pages = 470–472
| year = 1976
| month = February
| doi = 10.1056/NEJM197602262940904
| pmid = 173996
}}</ref>


==References==
==References==
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Latest revision as of 20:40, 19 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zahir Ali Shaikh, MD[2]

Overview

Hepatocellular adenoma was first described in 1958 by Edmondson as an encapsulated liver tumor that does not contain bile ducts. Baum reported the important relationship between oral contraceptive use and hepatocellular adenoma development in 1973. Edmondson, in 1976, published a case control study giving further evidence of this association.

Historical Perspective

References

  1. ↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  2. ↑ Barthelmes L, Tait IS (2005). "Liver cell adenoma and liver cell adenomatosis". HPB (Oxford). 7 (3): 186–96. doi:10.1080/13651820510028954. PMC 2023950. PMID 18333188.
  3. ↑ G. Klatskin (1977). "Hepatic tumors: possible relationship to use of oral contraceptives". Gastroenterology. 73 (2): 386–394. PMID 194813. Unknown parameter |month= ignored (help)
  4. ↑ J. K. Baum, J. J. Bookstein, F. Holtz & E. W. Klein (1973). "Possible association between benign hepatomas and oral contraceptives". Lancet (London, England). 2 (7835): 926–929. PMID 4126557. Unknown parameter |month= ignored (help)
  5. ↑ E. Horvath, K. Kovacs & R. C. Ross (1974). "Letter: Benign hepatoma in a young woman on contraceptive steroids". Lancet (London, England). 1 (7853): 357–358. PMID 4131203. Unknown parameter |month= ignored (help)
  6. ↑ H. A. Edmondson, B. Henderson & B. Benton (1976). "Liver-cell adenomas associated with use of oral contraceptives". The New England journal of medicine. 294 (9): 470–472. doi:10.1056/NEJM197602262940904. PMID 173996. Unknown parameter |month= ignored (help)


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