Sandbox: staging

Rai Staging System

According to the Rai Staging System, there are five stages of chronic lymphocytic leukemia based on the degree of lymphocytosis, hemoglobin level, platelets level, the presence of splenomegaly, and the presence of lymphadenopathy.

Stage	Hemoglobin Level	Platelets Level	Lymphocytosis	Splenomegaly	Lymphadenopathy	Median Survival
Stage 0	>11 g/dL	>100,000/L	Present	Absent	Absent	>150 months
Stage 1	>11 g/dL	>100,000/L	Present	Absent	Present	101 months
Stage 2	>11 g/dL	>100,000/L	Present	Present	Present or absent	71 months
Stage 3	<11 g/dL	>100,000/L	Present	Present or absent	Present or absent	19 months
Stage 4	<11 g/dL or >11g/dL	<100,000/L	Present	Present or absent	Present or absent	19 months

Binet Staging System

According to the Binet Staging System, there are three stages of chronic lymphocytic leukemia based on the degree of lymphocytosis, the presence of anemia or thrombocytopenia, and the involvement of three or more lymph node regions.

Stage	Lymphocytosis	Anemia or Thrombocytopenia	Lymphadenopathy	Median Survival
Stage A	Present	Absent	Absent	Nearly normal age and sex adjusted survival rate
Stage B	Present	Absent	Present	7 years
Stage C	Present	Present	Present or Absent	2 years