Ependymoma pathophysiology: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
(18 intermediate revisions by 4 users not shown)
Line 4: Line 4:


==Overview==
==Overview==
On [[gross pathology]], a well-encapsulated [[tumor]] which arises from the floor of the [[fourth ventricle]], situated in the lower back portion of the [[brain]] is a characteristic finding of ependymoma. On [[microscopic]] histopathological analysis, perivascular pseudorosettes are characteristic findings of ependymoma. Development of ependymoma is the result of multiple genetic mutations (''ERBB2'', ''ERBB4'', ''[[MMP2]]'', ''MMP14'', ''[[NOTCH1]]'', and ''[[MEN1]]'').<ref name=Epe>Kumar, et al. (2005). The Central Nervous System. Pathologic Basis of Disease. 7th Edition. Philadelphia: Elsevier Saunders.</ref><ref name=Wikipedia> ependymoma https://en.wikipedia.org/wiki/Pediatric_ependymoma#Cell_of_origin URL Accessed on 10/08/2015</ref>
On [[gross pathology]], a well-encapsulated [[tumor]] which arises from the floor of the [[fourth ventricle]], situated in the lower back portion of the [[brain]] is a characteristic finding of ependymoma. On [[microscopic]] histopathological analysis, perivascular pseudorosettes are characteristic findings of ependymoma. Development of ependymoma is the result of multiple genetic mutations (''ERBB2'', ''ERBB4'', ''[[MMP2]]'', ''MMP14'', ''[[NOTCH1]]'', and ''[[MEN1]]'').<ref name="Epe">Kumar, et al. (2005). The Central Nervous System. Pathologic Basis of Disease. 7th Edition. Philadelphia: Elsevier Saunders.</ref>
==Genetics==
 
 
 
*One expression-defined group occurs primarily in young children and is characterized by a largely balanced genomic profile with an increased occurrence of ''chromosome 1q'' and proteins such as [[tenascin C]] and [[epidermal growth factor]] receptor.<ref name="pmid10967185">{{cite journal| author=Korshunov A, Golanov A, Timirgaz V| title=Immunohistochemical markers for intracranial ependymoma recurrence. An analysis of 88 cases. | journal=J Neurol Sci | year= 2000 | volume= 177 | issue= 1 | pages= 72-82 | pmid=10967185 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10967185  }} </ref><ref name="pmid16609018">{{cite journal| author=Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B et al.| title=Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. | journal=Clin Cancer Res | year= 2006 | volume= 12 | issue= 7 Pt 1 | pages= 2070-9 | pmid=16609018 | doi=10.1158/1078-0432.CCR-05-2363 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16609018  }} </ref><ref name="pmid26075792">{{cite journal| author=Mohankumar KM, Currle DS, White E, Boulos N, Dapper J, Eden C et al.| title=An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes. | journal=Nat Genet | year= 2015 | volume= 47 | issue= 8 | pages= 878-87 | pmid=26075792 | doi=10.1038/ng.3323 | pmc=4520751 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26075792  }} </ref><ref name="pmid26690880">{{cite journal| author=Abedalthagafi MS, Wu MP, Merrill PH, Du Z, Woo T, Sheu SH et al.| title=Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours. | journal=J Pathol | year= 2016 | volume= 238 | issue= 4 | pages= 584-97 | pmid=26690880 | doi=10.1002/path.4682 | pmc=5364032 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26690880  }} </ref><ref name="pmid25775275">{{cite journal| author=Georgescu MM, Yell P, Mobley BC, Shang P, Georgescu T, Wang SH et al.| title=NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. | journal=Acta Neuropathol Commun | year= 2015 | volume= 3 | issue=  | pages= 11 | pmid=25775275 | doi=10.1186/s40478-015-0197-z | pmc=4352254 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25775275  }} </ref><ref name="pmid28617804">{{cite journal| author=Andreiuolo F, Le Teuff G, Bayar MA, Kilday JP, Pietsch T, von Bueren AO et al.| title=Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification. | journal=PLoS One | year= 2017 | volume= 12 | issue= 6 | pages= e0178351 | pmid=28617804 | doi=10.1371/journal.pone.0178351 | pmc=5472261 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28617804  }} </ref><ref name="pmid27550150">{{cite journal| author=Araki A, Chocholous M, Gojo J, Dorfer C, Czech T, Heinzl H et al.| title=Chromosome 1q gain and tenascin-C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma. | journal=Acta Neuropathol Commun | year= 2016 | volume= 4 | issue= 1 | pages= 88 | pmid=27550150 | doi=10.1186/s40478-016-0349-9 | pmc=4994287 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27550150  }} </ref>
*The second expression-defined group occurs primarily in older children and adults and is characterized by a numerous [[cytogenetic]] abnormalities involving the whole [[chromosome]] or chromosomal arms.<ref name="pmid22322993">{{cite journal| author=Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R et al.| title=A prognostic gene expression signature in infratentorial ependymoma. | journal=Acta Neuropathol | year= 2012 | volume= 123 | issue= 5 | pages= 727-38 | pmid=22322993 | doi=10.1007/s00401-012-0941-4 | pmc=PMC4013829 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22322993  }} </ref>
*Genes involved in ependymoma formation and progression are:<ref name="pmid27390862">{{cite journal| author=Zakrzewska M, Fendler W, Zakrzewski K, Sikorska B, Grajkowska W, Dembowska-Bagińska B et al.| title=Altered MicroRNA Expression Is Associated with Tumor Grade, Molecular Background and Outcome in Childhood Infratentorial Ependymoma. | journal=PLoS One | year= 2016 | volume= 11 | issue= 7 | pages= e0158464 | pmid=27390862 | doi=10.1371/journal.pone.0158464 | pmc=4938415 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27390862  }} </ref>
:*''ERBB2''
:*''ERBB4''
:*Human telomerase [[reverse transcriptase]] ''[[TERT]]''
:*''KIT'' receptor [[tyrosine kinase]] and phospho-''KIT'' receptor expression is associated with tumor progression
:*''[[MMP2]]'' and ''MMP14'' mutations appear to also play a role in tumor growth and progression in intracranial cases.
:*''[[NOTCH1]]'' mutations have been found in approximately 8% of pediatric ependymomas
:* ''[[MEN1]]'' mutations are occasionally found in pediatric ependymomas.
:*''TPR'' and ''CHIBBY'' mutations have been identified in pediatric ependymomas.
:* ''[[S100A6]]'' and ''[[S100A4]]'' on chromosome 1q have also been found to correspond to supratentorial tumor development and tumors occurring before the age of 3 years.
 
==Associated Conditions==
*The subependymal giant-cell astrocytoma, also called giant-cell glioma, is typically associated with [[tuberous sclerosis]] but can occur independently.


==Pathology==
==Pathology==
*Ependymomas represent a relatively broad group of glial tumours which share common origin from differentiated ependymal cells lining the ventricles of the brain or the central canal of the spinal cord. They account for ~5% of all neuroepithelial neoplasms, ~10% of all paediatric brain tumours and up to 33% of brain tumours occurring in those less than 3 years of age.
*Ependymomas represent a relatively broad group of glial tumors which share common origin from differentiated ependymal cells lining the ventricles of the brain or the central canal of the spinal cord. They account for 5% of all neuroepithelial neoplasms.
*Ependymomas can occur anywhere, but certain location are typical. Common locations include:
*Ependymomas can occur anywhere, but certain location are typical. Common locations include:
:*Floor of the [[fourth ventricle]] (common location in children)
:*Floor of the [[fourth ventricle]] (common location in children)
Line 14: Line 33:
:*[[Supratentorial]] ependymoma
:*[[Supratentorial]] ependymoma
*The subependymomas, variant of the ependymoma, arise in the fourth ventricle but may occur in the [[septum pellucidum]] and the cervical spinal cord.
*The subependymomas, variant of the ependymoma, arise in the fourth ventricle but may occur in the [[septum pellucidum]] and the cervical spinal cord.
===Gross Pathology===
==Gross Pathology==
*Ependymomas are well-encapsulated tumors and usually arise from the floor of the [[fourth ventricle]], situated in the lower back portion of the brain.
*Ependymomas are well-encapsulated tumors which usually arise from the floor of the [[fourth ventricle]].
<Gallery>
<gallery>
Epyndemomas gross.jpg| Fourth ventricle ependymomas frequently extend out of the ventricle into the subarachnoid space.<ref name=libre>EPENDYMOMA. http://librepathology.org/wiki/index.php/File:AFIP405713G-EPENDYMOMA.jpg 2015. URL Accessed on 10 6, 2015</ref>
Epyndemomas gross.jpg| Fourth ventricle ependymomas frequently extend out of the ventricle into the [[subarachnoid space]].<ref name=libre>EPENDYMOMA. http://librepathology.org/wiki/index.php/File:AFIP405713G-EPENDYMOMA.jpg 2015. URL Accessed on 10 6, 2015</ref>
</gallery>
</gallery>
===Microscopic Pathology===
==Microscopic Pathology==
*Ependymomas are composed of cells with regular, round to oval [[nuclei]]. There is a variably dense fibrillary background.
*Ependymomas are composed of cells with regular, round to oval [[nuclei]]. There is a variably dense fibrillary background.
*Tumor cells may form gland-like round or elongated structures that resemble the embryologic [[ependyma|ependymal canal]], with long, delicate processes extending into the lumen; more frequently present are perivascular pseudorosettes in which tumor cells are arranged around vessels with an intervening zone consisting of thin ependymal processes directed toward the wall of the vessel.<ref name=Epe>Kumar, et al. (2005). The Central Nervous System. Pathologic Basis of Disease. 7th Edition. Philadelphia: Elsevier Saunders.</ref>
*Tumor cells may form gland-like round or elongated structures that resemble the embryologic [[ependyma|ependymal canal]], with long, delicate processes extending into the lumen; more frequently present are perivascular pseudorosettes in which tumor cells are arranged around vessels with an intervening zone consisting of thin ependymal processes directed toward the wall of the vessel.<ref name="Epe">Kumar, et al. (2005). The Central Nervous System. Pathologic Basis of Disease. 7th Edition. Philadelphia: Elsevier Saunders.</ref>
*Ependymal rosettes are rare but pathognomonic feature.
*Ependymal rosettes are rare but pathognomonic feature.


<Gallery>
<gallery>
Image:532px-Ependymoma low intermed mag.jpg|Micrograph of an ependymoma. H&E stain show pseudoressettes pattern of ependymal cells.<ref name=Wikipedia> Ependymoma. https://en.wikipedia.org/wiki/Ependymoma#/media/File:Ependymoma_low_intermed_mag.jpg. URL Accessed on 10 6, 2015</ref>
Image:532px-Ependymoma low intermed mag.jpg|Micrograph of an ependymoma. H&E stain show pseudoressettes pattern of ependymal cells.<ref name=Wikipedia> Ependymoma. https://en.wikipedia.org/wiki/Ependymoma#/media/File:Ependymoma_low_intermed_mag.jpg. URL Accessed on 10 6, 2015</ref>
Image:True ependymal rossettes.jpg|True ependymal rosette consisting of tumor cells arranged around well-defined lumens forming gland-like structures.<ref name=radiopaedia> Image courtesy of Dr Dharam Ramnani[http://www.radiopaedia.org Radiopaedia] (original file
Image:True ependymal rossettes.jpg|True ependymal rosette consisting of tumor cells arranged around well-defined lumens forming gland-like structures.<ref name=radiopaedia> Image courtesy of Dr Dharam Ramnani[http://www.radiopaedia.org Radiopaedia] (original file
Line 32: Line 51:
</gallery>
</gallery>


==Associated Conditions==
The subependymal giant-cell astrocytoma, also called giant-cell glioma, is typically associated with [[tuberous sclerosis]] but can occur independently.
==Genetics==
*[[Posterior fossa]] ependymoma can be divided into the following two groups based on distinctive patterns of [[gene expression]].<ref name="pmid22322993">{{cite journal| author=Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R et al.| title=A prognostic gene expression signature in infratentorial ependymoma. | journal=Acta Neuropathol | year= 2012 | volume= 123 | issue= 5 | pages= 727-38 | pmid=22322993 | doi=10.1007/s00401-012-0941-4 | pmc=PMC4013829 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22322993  }} </ref><ref name="pmid21840481">{{cite journal| author=Witt H, Mack SC, Ryzhova M, Bender S, Sill M, Isserlin R et al.| title=Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma. | journal=Cancer Cell | year= 2011 | volume= 20 | issue= 2 | pages= 143-57 | pmid=21840481 | doi=10.1016/j.ccr.2011.07.007 | pmc=PMC4154494 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21840481  }} </ref><ref name=Cancergove> Eoendymoma. http://www.cancer.gov/types/brain/hp/child-ependymoma-treatment-pdq#section/_35 URL Accessed on 10 6 2015.</ref>


*One expression-defined group occurs primarily in young children and is characterized by a largely balanced genomic profile with an increased occurrence of ''chromosome 1q'' and proteins such as [[tenascin C]] and [[epidermal growth factor]] receptor.<ref name="pmid10967185">{{cite journal| author=Korshunov A, Golanov A, Timirgaz V| title=Immunohistochemical markers for intracranial ependymoma recurrence. An analysis of 88 cases. | journal=J Neurol Sci | year= 2000 | volume= 177 | issue= 1 | pages= 72-82 | pmid=10967185 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10967185  }} </ref><ref name="pmid16609018">{{cite journal| author=Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B et al.| title=Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma. | journal=Clin Cancer Res | year= 2006 | volume= 12 | issue= 7 Pt 1 | pages= 2070-9 | pmid=16609018 | doi=10.1158/1078-0432.CCR-05-2363 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16609018  }} </ref>
*The second expression-defined group occurs primarily in older children and adults and is characterized by a numerous [[cytogenetic]] abnormalities involving the whole [[chromosome]] or chromosomal arms.<ref name="pmid22322993">{{cite journal| author=Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R et al.| title=A prognostic gene expression signature in infratentorial ependymoma. | journal=Acta Neuropathol | year= 2012 | volume= 123 | issue= 5 | pages= 727-38 | pmid=22322993 | doi=10.1007/s00401-012-0941-4 | pmc=PMC4013829 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22322993  }} </ref>
*Genes involved in ependymoma formation and progression are:<ref name=Wikipedia> ependymoma https://en.wikipedia.org/wiki/Pediatric_ependymoma#Cell_of_origin URL Accessed on 10/08/2015</ref>
:*''ERBB2''
:*''ERBB4''
:*Human telomerase [[reverse transcriptase]] ''[[TERT]]''
:*''KIT'' receptor [[tyrosine kinase]] and phospho-''KIT'' receptor expression is associated with tumor progression
:*''[[MMP2]]'' and ''MMP14'' appear to also play a role in tumor growth and progression in intracranial cases.
:*''[[NOTCH1]]'' mutations have been found in approximately 8% of pediatric ependymomas
:* ''[[MEN1]]'' mutations are occasionally found in pediatric ependymomas.
:*''TPR'' and ''CHIBBY'', have been identified in pediatric ependymomas.
:* ''[[S100A6]]'' and ''[[S100A4]]'' on chromosome 1q have also been found to correspond to supratentorial tumor development and tumors occurring before the age of 3 years old.


==References==
==References==
Line 60: Line 61:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Neurology]]
[[Category:Neurosurgery]]

Latest revision as of 18:08, 24 September 2019

Ependymoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Differentiating Ependymoma from other Diseases

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Staging

Laboratory Findings

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ependymoma pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ependymoma pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ependymoma pathophysiology

CDC on Ependymoma pathophysiology

Ependymoma pathophysiology in the news

Blogs on Ependymoma pathophysiology

Directions to Hospitals Treating Ependymoma

Risk calculators and risk factors for Ependymoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [3]

Overview

On gross pathology, a well-encapsulated tumor which arises from the floor of the fourth ventricle, situated in the lower back portion of the brain is a characteristic finding of ependymoma. On microscopic histopathological analysis, perivascular pseudorosettes are characteristic findings of ependymoma. Development of ependymoma is the result of multiple genetic mutations (ERBB2, ERBB4, MMP2, MMP14, NOTCH1, and MEN1).[1]

Genetics

  • One expression-defined group occurs primarily in young children and is characterized by a largely balanced genomic profile with an increased occurrence of chromosome 1q and proteins such as tenascin C and epidermal growth factor receptor.[2][3][4][5][6][7][8]
  • The second expression-defined group occurs primarily in older children and adults and is characterized by a numerous cytogenetic abnormalities involving the whole chromosome or chromosomal arms.[9]
  • Genes involved in ependymoma formation and progression are:[10]
  • ERBB2
  • ERBB4
  • Human telomerase reverse transcriptase TERT
  • KIT receptor tyrosine kinase and phospho-KIT receptor expression is associated with tumor progression
  • MMP2 and MMP14 mutations appear to also play a role in tumor growth and progression in intracranial cases.
  • NOTCH1 mutations have been found in approximately 8% of pediatric ependymomas
  • MEN1 mutations are occasionally found in pediatric ependymomas.
  • TPR and CHIBBY mutations have been identified in pediatric ependymomas.
  • S100A6 and S100A4 on chromosome 1q have also been found to correspond to supratentorial tumor development and tumors occurring before the age of 3 years.

Associated Conditions

  • The subependymal giant-cell astrocytoma, also called giant-cell glioma, is typically associated with tuberous sclerosis but can occur independently.

Pathology

  • Ependymomas represent a relatively broad group of glial tumors which share common origin from differentiated ependymal cells lining the ventricles of the brain or the central canal of the spinal cord. They account for 5% of all neuroepithelial neoplasms.
  • Ependymomas can occur anywhere, but certain location are typical. Common locations include:
  • The subependymomas, variant of the ependymoma, arise in the fourth ventricle but may occur in the septum pellucidum and the cervical spinal cord.

Gross Pathology

  • Ependymomas are well-encapsulated tumors which usually arise from the floor of the fourth ventricle.

Microscopic Pathology

  • Ependymomas are composed of cells with regular, round to oval nuclei. There is a variably dense fibrillary background.
  • Tumor cells may form gland-like round or elongated structures that resemble the embryologic ependymal canal, with long, delicate processes extending into the lumen; more frequently present are perivascular pseudorosettes in which tumor cells are arranged around vessels with an intervening zone consisting of thin ependymal processes directed toward the wall of the vessel.[1]
  • Ependymal rosettes are rare but pathognomonic feature.
  • Micrograph of an ependymoma. H&E stain show pseudoressettes pattern of ependymal cells.[12]

    Micrograph of an ependymoma. H&E stain show pseudoressettes pattern of ependymal cells.[12]

  • True ependymal rosette consisting of tumor cells arranged around well-defined lumens forming gland-like structures.<ref name=radiopaedia> Image courtesy of Dr Dharam RamnaniRadiopaedia (original file

    True ependymal rosette consisting of tumor cells arranged around well-defined lumens forming gland-like structures.<ref name=radiopaedia> Image courtesy of Dr Dharam RamnaniRadiopaedia (original file

  • Higher magnification of one of the true ependymal rosettes showing a collar of cells around a central lumen forming a gland-like structure.[13]

    Higher magnification of one of the true ependymal rosettes showing a collar of cells around a central lumen forming a gland-like structure.[13]


References

  1. ↑ 1.0 1.1 Kumar, et al. (2005). The Central Nervous System. Pathologic Basis of Disease. 7th Edition. Philadelphia: Elsevier Saunders.
  2. ↑ Korshunov A, Golanov A, Timirgaz V (2000). "Immunohistochemical markers for intracranial ependymoma recurrence. An analysis of 88 cases". J Neurol Sci. 177 (1): 72–82. PMID 10967185.
  3. ↑ Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B; et al. (2006). "Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma". Clin Cancer Res. 12 (7 Pt 1): 2070–9. doi:10.1158/1078-0432.CCR-05-2363. PMID 16609018.
  4. ↑ Mohankumar KM, Currle DS, White E, Boulos N, Dapper J, Eden C; et al. (2015). "An in vivo screen identifies ependymoma oncogenes and tumor-suppressor genes". Nat Genet. 47 (8): 878–87. doi:10.1038/ng.3323. PMC 4520751. PMID 26075792.
  5. ↑ Abedalthagafi MS, Wu MP, Merrill PH, Du Z, Woo T, Sheu SH; et al. (2016). "Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours". J Pathol. 238 (4): 584–97. doi:10.1002/path.4682. PMC 5364032. PMID 26690880.
  6. ↑ Georgescu MM, Yell P, Mobley BC, Shang P, Georgescu T, Wang SH; et al. (2015). "NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma". Acta Neuropathol Commun. 3: 11. doi:10.1186/s40478-015-0197-z. PMC 4352254. PMID 25775275.
  7. ↑ Andreiuolo F, Le Teuff G, Bayar MA, Kilday JP, Pietsch T, von Bueren AO; et al. (2017). "Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification". PLoS One. 12 (6): e0178351. doi:10.1371/journal.pone.0178351. PMC 5472261. PMID 28617804.
  8. ↑ Araki A, Chocholous M, Gojo J, Dorfer C, Czech T, Heinzl H; et al. (2016). "Chromosome 1q gain and tenascin-C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma". Acta Neuropathol Commun. 4 (1): 88. doi:10.1186/s40478-016-0349-9. PMC 4994287. PMID 27550150.
  9. ↑ Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R; et al. (2012). "A prognostic gene expression signature in infratentorial ependymoma". Acta Neuropathol. 123 (5): 727–38. doi:10.1007/s00401-012-0941-4. PMC 4013829. PMID 22322993.
  10. ↑ Zakrzewska M, Fendler W, Zakrzewski K, Sikorska B, Grajkowska W, Dembowska-Bagińska B; et al. (2016). "Altered MicroRNA Expression Is Associated with Tumor Grade, Molecular Background and Outcome in Childhood Infratentorial Ependymoma". PLoS One. 11 (7): e0158464. doi:10.1371/journal.pone.0158464. PMC 4938415. PMID 27390862.
  11. ↑ EPENDYMOMA. http://librepathology.org/wiki/index.php/File:AFIP405713G-EPENDYMOMA.jpg 2015. URL Accessed on 10 6, 2015
  12. ↑ Ependymoma. https://en.wikipedia.org/wiki/Ependymoma#/media/File:Ependymoma_low_intermed_mag.jpg. URL Accessed on 10 6, 2015
  13. ↑ Image courtesy of Dr Dharam RamnaniRadiopaedia (original filehere). [1] CreativeCommons BY-SANC

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Ependymoma_pathophysiology&oldid=1582521"