Myeloproliferative neoplasm physical examination: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Myeloproliferative disease}} | {{Myeloproliferative disease}} | ||
{{CMG}} {{AE}} {{MJK}} | {{CMG}} {{AE}} {{MJK}} {{shyam}} | ||
==Overview== | ==Overview== | ||
Patients with myeloproliferative neoplasm are usually well-appearing. Physical examination of patients with chronic myelogenous leukemia is usually remarkable for skin [[bruising]] , [[fever]], [[splenomegaly]], and [[lymphadenopathy]]. | Patients with myeloproliferative neoplasm are usually well-appearing. Physical examination of patients with chronic myelogenous leukemia is usually remarkable for skin [[bruising]], [[fever]], [[splenomegaly]], and [[lymphadenopathy]]. | ||
==Physical Examination== | ==Physical Examination== | ||
Common physical examination findings associated with myeloproliferative neoplasm include: | Common physical examination findings associated with myeloproliferative neoplasm include:<ref name="pmid25810569">{{cite journal| author=Agarwal MB, Malhotra H, Chakrabarti P, Varma N, Mathews V, Bhattacharyya J et al.| title=Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia. | journal=Indian J Med Paediatr Oncol | year= 2015 | volume= 36 | issue= 1 | pages= 3-16 | pmid=25810569 | doi=10.4103/0971-5851.151770 | pmc=PMC4363847 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25810569 }} </ref><ref name="Tefferi">{{cite journal|title=Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era|author=Tefferi A|journal=Hematology Am Soc Hematol Educ Program|date=2006|pages=240-245|pmid=17124067}}</ref><ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/signs-and-symptoms/?region=ab</ref><ref name="pmid23049404">{{cite journal| author=Bittencourt RI, Vassallo J, Chauffaille Mde L, Xavier SG, Pagnano KB, Nascimento AC et al.| title=Philadelphia-negative chronic myeloproliferative neoplasms. | journal=Rev Bras Hematol Hemoter | year= 2012 | volume= 34 | issue= 2 | pages= 140-9 | pmid=23049404 | doi=10.5581/1516-8484.20120034 | pmc=PMC3459391 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23049404 }} </ref> | ||
===Appearance of the Patient=== | ===Appearance of the Patient=== | ||
*Patients are usually well-appearing | *Patients are usually well-appearing at an early time point in the disease and ill-appearing at a later time point in the disease. | ||
===Vital Signs=== | ===Vital Signs=== | ||
*[[Fever]] | *[[Fever]] | ||
*[[Tachycardia]] | |||
===Skin=== | ===Skin=== | ||
*[[ | *[[Ecchymoses]] | ||
*[[Petechiae]] | *[[Petechiae]] | ||
*[[Ulcers]] | *[[Ulcers]] | ||
*[[Vesicles]] | *[[Vesicles]] | ||
*[[Pallor]] | |||
===HEENT=== | ===HEENT=== | ||
*Decreased vision acuity | *Decreased vision acuity | ||
*Mucosal [[pallor]] | |||
===Neck=== | ===Neck=== | ||
*[[Lymphadenopathy]] | *[[Lymphadenopathy]] | ||
| Line 26: | Line 34: | ||
===Abdomen=== | ===Abdomen=== | ||
*[[Splenomegaly]] | *[[Splenomegaly]] | ||
*[[Hepatomegaly]] | |||
*Tenderness to palpation | |||
===Genitourinary=== | ===Genitourinary=== | ||
*[[lymphadenopathy|Inguinal lymphadenopathy]] (usually painless) | *[[lymphadenopathy|Inguinal lymphadenopathy]] (usually painless) | ||
*Scrotal swelling | *Scrotal swelling | ||
*[[Priapism]] | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Hematology | [[Category:Hematology]] | ||
[[Category: Disease]] | [[Category: Disease]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
Latest revision as of 15:26, 28 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2] Shyam Patel [3]
Overview
Patients with myeloproliferative neoplasm are usually well-appearing. Physical examination of patients with chronic myelogenous leukemia is usually remarkable for skin bruising, fever, splenomegaly, and lymphadenopathy.
Physical Examination
Common physical examination findings associated with myeloproliferative neoplasm include:[1][2][3][4]
Appearance of the Patient
- Patients are usually well-appearing at an early time point in the disease and ill-appearing at a later time point in the disease.
Vital Signs
Skin
HEENT
- Decreased vision acuity
- Mucosal pallor
Neck
Lungs
- Vesicular breath sounds
- Wheezing
Chest
- Axillary lymphadenopathy (usually painless)
Abdomen
- Splenomegaly
- Hepatomegaly
- Tenderness to palpation
Genitourinary
- Inguinal lymphadenopathy (usually painless)
- Scrotal swelling
- Priapism
References
- ↑ Agarwal MB, Malhotra H, Chakrabarti P, Varma N, Mathews V, Bhattacharyya J; et al. (2015). "Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia". Indian J Med Paediatr Oncol. 36 (1): 3–16. doi:10.4103/0971-5851.151770. PMC 4363847. PMID 25810569.
- ↑ Tefferi A (2006). "Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era". Hematology Am Soc Hematol Educ Program: 240–245. PMID 17124067.
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/signs-and-symptoms/?region=ab
- ↑ Bittencourt RI, Vassallo J, Chauffaille Mde L, Xavier SG, Pagnano KB, Nascimento AC; et al. (2012). "Philadelphia-negative chronic myeloproliferative neoplasms". Rev Bras Hematol Hemoter. 34 (2): 140–9. doi:10.5581/1516-8484.20120034. PMC 3459391. PMID 23049404.