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| __NOTOC__ | | __NOTOC__ |
| {{Chronic lymphocytic leukemia}} | | [[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Chronic_lymphocytic_leukemia]] |
| {{CMG}} {{AE}}{{HL}} | | {{CMG}} {{AE}}{{HL}} {{HK}} |
| ==Overview== | | ==Overview== |
| * Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
| | Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]]. |
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| ==Differenting Chronic lymphocytic leukemia from other Diseases== | | ==Differenting Chronic lymphocytic leukemia from other Diseases== |
| * Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], prolymphocytic leukaemia, [[follicular lymphoma]], and [[mantle cell lymphoma]].
| | Chronic lymphocytic leukemia must be differentiated from other diseases that cause [[weight loss]], [[night sweats]], [[hepatosplenomegaly]], and palpable [[lymph node]]s, such as [[hairy cell leukaemia]], [[Prolymphocytic leukemia|prolymphocytic leukaemia]], [[follicular lymphoma]], and [[mantle cell lymphoma]]. |
| * Based on the expression of cell surface markers, the table below differentiates chronic lymphocytic leukemia from other diseases that cause similar clinical presentations:<ref name="H">Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
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| <br>
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| {| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
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| |valign=top|
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| ! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''Surface Immunoglobulin'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD5'''}}
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| ! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|'''CD22/FMC7'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD23'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD79b'''}}
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| ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD103'''}}
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Chronic lymphocytic leukemia'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center |
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| '''Weakly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center |
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center |
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive/Negative'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Prolymphocytic leukemia'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Hairy cell leukemia'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive/Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Mantle cell lymphoma'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| |-
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| | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
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| '''Follicular lymphoma'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Strongly positive'''
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| | style="padding: 5px 5px; background: #F5F5F5;" align=center|
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| '''Negative'''
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| |}
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| <br>
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| * Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:<ref name="wiki">Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015</ref>
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| :* [[Splenic marginal zone lymphoma]]
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| :* Nodal marginal zone [[lymphoma]]
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| :* [[Lymphoplasmacytic lymphoma]]
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| :* [[Sézary syndrome]]
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| :* Smoldering [[adult T cell leukemia]]
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| ==References== | | ==References== |
| {{reflist|2}} | | {{reflist|2}} |
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| [[Category:Disease]]
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| [[Category:Hematology]]
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| [[Category:Mature chapter]]
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| {{Hematology}}
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| {{Hematological malignancy histology}}
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