Mesoblastic nephroma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
On gross pathology, a solid nonencapsulated [[mass]] that often occurs near the [[renal]] [[hilum]] is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, [[spindle cell]] is the characteristic finding of classic mesoblastic nephroma; whereas, plump [[cell]]s with vesicular [[nuclei]] is the characteristic finding of cellular mesoblastic nephroma.<ref>{{cite book | last = Humphrey | first = Peter | title = The Washington manual of surgical pathology | publisher = Lippincott Williams & Wilkins | location = Philadelphia | year = 2008 | isbn = 978-0781765275 }}</ref> | |||
==Genetics== | |||
* [[Translocation]] t(12:15)(p13;q25) that generates the fusion of [[ETV6]]/NTRK3 gene is involved in the pathogenesis of mesoblastic nephroma.<ref name="pmid9462753">{{cite journal | vauthors = Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH | title = A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma | journal = [[Nature Genetics]] | volume = 18 | issue = 2 | pages = 184–7 | year = 1998 | pmid = 9462753 | doi = 10.1038/ng0298-184 | url = | issn = }}</ref> | |||
==Gross Pathology== | |||
Characteristic findings of mesoblastic nephroma include:<ref name=radio> Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma </ref> | |||
* Solid nonencapsulated [[mass]] | |||
* Often occurs near the renal [[hilum]] | |||
* Tends to invade the surrounding structures and [[renal]] parenchyma | |||
* [[Hemorrhage]] and [[necrosis]] are infrequent | |||
==Microscopic Pathology== | |||
Classic mesoblastic nephroma<ref>{{cite book | last = Humphrey | first = Peter | title = The Washington manual of surgical pathology | publisher = Lippincott Williams & Wilkins | location = Philadelphia | year = 2008 | isbn = 978-0781765275 }}</ref> | |||
* [[Spindle cells]] in [[fascicles]] | |||
* Infiltrative border | |||
Cellular mesoblastic nephroma | |||
* Plump cells with vesicular nuclei | |||
* Well-defined border | |||
* Mitotically active | |||
Mixed mesoblastic nephroma | |||
* Both classic pattern and cellular pattern areas are present | |||
==References== | ==References== | ||
Latest revision as of 15:10, 17 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
On gross pathology, a solid nonencapsulated mass that often occurs near the renal hilum is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, spindle cell is the characteristic finding of classic mesoblastic nephroma; whereas, plump cells with vesicular nuclei is the characteristic finding of cellular mesoblastic nephroma.[1]
Genetics
- Translocation t(12:15)(p13;q25) that generates the fusion of ETV6/NTRK3 gene is involved in the pathogenesis of mesoblastic nephroma.[2]
Gross Pathology
Characteristic findings of mesoblastic nephroma include:[3]
- Solid nonencapsulated mass
- Often occurs near the renal hilum
- Tends to invade the surrounding structures and renal parenchyma
- Hemorrhage and necrosis are infrequent
Microscopic Pathology
Classic mesoblastic nephroma[4]
- Spindle cells in fascicles
- Infiltrative border
Cellular mesoblastic nephroma
- Plump cells with vesicular nuclei
- Well-defined border
- Mitotically active
Mixed mesoblastic nephroma
- Both classic pattern and cellular pattern areas are present
References
- ↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
- ↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.
- ↑ Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma
- ↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.