Essential thrombocytosis epidemiology and demographics: Difference between revisions

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{{Essential thrombocytosis}}
{{Essential thrombocytosis}}
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==Overview==Essential thrombocytosis is a rare idiopathic condition affecting about 24 for every million people in the world<ref>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref>. Although '''ET''' can present at any age, the disease usually affects middle aged to elderly individuals, with an average age at diagnosis being 50-70 years.<ref>Hoffman: Hematology: Basic Principles and Practice, 4th ed., 2005 Churchill Livingstone, Chapter 71.</ref>
==Overview==
The incidence of essential thrombocytosis is approximately 0.6-2.5 cases per 100,000 individuals worldwide annually.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref> The prevalence of essential thrombocytosis is about 30 for every 100,000 people worldwide.<ref name=fm>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref> The incidence of essential thrombocytosis increases with age; the median age at diagnosis is 65-70 years. Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.<ref name=gb>Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.</ref> Females are more commonly affected with essential thrombocytosis than males.<ref name=gb>Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.</ref> The female to male ratio is approximately 2 to 1.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref>


==Epidemiology==
==Epidemiology==
*Essential thrombocytosis is a rare idiopathic condition affecting about 24 for every million people in the world<ref>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref>. Although '''ET''' can present at any age, the disease usually affects middle aged to elderly individuals, with an average age at diagnosis being 50-70 years.<ref>Hoffman: Hematology: Basic Principles and Practice, 4th ed., 2005 Churchill Livingstone, Chapter 71.</ref>  
 
*ET has a bimodal presentation in that it presents in people in their 60's while the other peak occurs in the 30's.  
===Incidence===
*Females in their third decade of life are slightly affected more than the males at same age, the male to female ratio being 1.5-2:1. Patients in the 6th decade of life usually have same incidence in both males and females
*The annual incidence of essential thrombocytosis is estimated to be 0.6-2.5 cases per 100,000 individuals worldwide.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref>
*In reality, the incidence may be much more higher attributing the incidental diagnosis of the condition where many go undiagnosed due to lack of routine medical care.
 
===Prevalence===
*Worldwide, the prevalence of essential thrombocytosis is approximately 30 for every 100,000 individuals worldwide.<ref name=fm>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref>.
 
===Age===
*Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.<ref name=gb>Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.</ref>
*The median age at onset is 65-70 years.
 
===Gender===
*Women in their third decade of life are more commonly affected with essential thrombocytosis than men at same age. The female to male ratio is approximately 2:1.<ref name="pmid17210076">{{cite journal| author=Brière JB| title=Essential thrombocythemia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 3 | pmid=17210076 | doi=10.1186/1750-1172-2-3 | pmc=PMC1781427 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17210076  }} </ref>
*Patients who present in the 6th decade of life usually have same incidence in both men and women.


==References==
==References==

Latest revision as of 15:51, 6 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

The incidence of essential thrombocytosis is approximately 0.6-2.5 cases per 100,000 individuals worldwide annually.[1] The prevalence of essential thrombocytosis is about 30 for every 100,000 people worldwide.[2] The incidence of essential thrombocytosis increases with age; the median age at diagnosis is 65-70 years. Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.[3] Females are more commonly affected with essential thrombocytosis than males.[3] The female to male ratio is approximately 2 to 1.[1]

Epidemiology

Incidence

  • The annual incidence of essential thrombocytosis is estimated to be 0.6-2.5 cases per 100,000 individuals worldwide.[1]
  • In reality, the incidence may be much more higher attributing the incidental diagnosis of the condition where many go undiagnosed due to lack of routine medical care.

Prevalence

  • Worldwide, the prevalence of essential thrombocytosis is approximately 30 for every 100,000 individuals worldwide.[2].

Age

  • Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.[3]
  • The median age at onset is 65-70 years.

Gender

  • Women in their third decade of life are more commonly affected with essential thrombocytosis than men at same age. The female to male ratio is approximately 2:1.[4]
  • Patients who present in the 6th decade of life usually have same incidence in both men and women.

References

  1. ↑ 1.0 1.1 1.2 Fabris F, Randi ML (2009). "Essential thrombocythemia: past and present". Intern Emerg Med. 4 (5): 381–8. doi:10.1007/s11739-009-0284-x. PMID 19636672.
  2. ↑ 2.0 2.1 Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015
  3. ↑ 3.0 3.1 3.2 Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.
  4. ↑ Brière JB (2007). "Essential thrombocythemia". Orphanet J Rare Dis. 2: 3. doi:10.1186/1750-1172-2-3. PMC 1781427. PMID 17210076.


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