Essential thrombocytosis epidemiology and demographics: Difference between revisions

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==Overview==
==Overview==
The incidence of Essential thrombocytosis was estimated to be 0.6-2.5 cases per 100,000 individuals worldwide annually.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref> Though in reality the number may be much more higher attributing the incidental diagnosis of the condition where many go undiagnosed due to lack of routine medical care. The median age at onset is 65-70 years. Worldwide, the prevalence of Essential thrombocytosis is about 24 for every million people in the world.<ref>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref> The disease shows a slight female preponderance in the elderly patients while the incidence remains the same in patients who present with ET in their 3rd decade of life.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref>  
The incidence of essential thrombocytosis is approximately 0.6-2.5 cases per 100,000 individuals worldwide annually.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref> The prevalence of essential thrombocytosis is about 30 for every 100,000 people worldwide.<ref name=fm>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref> The incidence of essential thrombocytosis increases with age; the median age at diagnosis is 65-70 years. Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.<ref name=gb>Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.</ref> Females are more commonly affected with essential thrombocytosis than males.<ref name=gb>Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.</ref> The female to male ratio is approximately 2 to 1.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref>


==Epidemiology==
==Epidemiology==


===Incidence===
===Incidence===
*The incidence of Essential thrombocytosis was estimated to be 0.6-2.5 cases per 100,000 individuals worldwide annually.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref>
*The annual incidence of essential thrombocytosis is estimated to be 0.6-2.5 cases per 100,000 individuals worldwide.<ref name="pmid19636672">{{cite journal| author=Fabris F, Randi ML| title=Essential thrombocythemia: past and present. | journal=Intern Emerg Med | year= 2009 | volume= 4 | issue= 5 | pages= 381-8 | pmid=19636672 | doi=10.1007/s11739-009-0284-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19636672  }} </ref>
*In reality the incidence may be much more higher attributing the incidental diagnosis of the condition where many go undiagnosed due to lack of routine medical care.  
*In reality, the incidence may be much more higher attributing the incidental diagnosis of the condition where many go undiagnosed due to lack of routine medical care.  


===Prevalence===
===Prevalence===
*Worldwide, the prevalence of Essential thrombocytosis is about 24 for every million people in the world.<ref>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref>.
*Worldwide, the prevalence of essential thrombocytosis is approximately 30 for every 100,000 individuals worldwide.<ref name=fm>Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015</ref>.


===Age===
===Age===
*ET is usually first diagnosed in the late 50's or early 60's.
*Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.<ref name=gb>Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.</ref>
*ET has a bimodal presentation in that it presents in people in their 60's while the other peak occurs in the 30's.
*The median age at onset is 65-70 years.
*The median age at onset is 65-70 years.


===Gender===
===Gender===
*Women in their third decade of life are more commonly affected with Essential thrombocytosis than men at same age. The male to female ratio is approximately 1:1.5-2
*Women in their third decade of life are more commonly affected with essential thrombocytosis than men at same age. The female to male ratio is approximately 2:1.<ref name="pmid17210076">{{cite journal| author=Brière JB| title=Essential thrombocythemia. | journal=Orphanet J Rare Dis | year= 2007 | volume= 2 | issue=  | pages= 3 | pmid=17210076 | doi=10.1186/1750-1172-2-3 | pmc=PMC1781427 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17210076  }} </ref>
*Patients in the 6th decade of life usually have same incidence in both men and women.
*Patients who present in the 6th decade of life usually have same incidence in both men and women.


==References==
==References==

Latest revision as of 15:51, 6 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

The incidence of essential thrombocytosis is approximately 0.6-2.5 cases per 100,000 individuals worldwide annually.[1] The prevalence of essential thrombocytosis is about 30 for every 100,000 people worldwide.[2] The incidence of essential thrombocytosis increases with age; the median age at diagnosis is 65-70 years. Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.[3] Females are more commonly affected with essential thrombocytosis than males.[3] The female to male ratio is approximately 2 to 1.[1]

Epidemiology

Incidence

  • The annual incidence of essential thrombocytosis is estimated to be 0.6-2.5 cases per 100,000 individuals worldwide.[1]
  • In reality, the incidence may be much more higher attributing the incidental diagnosis of the condition where many go undiagnosed due to lack of routine medical care.

Prevalence

  • Worldwide, the prevalence of essential thrombocytosis is approximately 30 for every 100,000 individuals worldwide.[2].

Age

  • Patients of all age groups may develop essential thrombocytosis. However it commonly affects individuals older than 60 years of age.[3]
  • The median age at onset is 65-70 years.

Gender

  • Women in their third decade of life are more commonly affected with essential thrombocytosis than men at same age. The female to male ratio is approximately 2:1.[4]
  • Patients who present in the 6th decade of life usually have same incidence in both men and women.

References

  1. ↑ 1.0 1.1 1.2 Fabris F, Randi ML (2009). "Essential thrombocythemia: past and present". Intern Emerg Med. 4 (5): 381–8. doi:10.1007/s11739-009-0284-x. PMID 19636672.
  2. ↑ 2.0 2.1 Essential Thrombocythemia. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/essential-thrombocythemia. Accessed on October 29, 2015
  3. ↑ 3.0 3.1 3.2 Essential Thrombocythemia (ET). MPN Research foundation. http://www.mpnresearchfoundation.org/Essential-Thrombocythemia Accessed on November 15, 2015.
  4. ↑ Brière JB (2007). "Essential thrombocythemia". Orphanet J Rare Dis. 2: 3. doi:10.1186/1750-1172-2-3. PMC 1781427. PMID 17210076.


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