Gestational trophoblastic neoplasia laboratory findings: Difference between revisions
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* Elevated hPL levels are found in women with some types of GTD | * Elevated hPL levels are found in women with some types of GTD | ||
===Complete blood count=== | ===Complete blood count=== | ||
* [[Complete blood count]] can check for [[anemia ]] from long-term (chronic) [[vaginal bleeding]] | * [[Complete blood count]] can check for [[anemia ]] from long-term (chronic) [[vaginal bleeding]] | ||
===Kidney function tests=== | ===Kidney function tests=== | ||
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Latest revision as of 23:36, 26 November 2017
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Gestational trophoblastic neoplasia Microchapters |
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Differentiating Gestational trophoblastic neoplasia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overview
Elevated serum human chorionic gonadotropin is diagnostic of choriocarcinoma.[1][2]
Laboratory Findings
Quantitative serum HCG
- Human chorionic gonadotropin (HCG or b-HCG) is the most common tumor marker test used to diagnose GTD[1]
- HCG is markedly elevated (usu. >10,000 IU)[2]
- HCG is a very sensitive test for diagnosing most gestational trophoblastic tumors
- HCG is usually measured in the blood, but it can also be measured in the urine
- HCG levels are much higher in women with complete hydatidiform moles and gestational choriocarcinoma compared to HCG levels in women with a normal pregnancy
- With partial moles, the HCG level is higher than normal, but it is not as high as with other types of GTD
- With placental site tumors, the HCG level may be slightly higher than normal, but it is not considered a good marker for this type of tumor
- An HCG test can help find GTD after pregnancy or miscarriage as this hormone should not be present in the blood or urine soon afterward
Human placental lactogen (hPL)
- Human placental lactogen (hPL) is a tumor marker that may be used to follow women with placental site trophoblastic tumors
- Elevated hPL levels are found in women with some types of GTD
Complete blood count
- Complete blood count can check for anemia from long-term (chronic) vaginal bleeding
Kidney function tests
Liver function tests
References
- ↑ 1.0 1.1 Diagnosing gestational trophoblastic disease. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/gestational-trophoblastic-disease/diagnosis/?region=ns Accessed on October 13, 2015
- ↑ 2.0 2.1 Choriocarcinoma. librepathology.org. http://librepathology.org/wiki/index.php/Choriocarcinoma Accessed on October 8, 2015