Polycythemia vera history and symptoms: Difference between revisions

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{{Polycythemia vera}}
{{Polycythemia vera}}
{{CMG}}{{AE}}{{MJK}}
{{CMG}} {{AE}} {{IO}} {{MJK}}; {{shyam}}
==Overview==
==Overview==
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]].<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/polycythemia-vera/?region=ab</ref>
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]] especially after exposure to warm water, loss of concentration and [[night sweats]] and neurological symptoms.  
==History and Symptoms==
==History and Symptoms==  
Symptoms of polycythemia vera may include:<ref name="cancer.ca">Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/polycythemia-vera/?region=ab</ref><ref>{{cite journal | author = Steinman H, Kobza-Black A, Lotti T, Brunetti L, Panconesi E, Greaves M | title = Polycythaemia rubra vera and water-induced pruritus: blood histamine levels and cutaneous fibrinolytic activity before and after water challenge. | journal = Br J Dermatol | volume = 116 | issue = 3 | pages = 329-33 | year = 1987 | id = PMID 3567071}}</ref><ref>{{cite journal | author = Jackson N, Burt D, Crocker J, Boughton B | title = Skin mast cells in polycythaemia vera: relationship to the pathogenesis and treatment of pruritus. | journal = Br J Dermatol | volume = 116 | issue = 1 | pages = 21-9 | year = 1987 | id = PMID 3814512}}</ref><ref>{{cite journal | author = Fjellner B, Hägermark O | title = Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement. | journal = Acta Derm Venereol | volume = 59 | issue = 6 | pages = 505-12 | year = 1979 | id = PMID 94209}}</ref><ref>{{cite journal | author = Torgano G, Mandelli C, Massaro P, Abbiati C, Ponzetto A, Bertinieri G, Bogetto S, Terruzzi E, de Franchis R | title = Gastroduodenal lesions in polycythaemia vera: frequency and role of Helicobacter pylori. | journal = Br J Haematol | volume = 117 | issue = 1 | pages = 198-202 | year = 2002 | id = PMID 11918555}}</ref><ref>{{cite journal | author = van Genderen P, Michiels J | title = Erythromelalgia: a pathognomonic microvascular thrombotic complication in essential thrombocythemia and polycythemia vera. | journal = Semin Thromb Hemost | volume = 23 | issue = 4 | pages = 357-63 | year = 1997 | id = PMID 9263352}}</ref><ref>{{cite journal | author = Michiels J | title = Erythromelalgia and vascular complications in polycythemia vera. | journal = Semin Thromb Hemost | volume = 23 | issue = 5 | pages = 441-54 | year = 1997 | id = PMID 9387203}}</ref><ref>{{cite journal | author = Landolfi R, Ciabattoni G, Patrignani P, Castellana M, Pogliani E, Bizzi B, Patrono C | title = Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo. | journal = Blood | volume = 80 | issue = 8 | pages = 1965-71 | year = 1992 | id = PMID 1327286}}</ref>
===History===
Patients with polycythemia vera may have a positive history of:<ref name="Tefferi2002">{{cite journal|last1=Tefferi|first1=A.|title=Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus|journal=Blood|volume=99|issue=7|year=2002|pages=2627–2627|issn=00064971|doi=10.1182/blood.V99.7.2627}}</ref>
*[[Pruritus]]
*[[Fatigue]]
*[[Headache]]
*[[Headache]]
*[[Pruritis]]
*[[Early satiety]]
:*Increase after exposure to warm water
 
:*Due to [[histamine]] release or [[prostaglandin]] production
===Common Symptoms===
:*Present in approximately 40% of patients
Common symptoms of polycythemia vera include:<ref name="Tefferi2002">{{cite journal|last1=Tefferi|first1=A.|title=Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus|journal=Blood|volume=99|issue=7|year=2002|pages=2627–2627|issn=00064971|doi=10.1182/blood.V99.7.2627}}</ref><ref name="pmid19468728">{{cite journal |vauthors=Cario H, McMullin MF, Pahl HL |title=Clinical and hematological presentation of children and adolescents with polycythemia vera |journal=Ann. Hematol. |volume=88 |issue=8 |pages=713–9 |date=August 2009 |pmid=19468728 |pmc=4135082 |doi=10.1007/s00277-009-0758-y |url=}}</ref><ref name="pmid20597963">{{cite journal |vauthors=Saini KS, Patnaik MM, Tefferi A |title=Polycythemia vera-associated pruritus and its management |journal=Eur. J. Clin. Invest. |volume=40 |issue=9 |pages=828–34 |date=September 2010 |pmid=20597963 |doi=10.1111/j.1365-2362.2010.02334.x |url=}}</ref>
*[[Tinnitis]]
*[[Blurred vision]]
*[[Malaise]]
*[[Loss of appetite]]
*[[Weight loss]]
*[[Shortness of breath]]
*[[Fatigue]]
*[[Fatigue]]
*[[Dizziness]]
*[[Headache]]
*[[Bleeding]]
*[[Pruritus]]
:*[[Bruising]]
**Especially after exposure to warm water
:*[[Epistaxis]]
**May be related to [[serotonin]] release by [[Platelet|platelets]] as well as elevated [[histamine]] levels
:*[[Bleeding gums]]  
*Abdominal pain
:*[[Menorrhagia]]
*Loss of concentration
:*[[Metrorrhagia]]
*[[Night sweats]]  
:*[[Petechiae]]
*Sexual problems
*[[Chest pain]]
*[[Insomnia]]
*[[Arthralgia]]
*Decreased mood
*[[Numbness]]
*[[Early satiety]]  
*[[Dizziness]]  
*[[Cough]]  
*[[Erythromelalgia]]
*[[Erythromelalgia]]
*[[Heart burn]]
*[[Weakness]]
:* Due to increased susceptibility to infection with [[Helicobacter pylori|H. pylori]]
 
===Less Common Symptoms===
Less common symptoms of polycythemia vera include:<ref name="pmid26324368">{{cite journal |vauthors=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R |title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F |journal=J. Clin. Oncol. |volume=33 |issue=33 |pages=3953–60 |date=November 2015 |pmid=26324368 |pmc=4979103 |doi=10.1200/JCO.2015.61.6474 |url=}}</ref>
*[[Fever]]
*Weight loss
*Sweating
*Visual disturbances
*[[Parasthesias|Paresthesia]]
*[[Dyspnea]]
*Bone pains


==References==
==References==
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Latest revision as of 03:06, 14 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2] Mohamad Alkateb, MBBCh [3]; Shyam Patel [4]

Overview

People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include headache, fatigue, and pruritis especially after exposure to warm water, loss of concentration and night sweats and neurological symptoms.

History and Symptoms

History

Patients with polycythemia vera may have a positive history of:[1]

Common Symptoms

Common symptoms of polycythemia vera include:[1][2][3]

Less Common Symptoms

Less common symptoms of polycythemia vera include:[4]

References

  1. ↑ 1.0 1.1 Tefferi, A. (2002). "Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus". Blood. 99 (7): 2627–2627. doi:10.1182/blood.V99.7.2627. ISSN 0006-4971.
  2. ↑ Cario H, McMullin MF, Pahl HL (August 2009). "Clinical and hematological presentation of children and adolescents with polycythemia vera". Ann. Hematol. 88 (8): 713–9. doi:10.1007/s00277-009-0758-y. PMC 4135082. PMID 19468728.
  3. ↑ Saini KS, Patnaik MM, Tefferi A (September 2010). "Polycythemia vera-associated pruritus and its management". Eur. J. Clin. Invest. 40 (9): 828–34. doi:10.1111/j.1365-2362.2010.02334.x. PMID 20597963.
  4. ↑ Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R (November 2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J. Clin. Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.

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