Metanephric adenoma pathophysiology: Difference between revisions
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{{CMG}}; {{AE}} {{SC}} | {{CMG}}; {{AE}} {{SC}} | ||
==Overview== | ==Overview== | ||
On gross pathology, a sharply circumscribed, nonencapsulated solitary [[mass]] is the characteristic finding of metanephric adenoma. On microscopic histopathological analysis, small uniform cells with fine [[chromatin]] and smooth [[nuclear membrane]], variable architecture, and [[Psammoma body|psammoma bodies]] are characteristic findings of metanephric adenoma. <ref>Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015 </ref> | |||
==Genetics== | |||
* Allelic changes of a [[tumor suppressor gene]] on [[chromosome]] 2p13 may be involved in the pathogenesis of metanephric adenoma.<ref name="pmid11172302">{{cite journal |vauthors=Pesti T, Sükösd F, Jones EC, Kovacs G |title=Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping |journal=[[Human Pathology]] |volume=32 |issue=1 |pages=101–4 |year=2001 |pmid=11172302 |doi=10.1053/hupa.2001.21132 |url=http://linkinghub.elsevier.com/retrieve/pii/S0046-8177(01)63640-2 |issn=}}</ref> | |||
==Gross Pathology== | ==Gross Pathology== | ||
| Line 11: | Line 15: | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
The characteristics of metanephric adenomas include: | The characteristics of metanephric adenomas include:<ref>Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015 </ref> | ||
* Small uniform cells with: | * Small uniform cells with: | ||
:* Fine chromatin | :* Fine chromatin | ||
:* No apparent nucleolus | :* No apparent [[nucleolus]] | ||
:* Smooth nuclear membrane | :* Smooth [[nuclear membrane]] | ||
* Variable architecture: | * Variable architecture: | ||
:* May be sheets, ductal or micropapillary | :* May be sheets, ductal or micropapillary | ||
* Psammoma bodies may present | * [[Psammoma body|Psammoma bodies]] may be present | ||
<gallery> | <gallery> | ||
Image: | Image: | ||
Metanephric adenoma1.jpg|Metanephric adenoma<ref>Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015 </ref> | |||
</gallery> | </gallery> | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Latest revision as of 15:08, 17 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
On gross pathology, a sharply circumscribed, nonencapsulated solitary mass is the characteristic finding of metanephric adenoma. On microscopic histopathological analysis, small uniform cells with fine chromatin and smooth nuclear membrane, variable architecture, and psammoma bodies are characteristic findings of metanephric adenoma. [1]
Genetics
- Allelic changes of a tumor suppressor gene on chromosome 2p13 may be involved in the pathogenesis of metanephric adenoma.[2]
Gross Pathology
Characteristic findings of metanephric adenoma on gross pathology include:[3]
- Solitary mass
- Sharply circumscribed
- Not encapsulated
Microscopic Pathology
The characteristics of metanephric adenomas include:[4]
- Small uniform cells with:
- Fine chromatin
- No apparent nucleolus
- Smooth nuclear membrane
- Variable architecture:
- May be sheets, ductal or micropapillary
- Psammoma bodies may be present
-
![Metanephric adenoma[5]](/images/b/b2/Metanephric_adenoma1.jpg)
Metanephric adenoma[5]
![Metanephric adenoma[5]](/index.php/File:Metanephric_adenoma1.jpg)
References
- ↑ Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015
- ↑ Pesti T, Sükösd F, Jones EC, Kovacs G (2001). "Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping". Human Pathology. 32 (1): 101–4. doi:10.1053/hupa.2001.21132. PMID 11172302.
- ↑ Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015
- ↑ Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015
- ↑ Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015