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==Overview==
==Overview==
Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis<ref name="pmidhttp://dx.doi.org/10.1182/blood-2007-04-083501">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1182/blood-2007-04-083501 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> as per [[WHO]] definition. The bone marrow biopsy shows hypercellularity with clusters of megakaryocytes that stain positive for iron. There may be increased reticulin but no [[collagen]] fibrosis.
Bone marrow [[biopsy]] is an important test and needed to make a diagnosis of essential thrombocytosis.<ref name="pmid16879015">{{cite journal| author=Sanchez S, Ewton A| title=Essential thrombocythemia: a review of diagnostic and pathologic features. | journal=Arch Pathol Lab Med | year= 2006 | volume= 130 | issue= 8 | pages= 1144-50 | pmid=16879015 | doi=10.1043/1543-2165(2006)130[1144:ET]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16879015 }} </ref> On bone marrow [[biopsy]], essential thrombocytosis is characterized by bone marrow hypercellularity with clusters of megakaryocytes that stain positive for iron, increased reticulin, and no [[collagen]] fibrosis.


==Bone marrow biopsy findings==  
==Bone marrow biopsy findings==  
Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis<ref name="pmidhttp://dx.doi.org/10.1182/blood-2007-04-083501">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1182/blood-2007-04-083501 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> as per WHO definition. The following changes may be seen on a bone marrow biopsy specimen:
*Bone marrow [[biopsy]] is an important test and needed to make a diagnosis of essential thrombocytosis.<ref name="pmid16879015">{{cite journal| author=Sanchez S, Ewton A| title=Essential thrombocythemia: a review of diagnostic and pathologic features. | journal=Arch Pathol Lab Med | year= 2006 | volume= 130 | issue= 8 | pages= 1144-50 | pmid=16879015 | doi=10.1043/1543-2165(2006)130[1144:ET]2.0.CO;2 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16879015 }} </ref>  
*Increased cellularity
*On bone marrow [[biopsy]], essential thrombocytosis is characterized by:  
*Hyperplasia and clustering of megakaryocytes
**Increased cellularity
*Bone marrow stains positive for iron
**Hyperplasia and clustering of megakaryocytes
*Bone marrow [[reticulin]] may be increased with no [[collagen]] fibrosis
**Bone marrow stains positive for iron
**Bone marrow [[reticulin]] may be increased with no [[collagen]] fibrosis


==References==
==References==

Latest revision as of 19:48, 6 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis.[1] On bone marrow biopsy, essential thrombocytosis is characterized by bone marrow hypercellularity with clusters of megakaryocytes that stain positive for iron, increased reticulin, and no collagen fibrosis.

Bone marrow biopsy findings

  • Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis.[1]
  • On bone marrow biopsy, essential thrombocytosis is characterized by:
    • Increased cellularity
    • Hyperplasia and clustering of megakaryocytes
    • Bone marrow stains positive for iron
    • Bone marrow reticulin may be increased with no collagen fibrosis

References

  1. 1.0 1.1 Sanchez S, Ewton A (2006). "Essential thrombocythemia: a review of diagnostic and pathologic features". Arch Pathol Lab Med. 130 (8): 1144–50. doi:10.1043/1543-2165(2006)130[1144:ET]2.0.CO;2. PMID 16879015.


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