Sandbox: Bone DDx: Difference between revisions

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* 30-50 yo patients
* 55-60 yo males
* Unerupted teeth
* Back pain
* Oral ulcers
* Pathological fracture
* Palpable vertebral mass


* Painless mandibular mass
* Lower jaw crepitus on palpation
* Facial deformity


* Discrete, solitary mass male 55 years
* Pain at the site of the skeletal lesion
* Bone destruction


* Tall columnar cells with a palisaded nuclei and reverse polarization
* Well-defined, “punched-out” lytic lesions
* Subnuclear vacuolization
* Marked erosion, expansion, and destruction of bone cortex
* Giant cells
* Thick ridging around the periphery
* Subepithelial hyalinization
* “Soap bubble” appearance
 
 
* BRAF V600E mutations

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance