Sandbox: Bone DDx: Difference between revisions

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* <20 yo males
* 55-60 yo males
* Joint pain, muscle wasting, tenderness, and swelling/local mass
* Back pain
* Pathological fracture
* Well defined lucent lesions located at the epiphysis
* Palpable vertebral mass
* Lobulated margins with a thin sclerotic rim
* Internal calcifications
* Joint effusion


* Abundant extracellular material
* Eosinophilic cytoplasm
* Calcifications surround cells nests
* Chickenwire appearance


* S100+ve
* Discrete, solitary mass male 55 years
* Vimentin +ve
* Pain at the site of the skeletal lesion
* Bone destruction
 
* Well-defined, “punched-out” lytic lesions
* Marked erosion, expansion, and destruction of bone cortex
* Thick ridging around the periphery
* “Soap bubble” appearance

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance
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