Sandbox: Bone DDx: Difference between revisions

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* 10-20 yo males
* 55-60 yo males
* Extreme bone pain  
* Back pain
* Intermittent fever
* Pathological fracture
* Palpable vertebral mass


* Localized tenderness and swelling


* Anemia and leukocytosis
* Discrete, solitary mass male 55 years
* Increased sedimentation rate
* Pain at the site of the skeletal lesion
* Bone destruction


* Destructive bone lesions  
* Well-defined, “punched-out” lytic lesions
* "Onion-skin" periosteal reaction
* Marked erosion, expansion, and destruction of bone cortex
 
* Thick ridging around the periphery
 
* “Soap bubble” appearance
* Sheets of round, uniform, PAS +ve, small cells with a scant clear cytoplasm
* Round nuclei with indentations
* Homer-Wright rosettes
* Necrosis and hemorrhage
* Prominent vasculature and variable mitotic figures
 
* EWS/FLI-1 fusion gene
* t(11;22)(q24;q12)
* CD99 +ve
* FLI-1 +ve

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance
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