Sandbox: Bone DDx: Difference between revisions

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* 55-60 yo males
* Back pain
* Pathological fracture
* Palpable vertebral mass


* 30-60 yo males
* Bone pain, progressive swelling, decreased range of motion
* Pathologic fracture
* Positive history of radiation exposure or bone infarct


* Fixed, firm mass to a localized area of tenderness
* Discrete, solitary mass male 55 years
* Neurologic or vascular defect
* Pain at the site of the skeletal lesion
* Bone destruction


* Highly destructive with a wide zone of transition
* Well-defined, “punched-out” lytic lesions
* Expansile large soft tissue mass extending from the bone
* Marked erosion, expansion, and destruction of bone cortex
* Periosteal reaction is uncommon
* Thick ridging around the periphery
 
* “Soap bubble” appearance
* Elevated mitotic activity
* Highly cellular fibroblastic proliferation
* Herring bone pattern and spindle cell lesions
* Long dark nuclei with increased granular chromatin
* Scant cytoplasm
 
* Vimentin +ve

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance
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