Sandbox: Bone DDx: Difference between revisions

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* 10-20 yo patients
* 55-60 yo males
* Asymptomatic incidental finding on imaging studies
* Back pain
* Pathological fracture
* Palpable vertebral mass


* Facial asymmetry, rib deformities, and leg-length discrepancy as late complication


* Located at the craniofacial bones, ribs, and proximal femur
* Discrete, solitary mass male 55 years
* Pain at the site of the skeletal lesion
* Bone destruction


* Ground-glass matrix
* Well-defined, “punched-out” lytic lesions
* Completely lucent or bubbly cystic expansile benign lesion
* Marked erosion, expansion, and destruction of bone cortex
* Well circumscribed with no periosteal reaction
* Thick ridging around the periphery
 
* “Soap bubble” appearance
* Fibrocellular matrix of immature collagen
* Contains small irregularly shaped trabeculae of woven bone
* "Chinese characters" appearance  
* Trabeculae not rimmed by osteoblasts
* Cartilaginous islands
 
* GNAS1 gene 10

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance
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