Parathyroid cancer (patient information): Difference between revisions

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{{Parathyroid cancer (patient information)}}
{{Parathyroid cancer (patient information)}}
'''For the WikiDoc page for this topic, click [[Parathyroid cancer|here]].'''
'''For the WikiDoc page for this topic, click [[Parathyroid cancer|here]].'''
{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
==Overview==
* Multiple endocrine neoplasia (MEN) type II is a [[disease]] passed down through families, in which one or more of the [[endocrine gland]]s are overactive or form a [[tumor]]. [[Endocrine gland]]s most commonly involved include [[adrenal]] gland, [[parathyroid]] gland and [[thyroid]] gland.
* Parathyroid cancer is a rare disorder. The cause of parathyroid cancer has not been identified. The most common symptoms of parathyroid cancer include [[anorexia|weight loss]], [[muscle weakness]], [[fractures]], [[constipation]], [[fatigue]], and [[bone pain]].


==What are the symptoms of parathyroid cancer?==
==What are the symptoms of parathyroid cancer?==
Symptoms of parathyroid cancer are mainly caused by a high level of calcium in the blood (hypercalcemia), and may affect different parts of the body. They include:
* Symptoms of parathyroid cancer are mainly caused by a high level of [[calcium]] in the blood ([[hypercalcemia]]), and may affect different parts of the body. They include:
 
:* [[Bone pain]]
Bone pain
:* [[Constipation]]
Constipation
:* [[Fatigue]]
Fatigue
:* [[Fractures]]
Fractures
:* Frequent thirst
Frequent thirst
:* Frequent urination
Frequent urination
:* [[Kidney stones]]
Kidney stones
:* [[Muscle weakness]]
Muscle weakness
:* [[Nausea]]
Nausea
:* [[Poor appetite]]
Poor appetite
:* [[Vomiting]]
Vomiting


==What causes parathyroid cancer?==
==What causes parathyroid cancer?==
* Multiple endocrine neoplasia type 2 is an inherited disorder that causes [[tumor]]s in the [[endocrine gland]]s. Genetic [[mutation]]s of ''RET'' gene is speculated to be the cause of the [[disease]].
* The cause of parathyroid cancer has not been identified.


==Who is at highest risk?==
==Who is at highest risk?==
* Positive [[family history]]
* Positive [[family history]] of the following:
* Multifocal or recurrent [[neoplasia]]
:* [[Multiple endocrine neoplasia type 1]]
* Two or more organ systems [[tumor]] involvement
:* [[Hyperparathyroidism]]–jaw tumour syndrome
:* Familial isolated [[hyperparathyroidism]]


==Diagnosis==
==Diagnosis==
* Multiple endocrine neoplasia type 2 is detected by [[gene]] testing or, when [[gene]] testing is unavailable or yields a negative result, by laboratory tests that measure [[hormone]] levels.  Less often, multiple endocrine neoplasia type 2 is diagnosed based on an individual's medical and [[family history]].
* The following tests may be used to diagnose parathyroid cancer
:* Blood [[calcium]]
:* Blood [[parathyroid hormone]]


==When to seek urgent medical care?==
==When to seek urgent medical care?==
[https://www.google.com/maps/place/Danbury+Hospital/@41.4046542,-73.4483731,17z/data=!3m1!4b1!4m2!3m1!1s0x89e7ff3a0019a5cd:0x9cbfe6a6a525bdfa?hl=en Directions to Hospitals Treating Thyroid adenoma]
[https://www.google.com/maps/place/Danbury+Hospital/@41.4046542,-73.4483731,17z/data=!3m1!4b1!4m2!3m1!1s0x89e7ff3a0019a5cd:0x9cbfe6a6a525bdfa?hl=en Directions to Hospitals Treating Parathyroid Cancer]


==Treatment options==
==Treatment options==
* Multiple endocrine neoplasia type 2 cannot be cured, but regular testing can detect the problems caused by multiple endocrine neoplasia type 2. [[Tumor]]s may grow for many years before serious complications develop. 
* Treatment of parathyroid cancer includes:
* [[Surgery]] is indicated for [[thyroid tumor]]s, [[adrenal tumor]]s and [[parathyroid]] [[tumor]]s.
:* [[Intravenous (IV) fluid]]s
 
:* [[Diuretics]]
==Where to find medical care for multiple endocrine neoplasia type 2?==
:* Antiresorptive agents such as [[biphosphonates]], [[gallium]], or [[mithramycin]]  
[http://maps.google.com/maps?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|map+top+hospital+Multiple endocrine neoplasia type 1}}}}&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=wl Directions to Hospitals Treating Multiple endocrine neoplasia type 1]
* Calcimimetic agents that directly block secretion of the [[parathyroid hormone]] from the [[gland]]  
:* [[Gallium nitrate]] is used to reduce the [[calcium level]].
:* [[Calcitonin]] is used to control the calcium levels.
* [[Surgery]]
* [[Radiation therapy]]
* [[Chemotherapy]]


==Prevention==
==Where to find medical care for parathyroid cancer?==
* [[Screening]] people with [[family history]] of multiple endocrine neoplasia type 2 is recommended.
[http://maps.google.com/maps?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|map+top+hospital+Multiple endocrine neoplasia type 1}}}}&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=wl Directions to Hospitals Treating Parathyroid Cancer]


==What to expect (Outlook/Prognosis)?==
==What to expect (Outlook/Prognosis)?==
* [[Prognosis]] of the [[disease]] depends on the stage at which it is diagnosed. Early [[diagnosis]] and treatment is associated with better [[prognosis]].
* [[Prognosis]] of the [[parathyroid cancer]] depends on the stage at which it is diagnosed. Early [[diagnosis]] and treatment is associated with better [[prognosis]].


==Possible complications==
==Possible complications==
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* [[Fracture]]s
* [[Fracture]]s
* [[Hypoparathyroidism]] from parathyroidectomy
* [[Hypoparathyroidism]] from parathyroidectomy
==Sources==
==Sources==
* https://www.nlm.nih.gov/medlineplus/ency/article/000399.htm
* https://www.nlm.nih.gov/medlineplus/ency/article/000399.htm

Latest revision as of 19:57, 29 December 2015

Parathyroid cancer

Overview

What are the symptoms?

What are the causes?

Who is at highest risk?

Diagnosis

When to seek urgent medical care?

Treatment options

Where to find medical care for parathyroid cancer?

What to expect (Outlook/Prognosis)?

Possible complications

Parathyroid cancer On the Web

Ongoing Trials at Clinical Trials.gov

Images of Multiple endocrine neoplasia type 2

Videos on Parathyroid cancer

FDA on parathyroid cancer

CDC on parathyroid cancer

parathyroid cancer in the news

Blogs on parathyroid cancer

Directions to Hospitals Treating Parathyroid cancer

Risk calculators and risk factors for Multiple endocrine neoplasia type 2


Template:WikiDoc Sources For the WikiDoc page for this topic, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

What are the symptoms of parathyroid cancer?

  • Symptoms of parathyroid cancer are mainly caused by a high level of calcium in the blood (hypercalcemia), and may affect different parts of the body. They include:

What causes parathyroid cancer?

  • The cause of parathyroid cancer has not been identified.

Who is at highest risk?

Diagnosis

  • The following tests may be used to diagnose parathyroid cancer

When to seek urgent medical care?

Directions to Hospitals Treating Parathyroid Cancer

Treatment options

  • Treatment of parathyroid cancer includes:

Where to find medical care for parathyroid cancer?

Directions to Hospitals Treating Parathyroid Cancer

What to expect (Outlook/Prognosis)?

Possible complications

Sources