Linitis plastica causes: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (3 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Linitis plastica}} | {{Linitis plastica}} | ||
{{CMG}}{{AE}} {{ | {{CMG}};{{AE}}{{HM}} | ||
==Overview== | ==Overview== | ||
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in [[CDH1 (gene)|CDH1]] gene. [[CDH1 (gene)|CDH1]] gene codes for [[Cadherin|E-cadherin]] adhesion protein. Secondarily, linitis plastica may be caused by [[metastasis]] to the [[stomach]] or by the [[Lye|ingestion of lye]]. | |||
==Causes== | ==Causes== | ||
*The | ===Primary Causes=== | ||
* | *Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.<ref name="pmid14630673">{{cite journal |vauthors=Graziano F, Humar B, Guilford P |title=The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice |journal=Ann. Oncol. |volume=14 |issue=12 |pages=1705–13 |year=2003 |pmid=14630673 |doi= |url=}}</ref> | ||
* [[Somatic]] [[mutations]] in the ''CDH1'' [[gene]] can occur by: | |||
**Hypermethylation | |||
**[[Loss of heterozygosity]] | |||
**Silencing mutations | |||
===Secondary causes=== | |||
*[[Lye]] ingestion | |||
*[[Metastasis|Metastatic]] infiltration of the stomach by: | |||
**[[Lung cancer]] | |||
**[[Breast cancer]] | |||
**[[Non-Hodgkin lymphoma]]<ref name="pmid8888226">{{cite journal |vauthors=Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC |title=Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica |journal=Radiology |volume=201 |issue=2 |pages=375–8 |year=1996 |pmid=8888226 |doi=10.1148/radiology.201.2.8888226 |url=}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 17:07, 8 January 2018
|
Linitis plastica Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Linitis plastica causes On the Web |
|
American Roentgen Ray Society Images of Linitis plastica causes |
|
Risk calculators and risk factors for Linitis plastica causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by metastasis to the stomach or by the ingestion of lye.
Causes
Primary Causes
- Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.[1]
- Somatic mutations in the CDH1 gene can occur by:
- Hypermethylation
- Loss of heterozygosity
- Silencing mutations
Secondary causes
- Lye ingestion
- Metastatic infiltration of the stomach by:
References
- ↑ Graziano F, Humar B, Guilford P (2003). "The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice". Ann. Oncol. 14 (12): 1705–13. PMID 14630673.
- ↑ Levine MS, Pantongrag-Brown L, Aguilera NS, Buck JL, Buetow PC (1996). "Non-Hodgkin lymphoma of the stomach: a cause of linitis plastica". Radiology. 201 (2): 375–8. doi:10.1148/radiology.201.2.8888226. PMID 8888226.