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==Overview==
==Overview==
Primary infection is thought to be autolimited and almost [[asymptomatic]] as [[histoplasmosis]] or [[Coccidioidomycosis|Valley Fever]]. In young people, there is a progressive form of the disease with high [[fever]], generalized [[lymphadenopathy]] and pulmonary involvement with milliary lesions. This juvenile form has a more severe [[prognosis]] even with treatment. The most common form is the so called adult form of paracoccidioidomycosis (PCM) that is almost certainly a reactivation of the disease. [[Chronic (medical)|Chronic]] PCM has mainly pulmonary symptoms.<ref>Paracoccidioidomycosis. Wikipedia.https://en.wikipedia.org/wiki/Paracoccidioidomycosis. Accessed on January 12, 2015</ref>  
Primary infection is thought to be autolimited and almost asymptomatic as [[histoplasmosis]] or [[Coccidioidomycosis|Valley Fever]]. In young individuals, there is a progressive form of the disease with high [[fever]], generalized [[lymphadenopathy]] and pulmonary involvement with milliary lesions. The juvenile form has a more severe [[prognosis]] even with treatment. The most common form is the so called adult form of paracoccidioidomycosis (PCM) that is almost certainly a reactivation of the disease. Chronic PCM has mainly pulmonary symptoms.<ref>Paracoccidioidomycosis. Wikipedia.https://en.wikipedia.org/wiki/Paracoccidioidomycosis. Accessed on January 12, 2015</ref>  


==History==
==History==
Paracoccidioidomycosis has been reported as an autochthonous disease, that tends to affect agriculture workers from southern Mexico to northern Argentina. Paracoccidioidomycosis is prevalent in Brazil, Colombia, Venezuela, and Argentina, and is classically associated with individuals from rural areas. Travellers that have been to [[Endemic (epidemiology)|endemic]] areas are in risk of contracting PCM as well as the endemics areas population.<ref>Paracoccidioidomycosis. Wikipedia.https://en.wikipedia.org/wiki/Paracoccidioidomycosis. Accessed on January 12, 2015</ref>
Paracoccidioidomycosis has been reported as an autochthonous disease that tends to affect agriculture workers from southern Mexico to northern Argentina. Paracoccidioidomycosis is prevalent in Brazil, Colombia, Venezuela, and Argentina, and is classically associated with individuals from rural areas. Travellers that have been to endemic areas are in risk of contracting PCM as well as the endemics areas population.<ref>Paracoccidioidomycosis. Wikipedia.https://en.wikipedia.org/wiki/Paracoccidioidomycosis. Accessed on January 12, 2015</ref>


==Symptoms==
==Symptoms==
[[Acute (medical)|Acute]]:
 
=== Acute:<ref name="aaa">Pereira R, Bucaretchi F, Barison E, Hessel G, Tresoldi A. Paracoccidioidomycosis in children: Clinical presentation, follow-up and outcome. ''Rev. Inst. Med. trop. S. Paulo.''2004;46(3):127-131. </ref> ===
*[[Fever]]
*[[Fever]]
*[[Lymphadenopathy|Lymph swelling]]
*[[Lymphadenopathy|Lymph swelling]]
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*[[Asthenia]]
*[[Asthenia]]
*[[Weight loss]]
*[[Weight loss]]
*[[Osteoarticular pain]]
*Osteoarticular tumefaction
*Osteoarticular tumefaction
*[[Skin lesions]]<ref name="aaa">Pereira R, Bucaretchi F, Barison E, Hessel G, Tresoldi A. Paracoccidioidomycosis in children: Clinical presentation, follow-up and outcome. ''Rev. Inst. Med. trop. S. Paulo.''2004;46(3):127-131. </ref>


[[Chronic (medical)|Chronic]]:
=== Chronic:<ref name="g">Vignolles M, Melo V, Paniagua B, Giménez M,  Piccoli L. Paracoccidioidomicosis genital: localización infrecuente. ''Arch. Argent. Dermatol. ''2015;65(2):54-56</ref><ref name="pmid10742725">{{cite journal| author=Severo LC, Kauer CL, Oliveira Fd, Rigatti RA, Hartmann AA, Londero AT| title=Paracoccidioidomycosis of the male genital tract. Report of eleven cases and a review of Brazilian literature. | journal=Rev Inst Med Trop Sao Paulo | year= 2000 | volume= 42 | issue= 1 | pages= 38-40 | pmid=10742725 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10742725  }} </ref><ref name="o">Dawaher J, Colella MR, Rosello A, Perez C, Olaizola C, Newman W, Landaeta ME, Rangel L, Mata S. Paracoccidioidomicosis: clínica, epidemiología y tratamiento ''Kasmera''2012;40(2):142-185</ref><ref name="a">Vargas J, Vargas R. Paracoccidioidomicosis. ''Rev. enferm. infecc. trop. ''2009;1(1):49-56</ref> ===
*[[Dry cough]]
*[[Dry cough]]
*[[Dyspnea]]
*[[Dyspnea]]
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*[[Fever]]
*[[Fever]]
*[[Skin lesion|Skin lesions]]: mucose oropharynx ulcers
*[[Skin lesion|Skin lesions]]: mucose oropharynx ulcers
*Sialorrhea
*[[Drooling|Sialorrhea]]
*[[Odynophagia]]
*[[Odynophagia]]
*[[Skin lesions|Cutaneous lesions]]: Erythematous ulcers (lip, tongue, palate, cheek, nose, larynx, penis, eyes)<ref name="g">Vignolles M, Melo V, Paniagua B, Giménez M,  Piccoli L. Paracoccidioidomicosis genital: localización infrecuente. ''Arch. Argent. Dermatol. ''2015;65(2):54-56</ref><ref name="pmid10742725">{{cite journal| author=Severo LC, Kauer CL, Oliveira Fd, Rigatti RA, Hartmann AA, Londero AT| title=Paracoccidioidomycosis of the male genital tract. Report of eleven cases and a review of Brazilian literature. | journal=Rev Inst Med Trop Sao Paulo | year= 2000 | volume= 42 | issue= 1 | pages= 38-40 | pmid=10742725 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10742725  }} </ref><ref name="o">Dawaher J, Colella MR, Rosello A, Perez C, Olaizola C, Newman W, Landaeta ME, Rangel L, Mata S. Paracoccidioidomicosis: clínica, epidemiología y tratamiento ''Kasmera''2012;40(2):142-185</ref><ref name="a">Vargas J, Vargas R. Paracoccidioidomicosis. ''Rev. enferm. infecc. trop. ''2009;1(1):49-56</ref>
*[[Skin lesions|Cutaneous lesions]]: Erythematous ulcers (lip, tongue, palate, cheek, nose, larynx, penis, eyes)
<gallery>
<gallery>
Image:Paracoccidioidomycosis-cara.jpg|This image from 1965 depicted a right anterior-oblique view of a Sao Paulo, Brazilian man’s face that displayed the severely-destructive cutaneous pathologic changes seen there, due of the mycotic infection, paracoccidioidomycosis. Symptoms involve ulcerations of the skin and mucous membranes of the mouth, nose and pharynx.<ref>Paracoccidioidomycosis. CDC Public Health Image Library (PHIL).http://phil.cdc.gov/phil/details.asp. Accessed on January 20, 2016</ref>
Image:Paracoccidioidomycosis-cara.jpg|This image from 1965 depicted a right anterior-oblique view of a Sao Paulo, Brazilian man’s face that displayed the severely-destructive cutaneous pathologic changes seen there, due of the mycotic infection, paracoccidioidomycosis. Symptoms involve ulcerations of the skin and mucous membranes of the mouth, nose and pharynx.<ref>Paracoccidioidomycosis. CDC Public Health Image Library (PHIL).http://phil.cdc.gov/phil/details.asp. Accessed on January 20, 2016</ref>

Latest revision as of 21:45, 12 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Danitza Lukac

Overview

Primary infection is thought to be autolimited and almost asymptomatic as histoplasmosis or Valley Fever. In young individuals, there is a progressive form of the disease with high fever, generalized lymphadenopathy and pulmonary involvement with milliary lesions. The juvenile form has a more severe prognosis even with treatment. The most common form is the so called adult form of paracoccidioidomycosis (PCM) that is almost certainly a reactivation of the disease. Chronic PCM has mainly pulmonary symptoms.[1]

History

Paracoccidioidomycosis has been reported as an autochthonous disease that tends to affect agriculture workers from southern Mexico to northern Argentina. Paracoccidioidomycosis is prevalent in Brazil, Colombia, Venezuela, and Argentina, and is classically associated with individuals from rural areas. Travellers that have been to endemic areas are in risk of contracting PCM as well as the endemics areas population.[2]

Symptoms

Acute:[3]

Chronic:[4][5][6][7]

  • This image from 1965 depicted a right anterior-oblique view of a Sao Paulo, Brazilian man’s face that displayed the severely-destructive cutaneous pathologic changes seen there, due of the mycotic infection, paracoccidioidomycosis. Symptoms involve ulcerations of the skin and mucous membranes of the mouth, nose and pharynx.[8]

    This image from 1965 depicted a right anterior-oblique view of a Sao Paulo, Brazilian man’s face that displayed the severely-destructive cutaneous pathologic changes seen there, due of the mycotic infection, paracoccidioidomycosis. Symptoms involve ulcerations of the skin and mucous membranes of the mouth, nose and pharynx.[8]

  • Captured prior to beginning any treatment, this image depicts an anterior view of a male patient’s open mouth, revealing the man’s tongue, which exhibited a lesion on its left lateral edge that proved to be a case of paracoccidioidomycosis.[9]

    Captured prior to beginning any treatment, this image depicts an anterior view of a male patient’s open mouth, revealing the man’s tongue, which exhibited a lesion on its left lateral edge that proved to be a case of paracoccidioidomycosis.[9]

  • This image from 1965 depicted an anterior view of a Sao Paulo, Brazilian child’s face that displayed the ravages of the mycotic infection, paracoccidioidomycosis.[10]

    This image from 1965 depicted an anterior view of a Sao Paulo, Brazilian child’s face that displayed the ravages of the mycotic infection, paracoccidioidomycosis.[10]

References

  1. ↑ Paracoccidioidomycosis. Wikipedia.https://en.wikipedia.org/wiki/Paracoccidioidomycosis. Accessed on January 12, 2015
  2. ↑ Paracoccidioidomycosis. Wikipedia.https://en.wikipedia.org/wiki/Paracoccidioidomycosis. Accessed on January 12, 2015
  3. ↑ Pereira R, Bucaretchi F, Barison E, Hessel G, Tresoldi A. Paracoccidioidomycosis in children: Clinical presentation, follow-up and outcome. Rev. Inst. Med. trop. S. Paulo.2004;46(3):127-131.
  4. ↑ Vignolles M, Melo V, Paniagua B, Giménez M, Piccoli L. Paracoccidioidomicosis genital: localización infrecuente. Arch. Argent. Dermatol. 2015;65(2):54-56
  5. ↑ Severo LC, Kauer CL, Oliveira Fd, Rigatti RA, Hartmann AA, Londero AT (2000). "Paracoccidioidomycosis of the male genital tract. Report of eleven cases and a review of Brazilian literature". Rev Inst Med Trop Sao Paulo. 42 (1): 38–40. PMID 10742725.
  6. ↑ Dawaher J, Colella MR, Rosello A, Perez C, Olaizola C, Newman W, Landaeta ME, Rangel L, Mata S. Paracoccidioidomicosis: clínica, epidemiología y tratamiento Kasmera2012;40(2):142-185
  7. ↑ Vargas J, Vargas R. Paracoccidioidomicosis. Rev. enferm. infecc. trop. 2009;1(1):49-56
  8. ↑ Paracoccidioidomycosis. CDC Public Health Image Library (PHIL).http://phil.cdc.gov/phil/details.asp. Accessed on January 20, 2016
  9. ↑ Paracoccidioidomycosis. CDC Public Health Image Library (PHIL).http://phil.cdc.gov/phil/details.asp. Accessed on January 20, 2016
  10. ↑ Paracoccidioidomycosis. CDC Public Health Image Library (PHIL).http://phil.cdc.gov/phil/details.asp. Accessed on January 20, 2016
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