Osteochondroma overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Osteochondroma '''(also known as '''osteocartilaginous exostosis''') is a [[benign]] [[bone]] [[tumor]] that consists of [[cartilage]] and [[bone]]. Osteochondromas arise from cartilage, which is normally involved in the mechanical support of the bone. These tumors take the form of cartilage-capped bony projections or outgrowth on the surface of bones, also known as ''exostoses''.<ref name="Panagiotis2008">{{cite journal|last=Panagiotis|first=Kitsoulis|author2=Vassiliki Galani |author3=Kalliopi Stefanaki |author4=Georgios Paraskevas |author5=Georgios Karatzias |author6=Niki John Agnantis |author7=Maria Bai |title=Osteochondromas: Review of the Clinical, Radiological and Pathological Features|journal=In Vivo|date=October 2008|volume=22|issue=5|pages=633–646|url=http://iv.iiarjournals.org/content/22/5/633.short|accessdate=22 March 2014}}</ref> Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones. Development of osteochondromas is the result of the developmental anomaly of skeletal growth. | '''Osteochondroma '''(also known as '''''"osteocartilaginous exostosis"''''') is a [[benign]] [[bone]] [[tumor]] that consists of [[cartilage]] and [[bone]]. Osteochondromas arise from cartilage, which is normally involved in the mechanical support of the bone. These tumors take the form of cartilage-capped bony projections or outgrowth on the surface of bones, also known as ''[[exostoses]]''.<ref name="Panagiotis2008">{{cite journal|last=Panagiotis|first=Kitsoulis|author2=Vassiliki Galani |author3=Kalliopi Stefanaki |author4=Georgios Paraskevas |author5=Georgios Karatzias |author6=Niki John Agnantis |author7=Maria Bai |title=Osteochondromas: Review of the Clinical, Radiological and Pathological Features|journal=In Vivo|date=October 2008|volume=22|issue=5|pages=633–646|url=http://iv.iiarjournals.org/content/22/5/633.short|accessdate=22 March 2014}}</ref> Osteochondroma is the most common benign bone tumor and usually occurs in the [[metaphyseal]] region of the long bones. Osteochondromas may be classified into 2 subtypes: solitary osteochondromas (non-hereditary) and multiple osteochondromas ([[hereditary]]); the majority of these tumors present as solitary lesions (85%).<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> Development of osteochondromas is the result of the developmental anomaly of skeletal growth. [[Genes]] involved in the [[pathogenesis]] of osteochondroma include [[EXT1]] and EXT2 genes. Osteochondroma is associated with a number of syndromes that include [[Langer-Giedion syndrome]], Potocki-Shaffer syndrome, and metachondromatosis syndrome. Osteochondromas are usually found in adolescents and children. Males are more commonly affected with osteochondroma than females. The incidence of osteochondroma is approximately 0.9 per 100,000 individuals. If left untreated, progression occurs slow and is then followed by malignant transformation. The treatment choice for osteochondroma is surgical removal of solitary lesion or partial excision of the outgrowth. | ||
==Historical Perspective== | ==Historical Perspective== | ||
Osteochondroma was first described by Henry L. Jaffe in 1952.<ref> Tumors and Tumorous Conditions of the Bones and Joints by Henry L. Jaffe, Philadelphia, Lea and Febiger 1958</ref> | Osteochondroma was first described by Henry L. Jaffe, an American [[pathologist]], in 1952.<ref> Tumors and Tumorous Conditions of the Bones and Joints by Henry L. Jaffe, Philadelphia, Lea and Febiger 1958</ref> | ||
==Classification== | ==Classification== | ||
Osteochondromas may be classified into 2 subtypes: solitary osteochondromas (non-hereditary) and multiple osteochondromas (hereditary).<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> | |||
==Pathophysiology== | ==Pathophysiology== | ||
Osteochondroma arises from the cartilage cells, which are normally involved in the mechanical support of the bone. | Osteochondroma arises from the cartilage [[cells]] ([[chondrocytes]]), which are normally involved in the mechanical support of the [[bone]]. The pathogenesis of osteochondroma consists of abnormal outgrowth of [[bone]] and cartilage, associated with the aberrant development of the growth plate.<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> [[Genes]] involved in the [[pathogenesis]] of osteochondroma include [[EXT1]] and EXT2 genes. Osteochondroma is associated with a number of syndromes that include [[Langer-Giedion syndrome]], Potocki-Shaffer syndrome, and metachondromatosis syndrome. On gross pathology, osteochondromas have a "mushroom-like shape", the tumor size ranges from 1 to 2 cm, and they are normally located on the metaphysial region of the affected bone.<ref name="libre">Osteochondroma. Libre Pathology. http://librepathology.org/wiki/index.php/Osteochondroma Accessed on January 27, 2015</ref> On microscopic histopathological analysis, osteochondroma shows cartilage cells growing in columns with a lobular arrangement.<ref name="pmid10398153">{{cite journal |vauthors=Porter DE, Simpson AH |title=The neoplastic pathogenesis of solitary and multiple osteochondromas |journal=The Journal of Pathology |volume=188 |issue=2 |pages=119–25 |year=1999 |pmid=10398153 |doi=10.1002/(SICI)1096-9896(199906)188:2<119::AID-PATH321>3.0.CO;2-N |url=http://dx.doi.org/10.1002/(SICI)1096-9896(199906)188:2<119::AID-PATH321>3.0.CO;2-N}}</ref> | ||
==Causes== | ==Causes== | ||
There are no established direct causes for osteochondroma. The development of hereditary multiple osteochondroma may be the result of multiple genetic mutations. | There are no established direct causes for osteochondroma. The development of hereditary multiple osteochondroma may be the result of multiple genetic [[mutations]].<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> | ||
==Differentiating Osteoid Osteoma from other Diseases== | ==Differentiating Osteoid Osteoma from other Diseases== | ||
Osteochondroma must be differentiated from other diseases that cause | Osteochondroma must be differentiated from other diseases that cause bone deformity, bone growth, overlying [[bursitis]], and mechanical joint problems such as [[enchondroma]], [[chondroblastoma]], [[periosteal chondroma]], and chondromyxoid fibroma.<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Osteochondroma is the most common benign bone tumor among general population. The incidence of osteochondroma is approximately 0.9 per 100,000 individuals in the general population. The incidence of osteochondroma decreases with age; the median age at diagnosis is between 10 to 13 years. Males | Osteochondroma is the most common benign bone tumor among general population.<ref name="pmid10992031">{{cite journal |vauthors=Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH |title=Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation |journal=Radiographics : a Review Publication of the Radiological Society of North America, Inc |volume=20 |issue=5 |pages=1407–34 |year=2000 |pmid=10992031 |doi=10.1148/radiographics.20.5.g00se171407 |url=http://pubs.rsna.org/doi/10.1148/radiographics.20.5.g00se171407?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed}}</ref> The incidence of osteochondroma is approximately 0.9 per 100,000 individuals in the general population. The incidence of osteochondroma decreases with age; the median age at diagnosis is between 10 to 13 years. Males are more commonly affected with osteochondroma than females. Osteochondroma usually affects individuals of the Caucasian race.<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors in the development of osteochondromas, include: previous [[trauma]] to the growth plate, exposure to previous [[radiation]], and [[congenital]] limb anomalies.<ref name="pmid10992031">{{cite journal |vauthors=Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH |title=Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation |journal=Radiographics : a Review Publication of the Radiological Society of North America, Inc |volume=20 |issue=5 |pages=1407–34 |year=2000 |pmid=10992031 |doi=10.1148/radiographics.20.5.g00se171407 |url=http://pubs.rsna.org/doi/10.1148/radiographics.20.5.g00se171407?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed}}</ref> | |||
==Screening== | ==Screening== | ||
According to the the Canadian Society of Cancer, there is insufficient evidence to recommend routine screening for osteochondroma.<ref>Osteochondroma. Candian Society of Cancer. http://www.cancer.ca/en/cancer-information/cancer-type/bone/bone-cancer/benign-tumours/?region=bc Accessed on January 27, 2016</ref> | |||
==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
If left untreated, patients with osteochondroma may progress to develop overlying [[bursitis]], vascular compromise, and rise to malignant chondrosarcoma. Common complications of osteochondroma include [[fracture]], osseous deformation, and [[growth]] arrest. Prognosis is generally regarded as good after surgical excision. The [[recurrence]] rate of osteochondroma is 2%.<ref name="pmid10992031">{{cite journal |vauthors=Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH |title=Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation |journal=Radiographics : a Review Publication of the Radiological Society of North America, Inc |volume=20 |issue=5 |pages=1407–34 |year=2000 |pmid=10992031 |doi=10.1148/radiographics.20.5.g00se171407 |url=http://pubs.rsna.org/doi/10.1148/radiographics.20.5.g00se171407?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed}}</ref> | |||
==Diagnosis== | ==Diagnosis== | ||
===Staging=== | ===Staging=== | ||
According to the Musculoskeletal Tumor Society (MSTS) classification, there are 3 stages of osteochondroma based on the tumoral activity. Each stage is assigned a number that designate the level of bone erosion. The different stages of osteochondroma, include: stage I, stage II, and stage III.<ref name="pmid20333492">{{cite journal |vauthors=Jawad MU, Scully SP |title=In brief: classifications in brief: enneking classification: benign and malignant tumors of the musculoskeletal system |journal=Clinical Orthopaedics and Related Research |volume=468 |issue=7 |pages=2000–2 |year=2010 |pmid=20333492 |pmc=2882012 |doi=10.1007/s11999-010-1315-7 |url=http://dx.doi.org/10.1007/s11999-010-1315-7}}</ref> | |||
===History and Symptoms=== | ===History and Symptoms=== | ||
The hallmark of osteochondroma is a painless growing [[mass]]. A positive history of [[Langer-Giedion syndrome]], Potocki-Shaffer syndrome, or metachondromatosis syndrome is highly suggestive of multiple osteochondromas. Symptoms related with osteochondroma will vary depending on the size and location of the tumor. Common symptoms of osteochondroma may include limb [[numbness]], adjacent muscle [[soreness]], and [[claudication]].<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> | |||
===Physical Examination=== | ===Physical Examination=== | ||
Physical examination findings of osteochondroma will depend on the location of the tumor. Physical examination of patients with osteochondroma is usually remarkable for bone deformity, limited range of limb [[motion]], [[loss of pulse]], and color change.<ref name="pmid18853760">{{cite journal |vauthors=Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M |title=Osteochondromas: review of the clinical, radiological and pathological features |journal=In Vivo (Athens, Greece) |volume=22 |issue=5 |pages=633–46 |year=2008 |pmid=18853760 |doi= |url=http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=18853760}}</ref> | |||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
There are no diagnostic laboratory findings associated with osteochondroma. | |||
===X Ray=== | ===X Ray=== | ||
On conventional radiography, characteristic findings of osteochondroma include: sessile or pedunculated bony growth, located at the metaphyseal region, bone growth projecting away from the epiphysis, and widening of the metaphysis.<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref> | |||
===CT=== | ===CT=== | ||
On CT scan, osteochondroma shows the same findings as on radiograph, but it has better accuracy to demonstrate medullary continuity and the cartilage cap.<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref> | |||
===MRI=== | ===MRI=== | ||
On MRI, osteochondroma shows cartilage thickness (and thus assessing for malignant transformation), presence of edema in bone or adjacent soft tissues, and visualization of neurovascular structures. MRI is the imaging modality of choice to assess malignant transformation of osteochondroma.<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref> | |||
===Ultrasound=== | ===Ultrasound=== | ||
On ultrasound, the osteochondroma cartilage cap is visualized accurately as a hypoechoic region bounded by bone.<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref> | |||
===Other Imaging Findings=== | ===Other Imaging Findings=== | ||
Other imaging findings, include nuclear medicine (bone [[scintigraphy]]) in which osteochondroma shows increased uptake on bone scans. Conversely, presence of increased activity in adults should raise the possibility of a complication (e.g. [[fracture]], [[malignancy]]).<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref> | |||
===Other Diagnostic Studies=== | ===Other Diagnostic Studies=== | ||
There are no other diagnostic studies for osteochondroma.<ref name= "radio"> Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016</ref> | |||
==Treatment== | ==Treatment== | ||
===Medical Therapy=== | ===Medical Therapy=== | ||
There is no medical treatment for osteochondroma; Observation surveillance is suggested if lesions are asymptomatic. | |||
===Surgery=== | ===Surgery=== | ||
Surgery is the mainstay of therapy for osteochondroma. | Surgery is the mainstay of therapy for osteochondroma. Surgery for osteochondroma should be considered, until bone growth is complete (assessed by mature skeleton x-ray evaluation).<ref name="wikibook">Diagnostic Radiology: Musculoskeletal Imaging: Osteochondroma. WikiBooks.(2015)https://en.wikibooks.org/wiki/Diagnostic_Radiology/Musculoskeletal_Imaging/Tumors_Basic/Osteochondroma Accessed on January 28, 2016</ref> | ||
==Primary Prevention== | ==Primary Prevention== | ||
There is no primary prevention for osteochondroma. | |||
==Secondary Prevention== | ==Secondary Prevention== | ||
There is no secondary prevention for osteochondroma. | |||
==References== | ==References== | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Orthopedics]] | |||
Latest revision as of 14:50, 27 November 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
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Overview
Osteochondroma (also known as "osteocartilaginous exostosis") is a benign bone tumor that consists of cartilage and bone. Osteochondromas arise from cartilage, which is normally involved in the mechanical support of the bone. These tumors take the form of cartilage-capped bony projections or outgrowth on the surface of bones, also known as exostoses.[1] Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones. Osteochondromas may be classified into 2 subtypes: solitary osteochondromas (non-hereditary) and multiple osteochondromas (hereditary); the majority of these tumors present as solitary lesions (85%).[2] Development of osteochondromas is the result of the developmental anomaly of skeletal growth. Genes involved in the pathogenesis of osteochondroma include EXT1 and EXT2 genes. Osteochondroma is associated with a number of syndromes that include Langer-Giedion syndrome, Potocki-Shaffer syndrome, and metachondromatosis syndrome. Osteochondromas are usually found in adolescents and children. Males are more commonly affected with osteochondroma than females. The incidence of osteochondroma is approximately 0.9 per 100,000 individuals. If left untreated, progression occurs slow and is then followed by malignant transformation. The treatment choice for osteochondroma is surgical removal of solitary lesion or partial excision of the outgrowth.
Historical Perspective
Osteochondroma was first described by Henry L. Jaffe, an American pathologist, in 1952.[3]
Classification
Osteochondromas may be classified into 2 subtypes: solitary osteochondromas (non-hereditary) and multiple osteochondromas (hereditary).[2]
Pathophysiology
Osteochondroma arises from the cartilage cells (chondrocytes), which are normally involved in the mechanical support of the bone. The pathogenesis of osteochondroma consists of abnormal outgrowth of bone and cartilage, associated with the aberrant development of the growth plate.[2] Genes involved in the pathogenesis of osteochondroma include EXT1 and EXT2 genes. Osteochondroma is associated with a number of syndromes that include Langer-Giedion syndrome, Potocki-Shaffer syndrome, and metachondromatosis syndrome. On gross pathology, osteochondromas have a "mushroom-like shape", the tumor size ranges from 1 to 2 cm, and they are normally located on the metaphysial region of the affected bone.[4] On microscopic histopathological analysis, osteochondroma shows cartilage cells growing in columns with a lobular arrangement.[5]
Causes
There are no established direct causes for osteochondroma. The development of hereditary multiple osteochondroma may be the result of multiple genetic mutations.[2]
Differentiating Osteoid Osteoma from other Diseases
Osteochondroma must be differentiated from other diseases that cause bone deformity, bone growth, overlying bursitis, and mechanical joint problems such as enchondroma, chondroblastoma, periosteal chondroma, and chondromyxoid fibroma.[2]
Epidemiology and Demographics
Osteochondroma is the most common benign bone tumor among general population.[6] The incidence of osteochondroma is approximately 0.9 per 100,000 individuals in the general population. The incidence of osteochondroma decreases with age; the median age at diagnosis is between 10 to 13 years. Males are more commonly affected with osteochondroma than females. Osteochondroma usually affects individuals of the Caucasian race.[2]
Risk Factors
Common risk factors in the development of osteochondromas, include: previous trauma to the growth plate, exposure to previous radiation, and congenital limb anomalies.[6]
Screening
According to the the Canadian Society of Cancer, there is insufficient evidence to recommend routine screening for osteochondroma.[7]
Natural History, Complications and Prognosis
If left untreated, patients with osteochondroma may progress to develop overlying bursitis, vascular compromise, and rise to malignant chondrosarcoma. Common complications of osteochondroma include fracture, osseous deformation, and growth arrest. Prognosis is generally regarded as good after surgical excision. The recurrence rate of osteochondroma is 2%.[6]
Diagnosis
Staging
According to the Musculoskeletal Tumor Society (MSTS) classification, there are 3 stages of osteochondroma based on the tumoral activity. Each stage is assigned a number that designate the level of bone erosion. The different stages of osteochondroma, include: stage I, stage II, and stage III.[8]
History and Symptoms
The hallmark of osteochondroma is a painless growing mass. A positive history of Langer-Giedion syndrome, Potocki-Shaffer syndrome, or metachondromatosis syndrome is highly suggestive of multiple osteochondromas. Symptoms related with osteochondroma will vary depending on the size and location of the tumor. Common symptoms of osteochondroma may include limb numbness, adjacent muscle soreness, and claudication.[2]
Physical Examination
Physical examination findings of osteochondroma will depend on the location of the tumor. Physical examination of patients with osteochondroma is usually remarkable for bone deformity, limited range of limb motion, loss of pulse, and color change.[2]
Laboratory Findings
There are no diagnostic laboratory findings associated with osteochondroma.
X Ray
On conventional radiography, characteristic findings of osteochondroma include: sessile or pedunculated bony growth, located at the metaphyseal region, bone growth projecting away from the epiphysis, and widening of the metaphysis.[9]
CT
On CT scan, osteochondroma shows the same findings as on radiograph, but it has better accuracy to demonstrate medullary continuity and the cartilage cap.[9]
MRI
On MRI, osteochondroma shows cartilage thickness (and thus assessing for malignant transformation), presence of edema in bone or adjacent soft tissues, and visualization of neurovascular structures. MRI is the imaging modality of choice to assess malignant transformation of osteochondroma.[9]
Ultrasound
On ultrasound, the osteochondroma cartilage cap is visualized accurately as a hypoechoic region bounded by bone.[9]
Other Imaging Findings
Other imaging findings, include nuclear medicine (bone scintigraphy) in which osteochondroma shows increased uptake on bone scans. Conversely, presence of increased activity in adults should raise the possibility of a complication (e.g. fracture, malignancy).[9]
Other Diagnostic Studies
There are no other diagnostic studies for osteochondroma.[9]
Treatment
Medical Therapy
There is no medical treatment for osteochondroma; Observation surveillance is suggested if lesions are asymptomatic.
Surgery
Surgery is the mainstay of therapy for osteochondroma. Surgery for osteochondroma should be considered, until bone growth is complete (assessed by mature skeleton x-ray evaluation).[10]
Primary Prevention
There is no primary prevention for osteochondroma.
Secondary Prevention
There is no secondary prevention for osteochondroma.
References
- ↑ Panagiotis, Kitsoulis; Vassiliki Galani; Kalliopi Stefanaki; Georgios Paraskevas; Georgios Karatzias; Niki John Agnantis; Maria Bai (October 2008). "Osteochondromas: Review of the Clinical, Radiological and Pathological Features". In Vivo. 22 (5): 633–646. Retrieved 22 March 2014.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Kitsoulis P, Galani V, Stefanaki K, Paraskevas G, Karatzias G, Agnantis NJ, Bai M (2008). "Osteochondromas: review of the clinical, radiological and pathological features". In Vivo (Athens, Greece). 22 (5): 633–46. PMID 18853760.
- ↑ Tumors and Tumorous Conditions of the Bones and Joints by Henry L. Jaffe, Philadelphia, Lea and Febiger 1958
- ↑ Osteochondroma. Libre Pathology. http://librepathology.org/wiki/index.php/Osteochondroma Accessed on January 27, 2015
- ↑ Porter DE, Simpson AH (1999). <119::AID-PATH321>3.0.CO;2-N "The neoplastic pathogenesis of solitary and multiple osteochondromas". The Journal of Pathology. 188 (2): 119–25. doi:10.1002/(SICI)1096-9896(199906)188:2<119::AID-PATH321>3.0.CO;2-N. PMID 10398153.
- ↑ 6.0 6.1 6.2 Murphey MD, Choi JJ, Kransdorf MJ, Flemming DJ, Gannon FH (2000). "Imaging of osteochondroma: variants and complications with radiologic-pathologic correlation". Radiographics : a Review Publication of the Radiological Society of North America, Inc. 20 (5): 1407–34. doi:10.1148/radiographics.20.5.g00se171407. PMID 10992031.
- ↑ Osteochondroma. Candian Society of Cancer. http://www.cancer.ca/en/cancer-information/cancer-type/bone/bone-cancer/benign-tumours/?region=bc Accessed on January 27, 2016
- ↑ Jawad MU, Scully SP (2010). "In brief: classifications in brief: enneking classification: benign and malignant tumors of the musculoskeletal system". Clinical Orthopaedics and Related Research. 468 (7): 2000–2. doi:10.1007/s11999-010-1315-7. PMC 2882012. PMID 20333492.
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Osteochondroma. Dr Yuranga Weerakkody. Radiopedia. http://radiopaedia.org/articles/osteochondroma Accessed on January 28, 2016
- ↑ Diagnostic Radiology: Musculoskeletal Imaging: Osteochondroma. WikiBooks.(2015)https://en.wikibooks.org/wiki/Diagnostic_Radiology/Musculoskeletal_Imaging/Tumors_Basic/Osteochondroma Accessed on January 28, 2016