Extramammary Paget's disease classification: Difference between revisions
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==Overview== | ==Overview== | ||
Extramammary Paget's disease may be classified into two groups based on the origin of the Paget's cells. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected. | Extramammary Paget's disease may be classified into two groups based on the origin of the Paget's cells. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected. | ||
==Classification== | ==Classification== | ||
===Classification Based on Affected Area=== | ===Classification Based on Affected Area=== | ||
The classification of extramammary Paget's disease based on the site and area affeced is shown below in a tabular form: | The classification of extramammary Paget's disease based on the site and area affeced is shown below in a tabular form: | ||
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! style="background: #4479BA; width: 20%;" | {{fontcolor|#FFF|Type of Extramammary Paget's Disease}} | ! style="background: #4479BA; width: 20%;" | {{fontcolor|#FFF|Type of Extramammary Paget's Disease}} | ||
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===Classification Based on Origin of Paget's Cells=== | ===Classification Based on Origin of Paget's Cells=== | ||
Extramammary Paget's disease may be classified based on the origin of the Paget's cells according to | * Extramammary Paget's disease may be classified based on the origin of the Paget's cells according to a [[Classification|classification system]] proposed by Wilkinson and Brown into two groups: primary ([[cutaneous]]) and secondary (non-[[cutaneous]]). | ||
Classification of extramammary Paget's disease into two groups is shown below in a tabular form:<ref name="pmid12094382">{{cite journal| author=Wilkinson EJ, Brown HM| title=Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. | journal=Hum Pathol | year= 2002 | volume= 33 | issue= 5 | pages= 549-54 | pmid=12094382 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12094382 }} </ref> | |||
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center | * Classification of extramammary Paget's disease into two groups is shown below in a tabular form:<ref name="pmid12094382">{{cite journal| author=Wilkinson EJ, Brown HM| title=Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease. | journal=Hum Pathol | year= 2002 | volume= 33 | issue= 5 | pages= 549-54 | pmid=12094382 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12094382 }} </ref> | ||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF| Type of extramammary Paget's disease}} | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF| Type of extramammary Paget's disease}} | ||
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*Negative markers: Uroplakin (UPK); Cytokeratin (CK20) | *Negative markers: Uroplakin (UPK); Cytokeratin (CK20) | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold | | rowspan="3" style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | Secondary (non-cutaneous origin) | ||
| style="padding: 5px 5px; background: #F5F5F5;" | Anorectal origin | | style="padding: 5px 5px; background: #F5F5F5;" | Anorectal origin | ||
|style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Positive markers: Cytokeratin (CK20); Carcinoembryonic antigen (CEA) | *Positive markers: Cytokeratin (CK20); Carcinoembryonic antigen (CEA) | ||
*Negative markers: Cytokeratin (CK7); Gross cystic disease fluid protein (GCDFP): Uroplakin(UPK) | *Negative markers: Cytokeratin (CK7); Gross cystic disease fluid protein (GCDFP): Uroplakin(UPK) | ||
|- | |- | ||
|style="padding: 5px 5px; background: #F5F5F5;" | Urothelial origin | | style="padding: 5px 5px; background: #F5F5F5;" | Urothelial origin | ||
| style="padding: 5px 5px; background: #F5F5F5;" | | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
*Positive markers: Cytokeratin (CK7); Cytokeratin (CK20); Uroplakin (UPK) | *Positive markers: Cytokeratin (CK7); Cytokeratin (CK20); Uroplakin (UPK) | ||
*Negative markers: Gross cystic disease fluid protein (GCDFP15); [[Carcinoembryonic antigen]] (CEA) | *Negative markers: Gross cystic disease fluid protein (GCDFP15); [[Carcinoembryonic antigen]] (CEA) | ||
|- | |- | ||
|style="padding: 5px 5px; background: #F5F5F5;" | Other origin | | style="padding: 5px 5px; background: #F5F5F5;" | Other origin | ||
|style="padding: 5px 5px; background: #F5F5F5;" | Other origin antigen expression depends on primary tumor | | style="padding: 5px 5px; background: #F5F5F5;" | Other origin antigen expression depends on primary tumor | ||
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Latest revision as of 14:04, 9 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Extramammary Paget's disease may be classified into two groups based on the origin of the Paget's cells. Extramammary Paget's disease may be classified into four subtypes based on site of origin and area affected.
Classification
Classification Based on Affected Area
The classification of extramammary Paget's disease based on the site and area affeced is shown below in a tabular form:
| Type of Extramammary Paget's Disease | Description |
|---|---|
|
|
|
|
|
|
|
Classification Based on Origin of Paget's Cells
- Extramammary Paget's disease may be classified based on the origin of the Paget's cells according to a classification system proposed by Wilkinson and Brown into two groups: primary (cutaneous) and secondary (non-cutaneous).
- Classification of extramammary Paget's disease into two groups is shown below in a tabular form:[13]
| Type of extramammary Paget's disease | Features | Useful marker |
|---|---|---|
| Primary (cutaneous origin) |
|
|
| Secondary (non-cutaneous origin) | Anorectal origin |
|
| Urothelial origin |
| |
| Other origin | Other origin antigen expression depends on primary tumor |
References
- ↑ Curtin JP, Rubin SC, Jones WB, Hoskins WJ, Lewis JL (1990). "Paget's disease of the vulva". Gynecol Oncol. 39 (3): 374–7. PMID 2175288.
- ↑ Goldblum JR, Hart WR (1997). "Vulvar Paget's disease: a clinicopathologic and immunohistochemical study of 19 cases". Am J Surg Pathol. 21 (10): 1178–87. PMID 9331290.
- ↑ Fanning J, Lambert HC, Hale TM, Morris PC, Schuerch C (1999). "Paget's disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget's disease, and recurrence after surgical excision". Am J Obstet Gynecol. 180 (1 Pt 1): 24–7. PMID 9914572.
- ↑ van der Putte SC (1991). "Anogenital "sweat" glands. Histology and pathology of a gland that may mimic mammary glands". Am J Dermatopathol. 13 (6): 557–67. PMID 1666822.
- ↑ van der Putte SC, van Gorp LH (1994). "Adenocarcinoma of the mammary-like glands of the vulva: a concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget's disease". J Cutan Pathol. 21 (2): 157–63. PMID 8040464.
- ↑ 6.0 6.1 Powell FC, Bjornsson J, Doyle JA, Cooper AJ (1985). "Genital Paget's disease and urinary tract malignancy". J Am Acad Dermatol. 13 (1): 84–90. PMID 2993379.
- ↑ 7.0 7.1 Koga F, Gotoh S, Suzuki S (1997). "[A case of invasive bladder cancer with Pagetoid skin lesion of the vulva and anogenital Paget's disease]". Nihon Hinyokika Gakkai Zasshi. 88 (4): 503–6. PMID 9155118.
- ↑ Hayashibara Y, Ikeda S (1988). "[Extramammary Paget's disease with internal malignancies]". Gan To Kagaku Ryoho. 15 (4 Pt 2-3): 1569–75. PMID 2837997.
- ↑ Nakano S, Narita R, Tabaru A, Ogami Y, Otsuki M (1995). "Bile duct cancer associated with extramammary Paget's disease". Am J Gastroenterol. 90 (3): 507–8. PMID 7872301.
- ↑ Popiolek DA, Hajdu SI, Gal D (1998). "Synchronous Paget's disease of the vulva and breast". Gynecol Oncol. 71 (1): 137–40. doi:10.1006/gyno.1998.5136. PMID 9784335.
- ↑ Goldblum JR, Hart WR (1998). "Perianal Paget's disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma". Am J Surg Pathol. 22 (2): 170–9. PMID 9500217.
- ↑ Allan SJ, McLaren K, Aldridge RD (1998). "Paget's disease of the scrotum: a case exhibiting positive prostate-specific antigen staining and associated prostatic adenocarcinoma". Br J Dermatol. 138 (4): 689–91. PMID 9640381.
- ↑ Wilkinson EJ, Brown HM (2002). "Vulvar Paget disease of urothelial origin: a report of three cases and a proposed classification of vulvar Paget disease". Hum Pathol. 33 (5): 549–54. PMID 12094382.