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{{Epithelioid sarcome}}
{{Epithelioid sarcoma}}
{{CMG}}; {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Ammu}}
==Overview==
==Overview==
Other diagnostic studies for epithelioid sarcoma include genetic testing and immunohistochemistry.
==Genetic Testing==
==Genetic Testing==
*Loss of  INI1 (also known as hSNF5 and SMARCB1),which is a member of SWI/SNF multi-subunit chromatin remodeling complex located on the long arm of chromosome 22 (22q11.2), has been used as a diagnostic modality of epithelioid sarcoma.
==Immunohistochemistry==
*  Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma.
* Vimentin reactivity
* Pankeratin AE1/AE3 and epithelial membrane antigen<ref> Epithelioid sarcoma. Sarcomahelp (2016). http://sarcomahelp.org/epithelioid-sarcoma.html  Accessed on February 8, 2016</ref>
* Negative  S100
==Reference==
==Reference==
{{Reflit|2}}
{{Reflist|2}}
 
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Latest revision as of 22:20, 26 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Other diagnostic studies for epithelioid sarcoma include genetic testing and immunohistochemistry.

Genetic Testing

  • Loss of INI1 (also known as hSNF5 and SMARCB1),which is a member of SWI/SNF multi-subunit chromatin remodeling complex located on the long arm of chromosome 22 (22q11.2), has been used as a diagnostic modality of epithelioid sarcoma.

Immunohistochemistry

  • Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma.
  • Vimentin reactivity
  • Pankeratin AE1/AE3 and epithelial membrane antigen[1]
  • Negative S100

Reference

  1. Epithelioid sarcoma. Sarcomahelp (2016). http://sarcomahelp.org/epithelioid-sarcoma.html Accessed on February 8, 2016