Epithelioid sarcoma other diagnostic studies: Difference between revisions
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Other diagnostic studies for epithelioid sarcoma include genetic testing and immunohistochemistry. | Other diagnostic studies for epithelioid sarcoma include genetic testing and immunohistochemistry. | ||
==Genetic Testing== | ==Genetic Testing== | ||
*Loss of INI1 (also known as hSNF5 and SMARCB1) which is a member of SWI/SNF multi-subunit chromatin remodeling complex located on the long arm of chromosome 22 (22q11.2) has been a diagnostic modality of epithelioid sarcoma. | *Loss of INI1 (also known as hSNF5 and SMARCB1),which is a member of SWI/SNF multi-subunit chromatin remodeling complex located on the long arm of chromosome 22 (22q11.2), has been used as a diagnostic modality of epithelioid sarcoma. | ||
==Immunohistochemistry== | ==Immunohistochemistry== | ||
* Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma. | * Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma. | ||
* Vimentin reactivity | * Vimentin reactivity | ||
* Pankeratin AE1/AE3 and epithelial membrane antigen | * Pankeratin AE1/AE3 and epithelial membrane antigen<ref> Epithelioid sarcoma. Sarcomahelp (2016). http://sarcomahelp.org/epithelioid-sarcoma.html Accessed on February 8, 2016</ref> | ||
* Negative S100 | * Negative S100 | ||
==Reference== | ==Reference== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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Latest revision as of 22:20, 26 November 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Other diagnostic studies for epithelioid sarcoma include genetic testing and immunohistochemistry.
Genetic Testing
- Loss of INI1 (also known as hSNF5 and SMARCB1),which is a member of SWI/SNF multi-subunit chromatin remodeling complex located on the long arm of chromosome 22 (22q11.2), has been used as a diagnostic modality of epithelioid sarcoma.
Immunohistochemistry
- Immunohistochemical staining of INI1 is available and can be used for the diagnosis of epithelioid sarcoma.
- Vimentin reactivity
- Pankeratin AE1/AE3 and epithelial membrane antigen[1]
- Negative S100
Reference
- ↑ Epithelioid sarcoma. Sarcomahelp (2016). http://sarcomahelp.org/epithelioid-sarcoma.html Accessed on February 8, 2016