Hypergammaglobulinemia classification: Difference between revisions

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==Overview==
==Overview==


==Classification==
*Hypergammaglobulinemia may be classified into the following:
**Hyper Ig M associated hypergammaglobulinemias
**Hyper Ig D syndrome
**Hyper Ig E syndrome
*Hyper IgM associated hypergammaglobulinemias are further classified into the following five types:<ref>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016</ref><ref name=OMIM>Immunodeficiency with hyper-IgM, Type 1; HIGM1. http://www.omim.org/entry/308230. Accessed on February 24, 2016</ref>


{| style="border: 0px; font-size: 90%; margin: 3px; width:650px"
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! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type}}
! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Gene involved}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Mode of inheritance}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |
Type 1
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*Tumor Necrosis Factor Super Family member 5 (''TNFSF5'') gene encoding CD40L
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |
X-linked recessive
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|
Type 2
| style="padding: 5px 5px; background: #F5F5F5;" |
*Activation-Induced Cytidine Deaminase (''AICDA'') gene
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |
Autosomal recessive
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|
Type 3
| style="padding: 5px 5px; background: #F5F5F5;" |
*''CD40'' gene
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Autosomal recessive
|-
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Type 4
| style="padding: 5px 5px; background: #F5F5F5;" |
*Not yet known
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|-
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Type 5
| style="padding: 5px 5px; background: #F5F5F5;" |
*Gene encoding Uracil-DNA glycosylase
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |
Autosomal recessive
|}


==References==
==References==
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*[[Monoclonal gammopathy of undetermined significance]]
*[[Monoclonal gammopathy of undetermined significance]]
{{Immune disorders}}
{{Immune disorders}}
[[Category:Rheumatology]]
[[Category:Rheumatology]]
[[Category:Immunology]]
[[Category:Immunology]]
[[Category:Needs content]]
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}

Latest revision as of 18:57, 2 March 2016

Hypergammaglobulinemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hypergammaglobulinemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Classification

  • Hypergammaglobulinemia may be classified into the following:
    • Hyper Ig M associated hypergammaglobulinemias
    • Hyper Ig D syndrome
    • Hyper Ig E syndrome
  • Hyper IgM associated hypergammaglobulinemias are further classified into the following five types:[1][2]
Type Gene involved Mode of inheritance

Type 1

  • Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene encoding CD40L

X-linked recessive

Type 2

  • Activation-Induced Cytidine Deaminase (AICDA) gene

Autosomal recessive

Type 3

  • CD40 gene

Autosomal recessive

Type 4

  • Not yet known

Type 5

  • Gene encoding Uracil-DNA glycosylase

Autosomal recessive

References

  1. ↑ Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016
  2. ↑ Immunodeficiency with hyper-IgM, Type 1; HIGM1. http://www.omim.org/entry/308230. Accessed on February 24, 2016

Related Chapters

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