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==Classification==
==Classification==
*Hyper IgM associated hypergammaglobulinemias may be classified into the following five types:
*Hypergammaglobulinemia may be classified into the following:
**Hyper Ig M associated hypergammaglobulinemias
**Hyper Ig D syndrome
**Hyper Ig E syndrome
*Hyper IgM associated hypergammaglobulinemias are further classified into the following five types:<ref>Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016</ref><ref name=OMIM>Immunodeficiency with hyper-IgM, Type 1; HIGM1. http://www.omim.org/entry/308230. Accessed on February 24, 2016</ref>


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! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Type}}
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! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Gene involved}}
! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Gene involved}}
! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|Mode of inheritance}}
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Type 1
Type 1
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*Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene
*Tumor Necrosis Factor Super Family member 5 (''TNFSF5'') gene encoding CD40L
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X-linked recessive
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Type 2
Type 2
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*Activation-Induced Cytidine Deaminase (AICDA) gene
*Activation-Induced Cytidine Deaminase (''AICDA'') gene
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Autosomal recessive
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Type 3
Type 3
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*CD40
*''CD40'' gene
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Autosomal recessive
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*Not yet known
*Not yet known
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Type 5
Type 5
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*UNG gene
*Gene encoding Uracil-DNA glycosylase
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Autosomal recessive
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*[[Monoclonal gammopathy of undetermined significance]]
*[[Monoclonal gammopathy of undetermined significance]]
{{Immune disorders}}
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Latest revision as of 18:57, 2 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Classification

  • Hypergammaglobulinemia may be classified into the following:
    • Hyper Ig M associated hypergammaglobulinemias
    • Hyper Ig D syndrome
    • Hyper Ig E syndrome
  • Hyper IgM associated hypergammaglobulinemias are further classified into the following five types:[1][2]
Type Gene involved Mode of inheritance

Type 1

  • Tumor Necrosis Factor Super Family member 5 (TNFSF5) gene encoding CD40L

X-linked recessive

Type 2

  • Activation-Induced Cytidine Deaminase (AICDA) gene

Autosomal recessive

Type 3

  • CD40 gene

Autosomal recessive

Type 4

  • Not yet known

Type 5

  • Gene encoding Uracil-DNA glycosylase

Autosomal recessive

References

  1. ↑ Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016
  2. ↑ Immunodeficiency with hyper-IgM, Type 1; HIGM1. http://www.omim.org/entry/308230. Accessed on February 24, 2016

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