Klebsiella granulomatis: Difference between revisions
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==Overview== | ==Overview== | ||
''Klebsiella granulomatis'', originally classified as ''Calymmatobacterium granulomatis'', is a fastidious [[Gram-negative]] [[pleomorphic]] bacteria causing donovanosis, a [[gential ulcer disease]]. | |||
==Organism== | |||
*Aragão and Vianna classified the bacteria causing donovanosis as ''Calymmatobacterium granulomatis'' in 1913. However, DNA sequencing of 16S rRNA and ''phoE'' genes revealed similarity to ''Klebsiella''.<ref name="VelhoSouza2008">{{cite journal|last1=Velho|first1=Paulo Eduardo Neves Ferreira|last2=Souza|first2=Elemir Macedo de|last3=Belda Junior|first3=Walter|title=Donovanosis|journal=Brazilian Journal of Infectious Diseases|volume=12|issue=6|year=2008|issn=1413-8670|doi=10.1590/S1413-86702008000600015}}</ref> | |||
:*There is 99% homology between the etiologic agent of donovanosis and members of ''Klebsiella''.<ref name="pmid9350758">{{cite journal| author=Carter J, Hutton S, Sriprakash KS, Kemp DJ, Lum G, Savage J et al.| title=Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells. | journal=J Clin Microbiol | year= 1997 | volume= 35 | issue= 11 | pages= 2915-7 | pmid=9350758 | doi= | pmc=PMC230086 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9350758 }} </ref> | |||
:*A proposal has been put forth to reclassify the bacteria to ''Klebsiella granulomatis''. | |||
*''K. granulomatis'' morphology:<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048 }} </ref> | |||
:*[[Pleomorphic]] ranging from [[coccus]] to [[bacillus]] | |||
:*1-2 X 0.5-0.7 μm | |||
:*May or may not be capsulated | |||
:*Non-motile | |||
==Human Pathogen== | |||
*''K. granulomatis'' is an [[obligate]], intracellular human [[pathogen]]. | |||
*''K. granulomatis'' is typically transmitted through sexual contact but may also be transmitted through direct contact and fecal contamination.<ref name=" O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810 }} </ref> | |||
==Gallery== | ==Gallery== | ||
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[[Category:Sexually transmitted infections]] | [[Category:Sexually transmitted infections]] | ||
[[Category:Bacterial diseases]] | [[Category:Bacterial diseases]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
Latest revision as of 18:08, 18 September 2017
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Donovanosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Klebsiella granulomatis On the Web |
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American Roentgen Ray Society Images of Klebsiella granulomatis |
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Risk calculators and risk factors for Klebsiella granulomatis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.;
Overview
Klebsiella granulomatis, originally classified as Calymmatobacterium granulomatis, is a fastidious Gram-negative pleomorphic bacteria causing donovanosis, a gential ulcer disease.
Organism
- Aragão and Vianna classified the bacteria causing donovanosis as Calymmatobacterium granulomatis in 1913. However, DNA sequencing of 16S rRNA and phoE genes revealed similarity to Klebsiella.[1]
- There is 99% homology between the etiologic agent of donovanosis and members of Klebsiella.[2]
- A proposal has been put forth to reclassify the bacteria to Klebsiella granulomatis.
- K. granulomatis morphology:[3]
- Pleomorphic ranging from coccus to bacillus
- 1-2 X 0.5-0.7 μm
- May or may not be capsulated
- Non-motile
Human Pathogen
- K. granulomatis is an obligate, intracellular human pathogen.
- K. granulomatis is typically transmitted through sexual contact but may also be transmitted through direct contact and fecal contamination.[4]
Gallery
-
![This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5]](/images/b/ba/Granuloma_inguinale12.jpeg)
This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5]
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![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](/images/e/ef/Enterobacteria28.jpeg)
“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]
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![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](/images/d/da/Enterobacteria56.jpeg)
“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]
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![Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]](/images/f/f6/Enterobacteria27.jpeg)
Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]
![This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. From Public Health Image Library (PHIL). [5]](/index.php/File:Granuloma_inguinale12.jpeg)
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](/index.php/File:Enterobacteria28.jpeg)
![“Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. From Public Health Image Library (PHIL). [5]](/index.php/File:Enterobacteria56.jpeg)
![Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. From Public Health Image Library (PHIL). [5]](/index.php/File:Enterobacteria27.jpeg)
References
- ↑ Velho, Paulo Eduardo Neves Ferreira; Souza, Elemir Macedo de; Belda Junior, Walter (2008). "Donovanosis". Brazilian Journal of Infectious Diseases. 12 (6). doi:10.1590/S1413-86702008000600015. ISSN 1413-8670.
- ↑ Carter J, Hutton S, Sriprakash KS, Kemp DJ, Lum G, Savage J; et al. (1997). "Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells". J Clin Microbiol. 35 (11): 2915–7. PMC 230086. PMID 9350758.
- ↑ Richens J (1991). "The diagnosis and treatment of donovanosis (granuloma inguinale)". Genitourin Med. 67 (6): 441–52. PMC 1194766. PMID 1774048.
- ↑ O'Farrell N (2002). "Donovanosis". Sex Transm Infect. 78 (6): 452–7. PMC 1758360. PMID 12473810.
- ↑ 5.0 5.1 5.2 5.3 "Public Health Image Library (PHIL)".