Hypergammaglobulinemia history and symptoms: Difference between revisions
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==History== | ==History== | ||
*A positive family history of hypergammaglobulinemia may be present. | |||
*History of severe and/or recurrent bacterial respiratory and gastrointestinal infections as well as opportunistic infections may be present in patients with x-linked hyper-IgM. | |||
==Symptoms== | ==Symptoms== | ||
===Type 1 Hyper-IgM Immunodeficiency=== | ===Type 1 Hyper-IgM Immunodeficiency=== | ||
*Symptoms of type 1 hyper-IgM immunodeficiency are a result of | *The majority of patients with x-linked hyper-IgM are symptomatic by infancy.<ref name="pmid19597006">{{cite journal| author=Fried AJ, Bonilla FA| title=Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections. | journal=Clin Microbiol Rev | year= 2009 | volume= 22 | issue= 3 | pages= 396-414 | pmid=19597006 | doi=10.1128/CMR.00001-09 | pmc=PMC2708392 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19597006 }} </ref> | ||
*Symptoms of type 1 hyper-IgM immunodeficiency are a result of infection and may include the following: | |||
**Fever | |||
**Cough | **Cough | ||
**Tachypnea | **Tachypnea | ||
**Dyspnea | **Dyspnea | ||
**Diarrhea | **Diarrhea | ||
*Other symptoms may include: | |||
**Pruritis | |||
==References== | ==References== | ||
Latest revision as of 13:23, 2 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
History
- A positive family history of hypergammaglobulinemia may be present.
- History of severe and/or recurrent bacterial respiratory and gastrointestinal infections as well as opportunistic infections may be present in patients with x-linked hyper-IgM.
Symptoms
Type 1 Hyper-IgM Immunodeficiency
- The majority of patients with x-linked hyper-IgM are symptomatic by infancy.[1]
- Symptoms of type 1 hyper-IgM immunodeficiency are a result of infection and may include the following:
- Fever
- Cough
- Tachypnea
- Dyspnea
- Diarrhea
- Other symptoms may include:
- Pruritis
References
- ↑ Fried AJ, Bonilla FA (2009). "Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections". Clin Microbiol Rev. 22 (3): 396–414. doi:10.1128/CMR.00001-09. PMC 2708392. PMID 19597006.