Primary cutaneous follicle centre lymphoma pathophysiology: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
 
(10 intermediate revisions by 3 users not shown)
Line 3: Line 3:
{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
Primary cutaneous follicle center lymphoma is a tumor of neoplastic follicle centre cells, including centrocytes and variable numbers of centroblasts, with a follicular and diffuse growth pattern that generally presents on the head or trunk. This is the most common type of primary cutaneous B-cell lymphoma.<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref> Primary cutaneous follicle center lymphoma (PCFCL) may be associated with  [[borrelia burgdorferi]], [[hepatitis C]], and [[human herpesvirus 8]]. On gross pathology,solitary or grouped erythematous [[papules]], [[plaques]] and [[tumor]] lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle center lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
Primary cutaneous follicle centre lymphoma is a tumor of neoplastic follicle centre cells, including centrocytes and variable numbers of centroblasts, with a follicular and diffuse growth pattern that generally presents on the head or trunk.<ref name="cancer.gov"> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include ''C-REL''  and ''BCL-2'' genes. Primary cutaneous follicle centre lymphoma (PCFCL) may be associated with  [[borrelia burgdorferi]], [[hepatitis C]], and [[human herpesvirus 8]]. On gross pathology,solitary or grouped erythematous [[papules]], [[plaques]] and [[tumor]] lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle centre lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle centre lymphoma.
==Pathophysiology==
==Pathophysiology==
Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.<ref name=hindawi> Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/.  Accessed on March 02, 2016</ref>  
Primary cutaneous follicle centre lymphoma is a tumor of neoplastic follicle centre cells, including centrocytes and variable numbers of centroblasts, with a follicular and diffuse growth pattern that generally presents on the head or trunk.<ref name="cancer.gov" />Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include ''C-REL''  and ''BCL-2'' genes.<ref name="cancer.gov" /> Primary cutaneous follicle centre lymphoma (PCFCL) may be associated with  [[borrelia burgdorferi]], [[hepatitis C]], and [[human herpesvirus 8]]. On gross pathology,solitary or grouped erythematous [[papules]], [[plaques]] and [[tumor]] lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle centre lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle centre lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
 
Primary cutaneous follicle centre lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.<ref name="hindawi"> Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/.  Accessed on March 02, 2016</ref>  
==Genetics==
==Genetics==
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name=cancer.gov> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:<ref name="cancer.gov"> Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016</ref>
* Amplification of ''C-REL'' gene
* Amplification of ''C-REL'' gene
* ''BCL-2'' rearrangements
* ''BCL-2'' rearrangements


==Association==
==Association==
Primary cutaneous follicle center lymphoma (PCFCL) may be associated with:<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
Primary cutaneous follicle centre lymphoma (PCFCL) may be associated with:<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
* [[Borrelia burgdorferi]]
* [[Borrelia burgdorferi]]
* [[Hepatitis C]]  
* [[Hepatitis C]]  
* [[Human herpesvirus 8]]   
* [[Human herpesvirus 8]]   
==Gross Pathology==
==Gross Pathology==
On gross pathology, solitary or grouped erythematous [[papules]], [[plaques]] and [[tumor]] lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle center lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
On gross pathology, solitary or grouped erythematous [[papules]], [[plaques]] and [[tumor]] lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle centre lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
{|style="margin: 0 auto;"
| [[File:Primary cutaneous follicle centre lymphoma images.jpg|250px|thumb|upright|Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lympoma image 4.jpg|250px|thumb|upright|A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147.  Accessed on March 02, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lymphoma image 05.jpg|250px|thumb|upright|A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147.  Accessed on March 02, 2016</ref>]]
|}


==Microscopic Pathology==
==Microscopic Pathology==
On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle center lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle centre lymphoma.<ref name="pmid23786884">{{cite journal| author=Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I et al.| title=Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. | journal=Radiat Oncol | year= 2013 | volume= 8 | issue=  | pages= 147 | pmid=23786884 | doi=10.1186/1748-717X-8-147 | pmc=PMC3702489 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23786884  }} </ref>
* Histopathological appearance of primary cutaneous follicle centre lymphoma include:<ref name="biomedcentral">Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147.  Accessed on March 02, 2016</ref>
:* Epidemis
::* Superficially regular and preserved
:*Deep dermis
::* Abundant lymphocytic infiltrate with the formation of follicular germinal center and the surrounding ‘mantle zone’
::* The infiltrate was composed of atypical, medium-sized and focally large lymphatic cells
 


{|style="margin: 0 auto;"
| [[File:Primary cutaneous follicle centre lymphoma image 06.jpg|250px|thumb|upright|The epidermis is preserved, with diffuse and nodular infiltrates of lymphoid cells.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147.  Accessed on March 02, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lymphoma image 07.jpg|250px|thumb|upright|The epidermis is preserved, with diffuse and nodular infiltrates of lymphoid cells.<ref name=biomedcentral>Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147.  Accessed on March 02, 2016</ref>]]
| [[File:Primary cutaneous follicle centre lymphoma image 2.jpg|350px|thumb|upright|Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).<ref name=biomedcentral> Primary cutaneous follicle centre lymphoma. BioMed Central. https://biomarkerres.biomedcentral.com/articles/10.1186/2050-7771-2-7.  Accessed on March 01, 2016</ref>]]
|}


==References==
==References==
Line 38: Line 37:
[[Category:Disease]]
[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Gastroenterology]]
[[Category:Oncology]]
[[Category:Hepatology]]
[[Category:Hematology]]
[[Category:Hematology]]


{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Immunology]]
[[Category:Hematology]]
[[Category:Dermatology]]
[[Category:Surgery]]

Latest revision as of 23:02, 24 October 2019

Primary cutaneous follicle centre lymphoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Primary cutaneous follicle centre lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Primary cutaneous follicle centre lymphoma pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Primary cutaneous follicle centre lymphoma pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Primary cutaneous follicle centre lymphoma pathophysiology

CDC on Primary cutaneous follicle centre lymphoma pathophysiology

Primary cutaneous follicle centre lymphoma pathophysiology in the news

Blogs on Primary cutaneous follicle centre lymphoma pathophysiology

Directions to Hospitals Treating Splenic marginal zone lymphoma

Risk calculators and risk factors for Primary cutaneous follicle centre lymphoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Primary cutaneous follicle centre lymphoma is a tumor of neoplastic follicle centre cells, including centrocytes and variable numbers of centroblasts, with a follicular and diffuse growth pattern that generally presents on the head or trunk.[1]Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include C-REL and BCL-2 genes. Primary cutaneous follicle centre lymphoma (PCFCL) may be associated with borrelia burgdorferi, hepatitis C, and human herpesvirus 8. On gross pathology,solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle centre lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle centre lymphoma.

Pathophysiology

Primary cutaneous follicle centre lymphoma is a tumor of neoplastic follicle centre cells, including centrocytes and variable numbers of centroblasts, with a follicular and diffuse growth pattern that generally presents on the head or trunk.[1]Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include C-REL and BCL-2 genes.[1] Primary cutaneous follicle centre lymphoma (PCFCL) may be associated with borrelia burgdorferi, hepatitis C, and human herpesvirus 8. On gross pathology,solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle centre lymphoma. On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle centre lymphoma.[2]

Primary cutaneous follicle centre lymphoma (PCFCL) is characterized by a proliferation of follicle center cells (centrocytes and centroblasts) with a follicular, follicular and diffuse, or diffuse growth pattern.[3]

Genetics

Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:[1]

  • Amplification of C-REL gene
  • BCL-2 rearrangements

Association

Primary cutaneous follicle centre lymphoma (PCFCL) may be associated with:[2]

Gross Pathology

On gross pathology, solitary or grouped erythematous papules, plaques and tumor lesions, mostly non-ulcerated are characteristic findings of primary cutaneous follicle centre lymphoma.[2]

Microscopic Pathology

On microscopic histopathological analysis, centroblasts (large noncleaved cells), centrocytes (small and large cleaved cells), and reactive T cells are characteristic findings of primary cutaneous follicle centre lymphoma.[2]

  • Histopathological appearance of primary cutaneous follicle centre lymphoma include:[4]
  • Epidemis
  • Superficially regular and preserved
  • Deep dermis
  • Abundant lymphocytic infiltrate with the formation of follicular germinal center and the surrounding ‘mantle zone’
  • The infiltrate was composed of atypical, medium-sized and focally large lymphatic cells


References

  1. 1.0 1.1 1.2 1.3 Primary cutaneous follicle centre lymphoma. Surveillance, Epidemiology, and End Results Program. http://seer.cancer.gov/seertools/hemelymph/51f6cf5ae3e27c3994bd549b/. Accessed on March 02, 2016
  2. 2.0 2.1 2.2 2.3 Ceovic R, Jovanovic I, Kostovic K, Rados J, Dotlic S, Radman I; et al. (2013). "Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature". Radiat Oncol. 8: 147. doi:10.1186/1748-717X-8-147. PMC 3702489. PMID 23786884.
  3. Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma—An Unusual Presentation. Hindawi. http://www.hindawi.com/journals/crim/2010/296523/. Accessed on March 02, 2016
  4. Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016


Template:WikiDoc Sources