Donovanosis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
''Klebsiella granulomatis'' may be transmitted through sexual contact, direct contact, or fecal contamination. ''K. granulomatis'' may also [[Autoinoculation|autoinoculate]], resulting in multiple lesions. The pathogenesis of ''K. granulomatis'' is not well characterized. ''K. granulomatis'' replicates intracellularly within [[monocytes]] after being [[Phagocytosis|phagocytosed]]. Monocytes eventually rupture, recruiting additional monocytes and causing the formation of [[granulomas]]. On microscopic examination, [[pleomorphic]] Donovan bodies can be seen within the cytoplasm or [[phagosomes]] of monocytes. | |||
==Pathophysiology== | ==Pathophysiology== | ||
===Transmission=== | ===Transmission=== | ||
*''Klebsiella granulomatis'' may be transmitted through sexual contact. | *''Klebsiella granulomatis'' may be transmitted through sexual contact. | ||
*Although donovanosisis is typically considered a [[sexually transmitted disease]], studies indicate it may also develop through fecal contamination or | *Although donovanosisis is typically considered a [[sexually transmitted disease]], studies indicate it may also develop through fecal [[contamination]] or direct contact. | ||
*''K. granulomatis'' may also autoinoculate, resulting in multiple lesions that appear to be mirror images of each other.<ref name=" O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810 }} </ref> | *''K. granulomatis'' may also [[Autoinoculation|autoinoculate]], resulting in multiple lesions that appear to be mirror images of each other.<ref name="O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810 }} </ref> | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
*The pathogenesis of ''K. granulomatis'' is not well characterized. | |||
*''K. granulomatis'' is [[Phagocytosis|phagocytosed]] by [[macrophages]]. | |||
*''K. granulomatis'' is able to avoid destruction and replicates intracellularly within these [[monocytes]]. | |||
== | *Monocytes eventually rupture, recruiting additional monocytes and causing the formation of [[granulomas]].<ref name=" O'Farrell"></ref><ref name="Richens"></ref> | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
*Donovan bodies (''K. granulomatis'') are seen within phagosomes or in the cytoplasm of monocytes or histocytes. | *Donovan bodies (''K. granulomatis'') are seen within [[Phagosome|phagosomes]] or in the cytoplasm of [[Monocyte|monocytes]] or [[Histiocyte|histocytes]]. | ||
*Morphology of Donovan bodies: | *Morphology of Donovan bodies: | ||
:*Pleomorphic ranging from coccus to bacillus | :*[[Pleomorphic]] ranging from [[coccus]] to [[bacillus]] | ||
:*1-2 X 0.5-0.7 μm | :*1-2 X 0.5-0.7 μm | ||
:*May or may not be capsulated | :*May or may not be capsulated | ||
:*Non-motile | :*Non-motile | ||
*[[Epidermis]] of lesion borders show a degree of [[hyperplasia]]. | *[[Epidermis]] of lesion borders show a degree of [[hyperplasia]]. | ||
*A dense infiltrate of plasma cells is seen in the [[dermis]].<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048 }} </ref> | *A dense infiltrate of [[Plasma cell|plasma cells]] is seen in the [[dermis]].<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048 }} </ref> | ||
==References== | ==References== | ||
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[[Category:Sexually transmitted infections]] | [[Category:Sexually transmitted infections]] | ||
[[Category:Bacterial diseases]] | [[Category:Bacterial diseases]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Latest revision as of 17:37, 18 September 2017
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Donovanosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Donovanosis pathophysiology On the Web |
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American Roentgen Ray Society Images of Donovanosis pathophysiology |
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Risk calculators and risk factors for Donovanosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]; Nate Michalak, B.A.
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Overview
Klebsiella granulomatis may be transmitted through sexual contact, direct contact, or fecal contamination. K. granulomatis may also autoinoculate, resulting in multiple lesions. The pathogenesis of K. granulomatis is not well characterized. K. granulomatis replicates intracellularly within monocytes after being phagocytosed. Monocytes eventually rupture, recruiting additional monocytes and causing the formation of granulomas. On microscopic examination, pleomorphic Donovan bodies can be seen within the cytoplasm or phagosomes of monocytes.
Pathophysiology
Transmission
- Klebsiella granulomatis may be transmitted through sexual contact.
- Although donovanosisis is typically considered a sexually transmitted disease, studies indicate it may also develop through fecal contamination or direct contact.
- K. granulomatis may also autoinoculate, resulting in multiple lesions that appear to be mirror images of each other.[1]
Pathogenesis
- The pathogenesis of K. granulomatis is not well characterized.
- K. granulomatis is phagocytosed by macrophages.
- K. granulomatis is able to avoid destruction and replicates intracellularly within these monocytes.
- Monocytes eventually rupture, recruiting additional monocytes and causing the formation of granulomas.[1][2]
Microscopic Pathology
- Donovan bodies (K. granulomatis) are seen within phagosomes or in the cytoplasm of monocytes or histocytes.
- Morphology of Donovan bodies:
- Pleomorphic ranging from coccus to bacillus
- 1-2 X 0.5-0.7 μm
- May or may not be capsulated
- Non-motile
- Epidermis of lesion borders show a degree of hyperplasia.
- A dense infiltrate of plasma cells is seen in the dermis.[2]