Mast cell tumor physical examination: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Mast cell tumor}} | {{Mast cell tumor}} | ||
{{CMG}}; {{AE}} {{JH}} | {{CMG}};{{AE}}{{JH}}, {{PSK}} | ||
==Overview== | ==Overview== | ||
Physical examination for mast cell tumor include inspection for a large assortment of types of skin lesions, testing for [[dermatographism]] (Darier's sign), and palpating for [[hepatosplenomegaly]] and [[lymphadenopathy]]. | |||
==Physical Examination== | ==Physical Examination== | ||
===Vital signs=== | ===Vital signs=== | ||
| Line 9: | Line 11: | ||
*[[Tachycardia]] | *[[Tachycardia]] | ||
===Skin=== | ===Skin=== | ||
*'''Urticaria pigmentosa''': | *'''Urticaria pigmentosa''':<ref name="pmid14018418">{{cite journal |vauthors=CAPLAN RM |title=The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases |journal=Arch Dermatol |volume=87 |issue= |pages=146–57 |date=February 1963 |pmid=14018418 |doi= |url=}}</ref> | ||
:*Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref> | :*Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref> | ||
:*Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas. | :*Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas. | ||
:*The trunk and thigh are more commonly involved with sparing of face, palms and soles. | :*The trunk and thigh are more commonly involved with sparing of face, palms and soles. | ||
*'''Darier’s sign''': | *'''Darier’s sign''':<ref name="pmid10909039">{{cite journal |vauthors=Soter NA |title=Mastocytosis and the skin |journal=Hematol. Oncol. Clin. North Am. |volume=14 |issue=3 |pages=537–55, vi |date=June 2000 |pmid=10909039 |doi= |url=}}</ref> | ||
:*Lesions urticate in response to physical irritation. | :*Lesions urticate in response to physical irritation. | ||
:*Localized erythema and urticaria erupts within short period of time (minutes) in response to physical irritation. | |||
*'''Diffuse Cutaneous Mastocytosis''' | |||
:*Diffuse infiltrative yellow-orange xanthogranuloma-like subcutaneous nodules, or as a widespread urticarial eruption with bullae and redness.<ref name="FerranteScavone2015">{{cite journal|last1=Ferrante|first1=Giuliana|last2=Scavone|first2=Valeria|last3=Muscia|first3=Maria|last4=Adrignola|first4=Emilia|last5=Corsello|first5=Giovanni|last6=Passalacqua|first6=Giovanni|last7=La Grutta|first7=Stefania|title=The care pathway for children with urticaria, angioedema, mastocytosis|journal=World Allergy Organization Journal|volume=8|issue=1|year=2015|pages=5|issn=1939-4551|doi=10.1186/s40413-014-0052-x}}</ref> | |||
* '''Telangiectasia macularis eruptiva perstans'''<ref name="pmid25439382">{{cite journal |vauthors=Williams KW, Metcalfe DD, Prussin C, Carter MC, Komarow HD |title=Telangiectasia macularis eruptiva perstans or highly vascularized urticaria pigmentosa? |journal=J Allergy Clin Immunol Pract |volume=2 |issue=6 |pages=813–5 |date=2014 |pmid=25439382 |pmc=4254445 |doi=10.1016/j.jaip.2014.07.002 |url=}}</ref> | |||
** It is a rare form of mastocytosis, and presents as brownish macules and telangiectasia. | |||
** Not associated with pruritus and blistering. | |||
===Abdomen=== | |||
*[[Hepatomegaly]] | |||
*[[Splenomegaly]] | |||
<gallery> | <gallery> | ||
Image:Mastocytoma_01.jpeg|Mastocytoma. <BR><SMALL><SMALL>Adapted from ''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5Dermatology Atlas]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url =http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=278}} | Image:Mastocytoma_01.jpeg|Mastocytoma. <BR><SMALL><SMALL>Adapted from ''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5Dermatology Atlas]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url =http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=278}} | ||
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== References == | == References == | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Hematology]] | |||
[[Category:Immunology]] | |||
Latest revision as of 02:06, 25 March 2019
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Mast cell tumor physical examination On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2], Suveenkrishna Pothuru, M.B,B.S. [3]
Overview
Physical examination for mast cell tumor include inspection for a large assortment of types of skin lesions, testing for dermatographism (Darier's sign), and palpating for hepatosplenomegaly and lymphadenopathy.
Physical Examination
Vital signs
Skin
- Urticaria pigmentosa:[1]
- Fixed, reddish brown lesions appears as maculo-papules, plaques, nodules, or blisters.[2]
- Urticaria Pigmentosa (UP) lesions tend to be larger, better delineated, and more hyperpigmented in children, as compared to adults, who tend to have numerous small lesions that coalesce to form mottled areas.
- The trunk and thigh are more commonly involved with sparing of face, palms and soles.
- Darier’s sign:[3]
- Lesions urticate in response to physical irritation.
- Localized erythema and urticaria erupts within short period of time (minutes) in response to physical irritation.
- Diffuse Cutaneous Mastocytosis
- Diffuse infiltrative yellow-orange xanthogranuloma-like subcutaneous nodules, or as a widespread urticarial eruption with bullae and redness.[2]
- Telangiectasia macularis eruptiva perstans[4]
- It is a rare form of mastocytosis, and presents as brownish macules and telangiectasia.
- Not associated with pruritus and blistering.
Abdomen
-
Mastocytoma.
Adapted from Atlas<ref name="www.atlasdermatologico.com.br">"Dermatology Atlas". -
Mastocytoma.
Adapted from Atlas<ref name="www.atlasdermatologico.com.br">"Dermatology Atlas". -
Mastocytoma.
Adapted from Atlas<ref name="www.atlasdermatologico.com.br">"Dermatology Atlas". -
Mastocytoma.
Adapted from Atlas<ref name="www.atlasdermatologico.com.br">"Dermatology Atlas".
References
- ↑ CAPLAN RM (February 1963). "The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases". Arch Dermatol. 87: 146–57. PMID 14018418.
- ↑ 2.0 2.1 Ferrante, Giuliana; Scavone, Valeria; Muscia, Maria; Adrignola, Emilia; Corsello, Giovanni; Passalacqua, Giovanni; La Grutta, Stefania (2015). "The care pathway for children with urticaria, angioedema, mastocytosis". World Allergy Organization Journal. 8 (1): 5. doi:10.1186/s40413-014-0052-x. ISSN 1939-4551.
- ↑ Soter NA (June 2000). "Mastocytosis and the skin". Hematol. Oncol. Clin. North Am. 14 (3): 537–55, vi. PMID 10909039.
- ↑ Williams KW, Metcalfe DD, Prussin C, Carter MC, Komarow HD (2014). "Telangiectasia macularis eruptiva perstans or highly vascularized urticaria pigmentosa?". J Allergy Clin Immunol Pract. 2 (6): 813–5. doi:10.1016/j.jaip.2014.07.002. PMC 4254445. PMID 25439382.