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{{SI}}
{{Gonadoblastoma}}
{{CMG}} {{AE}} Your Name
{{CMG}}; {{AE}} {{Sahar}}


{{SK}} Synonym 1; Synonym 2; Synonym 3
{{SK}} [[Gonadoblastomas]]; [[Gonadoblastomata]]
==Overview==
 
==Historical Perspective==
 
*Gonadoblastoma was first discovered by Scully, in 1953.
 
==Pathophysiology==
==[[Gonadoblastoma overview|Overview]]==
*A gonadoblastoma is a complex [[neoplasm]] composed of a mixture of [[gonad]]al elements, such as large primordial [[germ cell]]s, immature [[Sertoli cell]]s or [[granulosa cell]]s of the [[sex cord]], and gonadal [[stromal cell]]s.
 
*Abnormal chromosomal [[karyotype]], gonadal [[dysgenesis]], and the presence of a [[Y chromosome]] has been associated with the development of gonadoblastoma.
==[[Gonadoblastoma historical perspective|Historical Perspective]]==
==Causes==
 
* Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy.
==[[Gonadoblastoma classification|Classification]]==
==Differentiating Gonadoblastoma from other Diseases==
 
*Gonadoblastoma must be differentiated from other diseases that cause ovarian tumors, such as:
==[[Gonadoblastoma pathophysiology|Pathophysiology]]==
:*Germinoma
 
:*Cystadenoma
==[[Gonadoblastoma causes|Causes]]==
:*Cystadenocarcinoma
 
:*Endometrioid tumor
==[[Gonadoblastoma differential diagnosis|Differentiating Gonadoblastoma from other Diseases]]==
:*Brenner tumor
 
:*Leydig cell tumor
==[[Gonadoblastoma epidemiology and demographics|Epidemiology and Demographics]]==
:*Granulosa cell tumor
 
:*17-Hydroxylase Deficiency Syndrome
==[[Gonadoblastoma risk factors|Risk Factors]]==
:*5-Alpha-Reductase Deficiency
 
:*Amenorrhea
==[[Gonadoblastoma screening|Screening]]==
:*Congenital Adrenal Hyperplasia
 
:*Genital Anomalies
==[[Gonadoblastoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
:*Hypospadias
 
:*Pediatric Seminoma
==Diagnosis==
:*Turner Syndrome
[[Gonadoblastoma diagnostic study of choice|Diagnostic study of choice]] | [[Gonadoblastoma history and symptoms|History and Symptoms]] | [[Gonadoblastoma physical examination|Physical Examination]] | [[Gonadoblastoma laboratory findings|Laboratory Findings]] | [[Gonadoblastoma electrocardiogram|Electrocardiogram]] | [[Gonadoblastoma x ray|X-Ray Findings]] | [[Gonadoblastoma echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Gonadoblastoma CT scan|CT-Scan Findings]] | [[Gonadoblastoma MRI|MRI Findings]] | [[Gonadoblastoma other imaging findings|Other Imaging Findings]] | [[Gonadoblastoma other diagnostic studies|Other Diagnostic Studies]]
:*Meigs syndrome
 
=== Laboratory Findings ===
==Treatment==
*A chromosome analysis is diagnostic of Gonadoblastoma.
[[Gonadoblastoma medical therapy|Medical Therapy]] | [[Gonadoblastoma surgery|Surgery]] | [[Gonadoblastoma primary prevention|Primary Prevention]] | [[Gonadoblastoma secondary prevention|Secondary Prevention]] | [[Gonadoblastoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Gonadoblastoma future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Gonadoblastoma case study one|Case #1]]
 
 
[[Category:Medicine]]


===Imaging Findings===
*There are no [imaging study] findings associated with [disease name].
*[Imaging study 1] is the imaging modality of choice for [disease name].
*On [imaging study 1], [disease name] is characterized by [finding 1], [finding 2], and [finding 3].
*[Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].
=== Other Diagnostic Studies ===
*[Disease name] may also be diagnosed using [diagnostic study name].
*Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
== Treatment ==
=== Medical Therapy ===
*There is no treatment for [disease name]; the mainstay of therapy is supportive care.
*The mainstay of therapy for [disease name] is [medical therapy 1] and [medical therapy 2].
*[Medical therapy 1] acts by [mechanism of action1].
*Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
=== Surgery ===
*Surgery is the mainstay of therapy for gonadoblastoma.
*Surgical exploration via laparotomy and bilateral salpingo-oophorectomy (BSO) is the most common approach to the treatment of gonadoblastoma.
=== Prevention ===
*There are no primary preventive measures available for [disease name].
*Effective measures for the primary prevention of [disease name] include [measure1], [measure2], and [measure3].
*Once diagnosed and successfully treated, patients with [disease name] are followedup every [duration]. Followup testing includes [test 1], [test 2], and [test 3].
==References==
{{Reflist|2}}
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Gynecology]]
[[Category:Up-To-Date]]

Latest revision as of 06:33, 28 July 2020

Gonadoblastoma Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gonadoblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Synonyms and keywords: Gonadoblastomas; Gonadoblastomata


Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gonadoblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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